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Rethinking Consciousness: A Scientific Theory of Subjective Experience

If you’re interested in mind uploading, I have a book that I highly recommend. Rethinking Consciousness is a book by Michael S. A. Graziano, who is a Princeton University professor of psychology and neuroscience.

Early in his book Graziano writes a short summary:

“This book, however, is written entirely for the general reader. In it, I attempt to spell out, as simply and clearly as possible, a promising scientific theory of consciousness — one that can apply equally to biological brains and artificial machines.”

The theory is Attention Schema Theory.

I found this work compelling because one of the main issues in mind uploading is how do you make an inanimate object (like a robot or a computer) conscious? Graziano’s Attention Schema Theory provides a methodology.

After reading the book, be sure to read the Appendix, in which he writes:

“First, it serves as a tutorial on the attention schema theory. The underlying logic of the theory will be described in its simplest form. Second, I hope that the exercise will show engineers a general path forward for artificial consciousness.”

Keep exercising: New study finds it’s good for your brain’s gray matter

Cardiorespiratory exercise—walking briskly, running, biking and just about any other exercise that gets your heart pumping—is good for your body, but can it also slow cognitive changes in your brain?

A study in Mayo Clinic Proceedings from the German Center for Neurodegenerative Diseases provides new evidence of an association between and brain health, particularly in and total brain volume—regions of the brain involved with cognitive decline and aging.

Brain tissue is made up of gray matter and filaments called white matter that extend from the gray matter cells. The volume of gray matter appears to correlate with various skills and cognitive abilities. The researchers found that increases in peak oxygen uptake are strongly associated with increased gray matter volume.

Hearing through lip-reading

“Brain activity synchronizes with sound waves, even without audible sound, through lip-reading, according to new research published in JNeurosci.”

https://www.eurekalert.org/pub_re…/2020–01/sfn-htl010220.php

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Decoder translates brain activity into speech

Neurological conditions or injuries that result in the inability to communicate can be devastating. Patients with such speech loss often rely on alternative communication devices that use brain–computer interfaces (BCIs) or nonverbal head or eye movements to control a cursor to spell out words. While these systems can enhance quality-of-life, they can only produce around 5–10 words per minute, far slower than the natural rate of human speech.

Researchers from the University of California San Francisco today published details of a neural decoder that can transform brain activity into intelligible synthesized speech at the rate of a fluent speaker (Nature 10.1038/s41586-019‑1119-1).

“It has been a longstanding goal of our lab to create technology to restore communication for patients with severe speech disabilities,” explains neurosurgeon Edward Chang. “We want to create technologies that can generate synthesized speech directly from human brain activity. This study provides a proof-of-principle that this is possible.”

Brain imaging breakthrough predicts Alzheimer’s decline in early stages

Utilizing a recently developed brain imaging technique new research suggests that measuring accumulated levels of a protein called tau may predict future neurodegeneration associated with Alzihemer’s disease. The discovery promises to accelerate clinical trial research offering a novel way to predict the progression of the disease before major symptoms appear.

Exactly what occurs in the human brain during the earliest stages of Alzheimer’s disease remains quite a mystery for dementia researchers. While studies have homed in on several pathological signs signaling moderate to severe cases of Alzheimer’s, it’s still unclear what the initial triggers for the disease are, and without this vital information scientists are struggling to generate effective drugs and treatments to slow or prevent the disease.

The two big pathological signs of Alzheimer’s most researchers agree on are accumulations of amyloid and tau proteins in the brain. Abnormal aggregations of amyloid proteins, into what are referred to as plaques, are generally considered to be the primary causative mechanism behind Alzheimer’s. Masses of misfolding tau proteins, forming what are known as neurofibrillary tangles, are also seen in the disease.

Scientists Have Made Mini Brains That Behave Like Real Human Brains

Brain organoids are made from human pluripotent stem cells, which are cells that can become any kind of cell in the adult body. When the stem cells are introduced to certain chemicals, they can be coaxed into becoming brain cells, then put into a liquid with the nutrients they need to survive.

“The amazing thing is that, after this, they pretty much do everything alone,” says Alysson Muotri, a molecular biologist at UC San Diego. The cells self-assemble into spheres that contain neural progenitor cells, or cells that will become brain cells. Over the course of a few weeks, those cells turn into different kinds of neurons that can act just like neurons in the human brain.

In a study preprint published on bioRxiv and presented at the Society for Neuroscience conference last month, Muotri and his colleagues reported that they recorded spontaneous and complex electrical activity from their lab-grown mini brains. It’s the first time that brain organoids have spontaneously produced brain waves similar to human brain activity, Nature reported.

Finding the root of consciousness: Is this brain cell your ‘mind’s eye’?

Researchers believe they have identified specific neurons that are responsible for conscious awareness. Previous studies have implicated both thalamocortical circuits and cortico-cortico circuits in consciousness. The new study reports these networks intersect via L5p neurons. Directly activating L5p neurons made mice react to weaker sensory stimuli. The researchers say if consciousness requires L5p neurons, all brain activity without them must be unconscious.

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