Toggle light / dark theme

In air-breathing vertebrates, the circulatory and pulmonary systems contain separate networks of channels that intertwine but do not intersect with each other. Recreating such structures within cell-compatible materials has been a major challenge; even a single vasculature system can be a burden to create. Grigoryan et al. show that natural and synthetic food dyes can be used as photoabsorbers that enable stereolithographic production of hydrogels containing intricate and functional vascular architectures. Using this approach, they demonstrate functional vascular topologies for studies of fluid mixers, valves, intervascular transport, nutrient delivery, and host engraftment.

Science, this issue p. 458

Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study. We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. In addition, we deploy structured biodegradable hydrogel carriers in a rodent model of chronic liver injury to highlight the potential translational utility of this materials innovation.

Read more

Bruce Damer is a living legend and international man of mystery – specifically, the mystery of our cosmos, to which he’s devoted his life to exploring: the origins of life, simulating artificial life in computers, deriving amazing new plans for asteroid mining, and cultivating his ability to receive scientific inspiration from “endotripping” (in which he stimulates his brain’s own release of psychoactive compounds known to increase functional connectivity between brain regions). He’s about to work with Google to adapt his origins of life research to simulated models of the increasingly exciting hot springs origin hypothesis he’s been working on with Dave Deamer of UC Santa Cruz for the last several years. And he’s been traveling around the world experimenting with thermal pools, getting extremely close to actually creating new living systems in situ as evidence of their model. Not to mention his talks with numerous national and private space agencies to take the S.H.E.P.H.E.R.D. asteroid mining scheme into space to kickstart the division and reproduction of our biosphere among/between the stars…

Read more

Blue Origin, the space company of Jeff Bezos, completed a record breaking launch of its New Shepard rocket on Thursday.

Lifting off from Blue Origin’s facility in West Texas, the mission was the first time the company launched and landed one of its rockets five times. Additionally, the rocket sent a company record 38 research and development experiments to the edge of space.

Read more