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AI-designed T cell receptor substitutes can accelerate precision cancer immunotherapy

New designer proteins created using an AI tool can selectively target peptide segments that bind to markers on diseased cancer cells, acting like molecular flags that signal immune cells to attack and destroy the threats.

In a recent breakthrough, a team of researchers from the U.S. presented protein binders that specifically recognized the peptide portion of 11 diverse pMHCI complexes—amino-acid fragments found on the surface of almost all cells in the body that play a central role in the immune system’s ability to recognize and respond to abnormal or diseased cells, such as cancer cells.

These proteins, designed with the aid of AI, help human immune cells identify the correct targets and function more effectively, according to findings published in Science.

AI-powered headgear promises sharper focus from the comfort of home

A personalized brain stimulation system powered by artificial intelligence (AI) that can safely enhance concentration from home has been developed by researchers from the University of Surrey, the University of Oxford and Cognitive Neurotechnology. Designed to adapt to individual characteristics, the system could help people improve focus during study, work, or other mentally demanding tasks.

Published in npj Digital Medicine, the study is based on a patented approach that uses non-invasive brain alongside adaptive AI to maximize its impact.

The technology uses transcranial random noise stimulation (tRNS)—a gentle and painless form of electrical brain stimulation—and an AI algorithm that learns to personalize stimulation based on individual features, including level and head size.

AI-designed 3D materials enable custom control over how light bends

Refraction—the bending of light as it passes through different media—has long been constrained by physical laws that prevent independent control over how light waves along different directions bend. Now, UCLA researchers have developed a new class of passive materials that can be structurally engineered to “program” refraction, enabling arbitrary control over the bending of light waves.

In a study published in Nature Communications, a team led by Dr. Aydogan Ozcan, the Chancellor’s Professor of Electrical & Computer Engineering at UCLA, has introduced a called a refractive function generator (RFG) that can independently tailor the output direction of refracted light for each input direction. This device allows light to be steered, filtered, or redirected according to custom-designed rules—far beyond what standard materials or traditional metasurfaces can achieve.

Standard refraction, described by Snell’s law, links the input and output directions of light using fixed material properties. Even advanced metasurface designs only allow limited tunability of refraction.

Flaw in Gemini CLI AI coding assistant allowed stealthy code execution

A vulnerability in Google’s Gemini CLI allowed attackers to silently execute malicious commands and exfiltrate data from developers’ computers using allowlisted programs.

The flaw was discovered and reported to Google by the security firm Tracebit on June 27, with the tech giant releasing a fix in version 0.1.14, which became available on July 25.

Gemini CLI, first released on June 25, 2025, is a command-line interface tool developed by Google that enables developers to interact directly with Google’s Gemini AI from the terminal.

New 3D headset uses holograms and AI to create lifelike mixed reality visuals

Using 3D holograms polished by artificial intelligence, researchers introduce a lean, eyeglass-like 3D headset that they say is a significant step toward passing the “Visual Turing Test.”

“In the future, most virtual reality displays will be holographic,” said Gordon Wetzstein, a professor of electrical engineering at Stanford University, holding his lab’s latest project: a virtual reality display that is not much larger than a pair of regular eyeglasses. “Holography offers capabilities that we can’t get with any other type of display in a package that is much smaller than anything on the market today.”

Holography is a Nobel Prize-winning 3D display technique that uses both the reflecting from an object, as with a traditional photograph, and the phase of the light (the way the waves synchronize), to produce a hologram, a highly realistic three-dimensional image of the original object.

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