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A new approach to fight the aging process: rejuvenating the nuclear membrane.

A new discovery about the effects of aging in our cells could allow doctors to cure or prevent diabetes, fatty liver disease and other metabolic diseases — and possibly even turn back the clock on aging itself.

The new finding from the University of Virginia School of Medicine suggests that fatty liver disease and other unwanted effects of aging may be the result of our cells’ nuclei — the compartment containing our DNA — getting wrinkly. Those wrinkles appear to prevent our genes from functioning properly, the UVA researchers found.

There’s no wrinkle cream for nuclear membranes, but there is a tantalizing possibility: We might use viruses to smooth the membranes’ surfaces — and restore the cells to functioning as they did in the glow of youth.

Continue reading “Study proposes a new way to reverse the aging process” | >

What did they find out?

NASA’s Curiosity rover has uncovered the best evidence yet that life may have once existed on Mars.

In two separate studies on data collected by the Mars rover over the last few years, scientists identified an abundant source of organic matter in an ancient lakebed, and traced some of the planet’s atmospheric methane to its roots.

Continue reading “Breakthrough in search for Martian life as Curiosity finds organic matter and seasonal methane” | >

Hidden in the bones of ancient humans lies evidence of diseases that continue to distress people today. Recently, the examination of two 3,800-year old skeletons revealed the presence of a Yersinia pestis strain, famously the bacterium that causes plague. This strain is now the oldest of its kind sequenced to date, and suggests that the devastation that is the bubonic plague has a Bronze Age origin.

The discovery, published Friday in Nature Communications, pushes back the proposed age of the bubonic plague by 1,000 years. It also adds to the understanding of a disease that is still reported between one and seven times per year in the United States, despite its more ancient reputation: In the U.S. 80 percent of plague cases have been in the bubonic form. Although it’s been present throughout much of recorded history — it was the drive behind some of humanity’s deadliest pandemics including the Justinian Plague and the Black Death — the origin and age of the disease have remained largely a mystery.

“Contrary to previous studies suggesting that Y. pestis was unable to cause disease during that time, we provide evidence that bubonic plague has been affecting humans for at least the last 4,000 years,” study co-author Maria Spyrou tells Inverse.

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A breakthrough stem cell treatment that promises the first effective cure for heart disease will be offered to British patients this year, The Sunday Telegraph can reveal.

Hundreds of thousands stand to benefit after regulators approved a major trial of the regenerative drug capable of shrinking fatal scar tissue which follows a heart attack.

The “off-the-shelf” therapy, which can be harvested for thousands of recipients from one healthy donor, will begin being administered to patients at London’s Royal Brompton Hospital in November.

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IBM and the Department of Energy’s Oak Ridge National Laboratory have revealed the world’s “most powerful and smartest scientific supercomputer.” Known as Summit, IBM says that its new computer will be capable of processing 200,000 quadrillion calculations per second. To put that into perspective, if every person on Earth did a single calculation per second, it would take 305 days to do what Summit does in a single second. Assuming those numbers are accurate, that would make Summit the world’s fastest supercomputer. It would also mark the first time since 2012 that a U.S. computer held that title.

Summit has been in the works for several years now and features some truly impressive specs. According to Tech Crunch, the computer will feature 4,608 compute servers, 22 IBM Power9 chips and six Nvidia Tesla V100 GPUs each. In addition, the machine will feature more than 10 petabytes of memory. As the Nvidia GPUs attest, this machine will be primarily used for the development of artificial intelligence and machine learning. In addition to the work on A.I., Summit will also be used for research into energy and other scientific endeavors at Oak Ridge.

IBM was the Department of Energy’s general contractor for the Summit project, but it also had the help of several other partners within the tech industry. The GPUs were provided by Nvidia, which remains one of the leaders in cutting-edge GPU development. Mellanox and Redhat were also brought on to work on the development of Summit.

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The point of the experiment was to show how easy it is to bias any artificial intelligence if you train it on biased data. The team wisely didn’t speculate about whether exposure to graphic content changes the way a human thinks. They’ve done other experiments in the same vein, too, using AI to write horror stories, create terrifying images, judge moral decisions, and even induce empathy. This kind of research is important. We should be asking the same questions of artificial intelligence as we do of any other technology because it is far too easy for unintended consequences to hurt the people the system wasn’t designed to see. Naturally, this is the basis of sci-fi: imagining possible futures and showing what could lead us there. Issac Asimov gave wrote the “Three Laws of Robotics” because he wanted to imagine what might happen if they were contravened.

Even though artificial intelligence isn’t a new field, we’re a long, long way from producing something that, as Gideon Lewis-Kraus wrote in The New York Times Magazine, can “demonstrate a facility with the implicit, the interpretive.” But it still hasn’t undergone the kind of reckoning that causes a discipline to grow up. Physics, you recall, gave us the atom bomb, and every person who becomes a physicist knows they might be called on to help create something that could fundamentally alter the world. Computer scientists are beginning to realize this, too. At Google this year, 5,000 employees protested and a host of employees resigned from the company because of its involvement with Project Maven, a Pentagon initiative that uses machine learning to improve the accuracy of drone strikes.

Norman is just a thought experiment, but the questions it raises about machine learning algorithms making judgments and decisions based on biased data are urgent and necessary. Those systems, for example, are already used in credit underwriting, deciding whether or not loans are worth guaranteeing. What if an algorithm decides you shouldn’t buy a house or a car? To whom do you appeal? What if you’re not white and a piece of software predicts you’ll commit a crime because of that? There are many, many open questions. Norman’s role is to help us figure out their answers.

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