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It is often not the lack of a cure, but the lack of will. Many great strides have been made with diabetes, when people stopped trying to develop medicines, and instead focused on how to enable the body to produce insulin.


Restoration of insulin independence and normoglycemia has been the overarching goal in diabetes research and therapy. While whole-organ and islet transplantation have become gold-standard procedures in achieving glucose control in diabetic patients, the profound lack of suitable donor tissues severely hampers the broad application of these therapies. Here, we describe current efforts aimed at generating a sustainable source of functional human stem cell-derived insulin-producing islet cells for cell transplantation and present state-of-the-art efforts to protect such cells via immune modulation and encapsulation strategies.

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My colleague Conor Sen recently made a bold prediction: Government will be the driver of the U.S. economy in coming decades. The era of Silicon Valley will end, supplanted by the imperatives of fighting climate change and competing with China.

This would be a momentous change. The biggest tech companies — Amazon.com, Apple Inc., Facebook Inc., Google (Alphabet Inc.) and (a bit surprisingly) Microsoft Corp. — have increasingly dominated both the headlines and the U.S. stock market:

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Japan, March 12, 2019—The Japan Aerospace Exploration Agency (JAXA) and Toyota Motor Corporation (Toyota) agreed today to study the possibility of collaborating on international space exploration. As a first step, JAXA and Toyota agreed to further cooperate on and accelerate their ongoing joint study*1 of a manned, pressurized rover*2 that employs fuel cell vehicle technologies. Such a form of mobility is deemed necessary for human exploration activities on the lunar surface. Even with the limited amount of energy that can be transported to the moon, the pressurized rover would have a total lunar-surface cruising range of more than 10,000 km.

International space exploration, aiming to achieve sustainable prosperity for all of humankind by expanding the domain of human activity and giving rise to intellectual properties, has its sights set on the moon and Mars. To achieve the goals of such exploration, coordination between unmanned missions, such as the recent successful touchdown by the asteroid probe Hayabusa2 on the asteroid Ryugu, and manned missions, such as those involving humans using pressurized rovers to conduct activities on the moon, is essential. When it comes to challenging missions such as lunar or Martian exploration, while various countries are competing in advancing their technologies, they are also advancing their cooperative efforts.

JAXA President Hiroshi Yamakawa had this to say today about the agreement between JAXA and Toyota: “At JAXA, we are pursuing international coordination and technological studies toward Japan’s participation in international space exploration. We aim to contribute through leading Japanese technologies that can potentially generate spin-off benefits. Having Toyota join us in the challenge of international space exploration greatly strengthens our confidence. Manned rovers with pressurized cabins are an element that will play an important role in full-fledged exploration and use of the lunar surface. For this, we would like to concentrate our country’s technological abilities and conduct technological studies. Through our joint studies going forward, we would like to put to use Toyota’s excellent technological abilities related to mobility, and we look forward to the acceleration of our technological studies for the realization of a manned, pressurized rover.”

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One of the key misconceptions about solar geoengineering—putting aerosols into the atmosphere to reflect sunlight and reduce global warming—is that it could be used as a fix-all to reverse global warming trends and bring temperature back to pre-industrial levels.

It can’t. Applying huge doses of to offset all warming from rising atmospheric C02 levels could worsen the problem—particularly rainfall patterns—in certain regions. But could smaller doses work in tandem with emission cuts to lower the risks of a changing climate?

New research from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), in collaboration with MIT and Princeton University, finds that if solar geoengineering is used to cut global temperature increases in half, there could be worldwide benefits without exacerbating change in any large geographic area.

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I know some people don’t like it but the Lunar Gateway is getting more traction.


The International Space Station partners have endorsed plans to continue the development of the Gateway, an outpost around the Moon that will act as a base to support both robots and astronauts exploring the lunar surface.

The Multilateral Coordination Board, which oversees the management of the Space Station, stressed its common hope for the Gateway to open up a cost-effective and sustainable path to the Moon and beyond.

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These days, it seems anyone wanting to launch rockets will inevitably be compared to Elon Musk and Jeff Bezos, especially if rocket launching isn’t the only business interest on the agenda. Musk has Tesla plus SpaceX, and Bezos has Amazon plus Blue Origin. Now, meet Mark Russell, a disciple of Bezos and rocket engineer who founded HyperSciences, a drilling company that uses aerospace technology to both quickly extract underground geothermal energy and put payloads into orbit at low cost.

The idea of leveraging Earth’s geothermal energy is not a new concept, but the expense and time required to reach the depth needed have been prohibitively expensive. That’s where HyperSciences comes in.

Russell and his team have developed a low-cost, multi-purpose projectile called the HyperDrone that can accelerate to velocities over five times the speed of sound and pulverize hard rock via their HyperDrill. This will enable tunneling speeds that are 5–10 times quicker than conventional methods, and more importantly, it opens up significant market viability in other industries that could benefit, namely when that acceleration is pointed skyward. NASA has already recognized this potential and is a current investor and major partner of HyperSciences.

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