Lifeboat Foundation

Nice; using gene regulatory protein from yeast as a method for reducing the work required for making cell-specific perturbations.

The human brain, the most complex object in the universe, has 86 billion neurons with trillions of yet-unmapped connections. Understanding how it generates behavior is a problem that has beguiled humankind for millennia, and is critical for developing effective therapies for the psychiatric disorders that incur heavy costs on individuals and on society. The roundworm C elegans, measuring a mere 1 millimeter, is a powerful model system for understanding how nervous systems produce behaviors. Unlike the human brain, it has only 302 neurons, and has completely mapped neural wiring of 6,000 connections, making it the closest thing to a computer circuit board in biology. Despite its relative simplicity, the roundworm exhibits behaviors ranging from simple reflexes to the more complex, such as searching for food when hungry, learning to avoid food that previously made it ill, and social behavior.

Understanding how this dramatically simpler nervous system works will give insights into how our vastly more complex brains function and is the subject of a paper published on December 26, 2016, in Nature Methods.

Not sure that I would claim 2016 as the year that AI exploded; I believe a better term for 2016 is the year that AI reinvented itself. I still see us in an evolution trend in 2017 as we still need to see more AI technology embedded in our back office platforms and apps than where we are today to claim we’re in a real AI explosion. Once we start seeing more IT organizations and CxOs embracing it in lowering their operational costs then we can claim we’re in an explosion.

Artificial intelligence isn’t a new concept. It is something that companies and businesses have been trying to implement (and something that society has feared) for decades. However, with all the recent advancements to democratize artificial intelligence and use it for good, almost every company started to turn to this technology and technique in 2016.

The year started with Facebook’s CEO Mark Zuckerberg announcing his plan to build an artificially intelligent assistant to do everything from adjusting the temperature in his house to checking up on his baby girl. He worked throughout the year to bring his plan to life, with an update in August that stated he was almost ready to show off his AI to the world.

Continue reading “2016: The year artificial intelligence exploded” »

Since their development in 1960, lasers have become an indispensable tool supporting our modern society, finding use in fields such as medicine, information, and industry. Thanks to their compact size and energy efficiency, semiconductor lasers are now one of the most important classes of laser, making possible a diverse range of applications. However, the threshold current of a typical semiconductor laser—the minimum electrical current required to induce lasing—increases with temperature. This is one of a number of disadvantages that can be overcome by using quantum dot lasers. Professor Yasuhiko Arakawa of the Institute of Industrial Science at the University of Tokyo has been researching quantum dot lasers for about 35 years, from their conception to commercialization.

An electron trapped in a microscopic box

Sunlight is composed of light of various colors. The property that determines the color of light is its wavelength, or in other words, the distance between two successive wave peaks or troughs. The location of the peaks and troughs in the waveform is known as its phase. As a laser emits light waves in a uniform phase at the same wavelength, the light can be transmitted as a beam over long distances at high intensity.

Continue reading “The Science and Engineering of Quantum Dot Lasers” »

What’s next? Nanocavities in a diamond for small devices.

Researchers have developed a new type of light-enhancing optical cavity that is only 200 nanometers tall and 100 nanometers across. Their new nanoscale system represents a step toward brighter single-photon sources, which could help propel quantum-based encryption techniques under development.

Quantum encryption techniques, which are seen as likely to be central to future data encryption methods, use individual photons as an extremely secure way to encode data. A limitation of these techniques has been the ability to emit photons at high rates. “One of the most important figures of merit for single-photon sources is brightness — or collected photons per second — because the brighter it is, the more data you can transmit securely with quantum encryption,” said Yousif Kelaita of Stanford University.

Continue reading “Ultra-Small Nanocavity Advances Technology for Quantum-Based Data Encryption” »

The body electrician.

Caloric restriction can help tumour supression.

Tumor suppressors stop healthy cells from becoming cancerous. Researchers from Charité — Universitätsmedizin Berlin, the Medical University of Graz and the German Institute of Human Nutrition in Potsdam-Rehbruecke have found that p53, one of the most important tumor suppressors, accumulates in liver after food withdrawal. They also show that p53 in liver plays a crucial role in the body’s metabolic adaptation to starvation. These findings may provide the foundation for the development of new treatment options for patients with metabolic or oncologic disorders. Results of this study have been published in The FASEB Journal.

Previously described as the ‘guardian of the genome’ and voted ‘Molecule of the Year’ in 1993, p53 is one of the most important proteins regulating cell growth and a major focus for oncology research. It is a protein that has the ability to interrupt the cell cycle and block the division of diseased cells. In order to better understand its physiological regulation, the researchers around Prof. Dr. Michael Schupp from Charité’s Institute of Pharmacology studied the regulation and function of p53 in normal, healthy cells. After withholding food from mice for several hours, the researchers were able to show that p53 protein accumulates in the liver. In order to determine which type of liver cells cause this accumulation, the researchers repeated the experiment using cultured hepatocytes. They found that the starvation-induced accumulation of p53 was indeed detectable in hepatocytes, irrespective of whether these cells were of mouse or human origin.

Continue reading “Food withdrawal results in stabilization of important tumor suppressor” »

Scientists are hailing a pioneering stem cell technique that promises “off-the-shelf” treatment for people with damaged muscles without the existing risks.

Researchers have for the first time successfully implanted “synthetic” cardiac stem cells which successfully repaired muscle tissue that had been weakened by a heart attack.

Traditional stem cell therapy comes with a risk of cancer because scientists are unable to stop the cells replicating and forming tumours.

Continue reading “Synthetic stem cells promise muscle regeneration without cancer risk” »

This thing was not imagination,” he says, jabbing his index finger into the tablecloth. By Cuarón’s estimation, anyone surprised at the accuracy of his movie’s predictions was either uninformed or willfully ignorant about the way the world already was by 2006.’

Revisiting the overlooked 2006 masterpiece with director Alfonso Cuarón.

A machine learning algorithm helped decode the squeaks Egyptian fruit bats make in their roost, revealing that they “speak” to one another as individuals.