An excellent and inspiring writeup of the story of Dyno Therapeutics, one of the most exciting startups in the gene therapy world.
How AI can accelerate gene therapy.
An international scientific team including more than 40 authors from seven different countries, led by a researcher at the University of Malaga Juan Pascual Anaya, has managed to sequence the first genome of the myxini, also known as hagfish, the only large group of vertebrates for which there has been no reference genome of any of its species yet.
This finding, published in the journal Nature Ecology & Evolution, has allowed for deciphering the evolutionary history of genome duplications that occurred in the ancestors of vertebrates, a group that includes humans.
“This study has important implications in the evolutionary and molecular field, as it helps us understand the changes in the genome that accompanied the origin of vertebrates and their most unique structures, such as the complex brain, the jaw and the limbs,” explains the scientist of the Department of Animal Biology of the UMA Pascual Anaya, who has coordinated the research.
Try Cell to Singularity, free to play: https://l.linklyhq.com/l/1uNoFUplifting is the process of altering an animal — or even an alien — to be smarter or abl…
(BRLS), formerly known as Life Extension Foundation, Inc., is one of the world’s leading providers of financial support for otherwise unfunded research in the areas of cryobiology, interventive gerontology and cryonics. During the last decade alone, BRLS awarded more than $100 million in grants to highly-specialized cryogenic research organizations.
BRLS is exempt from taxation under Internal Revenue Service code Section 501©(4)1, and is operated exclusively to promote social welfare through scientific research and education. BRLS was founded in 1977, and since then, we have awarded hundreds of grants to scientists throughout the United States who are personally committed to our mission. These dedicated professionals take extraordinary steps to make their research as cost-effective as possible. We are careful to commit our research dollars to projects that are difficult or impossible to fund through government and institutional grants or other sources.
Nonprofit organization, whose goal is the extension of the healthy human lifespan
Biomedical Research and Longevity Society, Inc. (BRLS), formerly known as Life Extension Foundation, Inc., is one of the world’s leading providers of financial support for otherwise unfunded research in the areas of cryobiology, interventive gerontology and cryonics. During the last decade alone, BRLS awarded more than $100 million in grants to highly-specialized cryogenic research organizations.
Visit website: https://www.brlsociety.org/.
Astronomers discovered a mysterious gamma-ray feature outside our galaxy by analyzing 13 years of data from NASA’s Fermi Gamma-ray Space Telescope.
“It is a completely serendipitous discovery,” said Alexander Kashlinsky, a cosmologist at the University of Maryland and NASA’s Goddard Space Flight Center in Greenbelt, who presented the research at the 243rd meeting of the American Astronomical Society in New Orleans. “We found a much stronger signal in a different part of the sky than the one we were looking for.”
The gamma-ray signal is unexpected and intriguingly similar to another unexplained feature produced by some of the most energetic cosmic particles ever detected. A paper describing the findings is published in The Astrophysical Journal Letters.
The two-step process also produces hydrogen gas as a by-product, which could also be used as a zero-emission fuel.
“We are looking at active sites and how these sites are bonding with the reaction intermediates,” said Ping Liu of Brookhaven’s Chemistry Division. “By determining the barriers, or transition states, from one step to another, we learn exactly how the catalyst is functioning during the reaction.”
The researchers found that the iron-cobalt alloy works sequentially in the second stage and gets pushed to the side as the nanofiber grows. Using this information, the team could leach the catalysts using acid and reuse them again. If the entire process could be fueled by renewable energy, the process would be a carbon-negative approach to CO2 mitigation.
Continue reading “Researchers trap CO2 from air into nanofibers to prevent its release” »
With better food preservation and factories that are more precise along with more upgrades to the global supply line we could even eliminate poverty with the food that is wasted.
It is estimated that 1.3 billion metric tons of food are lost or wasted annually, translating to a financial loss of $1 trillion (USD) per year. And without significant changes, this problem is expected to grow to 2.1 billion metric tons and $1.5 trillion by 2030.
Staggering as these numbers might be, they do not take into account the hidden costs of food production, including labor, storage and salvage or the costs related to customer dissatisfaction, lost opportunities, and inventory/stocking level imprecision.
Continue reading “Food Waste Costs the World’s Economy $1T Each Year” »
In a preclinical study, researchers led by City of Hope have discovered that a type of immune cell in the human body, known to be important for allergy and other immune responses, can also attack cancer. The cells, called human type 2 innate lymphoid cells (ILC2s), can be expanded outside of the body and applied in larger numbers to overpower a tumor’s defenses and eliminate malignant cells in mouse models with cancer.
The findings are published in Cell in an article titled, “Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death.”
“The City of Hope team has identified human ILC2 cells as a new member of the cell family capable of directly killing all types of cancers, including blood cancers and solid tumors,” said Jianhua Yu, PhD, a professor in the department of hematology and hematopoietic cell transplantation at City of Hope and the study’s senior author. “In the future, these cells could be manufactured, preserved by freezing, and then administered to patients. Unlike T cell-based therapies, such as CAR T cells, which necessitate using the patient’s own cells due to their specific characteristics, ILC2s might be sourced from healthy donors, presenting a distinct potential therapeutic approach as an allogeneic and ‘off-the-shelf’ product.”
Prototypes, slideware and vaporware is easy. LG showed a cool prototype self driving concept car at CES 2024. There was also new AI marketing buzzwords and AI promises.
The concept car has swiveling seats so that passengers can look at any direction. There were also great LG screens to immerse passengers with video.
Real AI is emerging this year but there will also be a lot of AI Hype.
