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Category: neuroscience – Page 923

The Brain Isn’t Symmetrical — Researchers Reveal New Insight About the Brain

At first glance, the human body seems to be symmetrical: two arms, two legs, two eyes, two ears, and even the nose and mouth appear to be mirrored on an imaginary axis that divides most people’s faces. Finally, the brain is split into two nearly equal-sized halves, and the furrows and bulges follow a similar pattern. The initial impression, however, is misleading since there are small, functionally relevant differences between the left and right sides of the different brain regions.

The two hemispheres have distinct functional specializations. For instance, most individuals process language mostly in their left hemisphere whereas spatial attention is primarily processed in their right hemisphere. Work can thus be distributed more effectively to both sides, and the overall range of tasks is expanded.

However, this so-called lateralization, or the tendency for brain regions to process certain functions more in the left or right hemisphere, differs between people. And not only in the minority whose brains are mirror-inverted in comparison to the majority. Even people with classically arranged brains have varying degrees of asymmetry. Previous research has indicated that this, in turn, may have an effect on the functions themselves.

A Rare Phenomenon of Reversible Brain Shrinkage

European moles shrink their brains by 11% before the winter and grow them again by 4% by the summer.

European moles face an existential crisis in the depths of winter. Their high-limit mammal metabolisms need more food than is available during the coldest months. Instead of migrating or hibernating to deal with the seasonal challenge, moles have devised an unexpected energy-saving strategy: shrinking their brains.

In a recent study, a group from the Max Planck Institute of Animal Behavior headed by Dina Dechmann found that European moles shrink their brains by 11% before the winter and grow them back by 4% by summer. They are a new group of mammals known for reversibly shrinking their brains through a process known as Dehnel’s phenomenon.

A Novel Instructive Role for the Entorhinal Cortex

Summary: Researchers have identified a new type of synaptic plasticity they call behavioral timescale synaptic plasticity (BTSP). The study reveals how the entorhinal cortex sends instructive signals to the hippocampus and directs it to specifically reorganize the specific location and activity of a neural subset to achieve altered behavior in response to changes in environment and spatial cues.

Source: Texas Children’s Hospital.

A longstanding question in neuroscience is how mammalian brains (including ours) adapt to external environments, information, and experiences.

HUSH gene-silencing complex contributes to normal brain development and function

The gene-silencing complex HUSH might be involved in complex disorders affecting the brain and neurons. However, its mechanism of action remains unclear. Researchers from the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) now uncover the in vivo targets and physiological functions of a component of the HUSH gene-silencing complex and one of its associated proteins.

The work, conducted in laboratory mouse models and human organoids, links the HUSH complex to normal , neuronal individuality and connectivity, as well as mouse behavior. The findings are published in Science Advances.

The human silencing hub (HUSH) complex was recently identified to be of key importance for silencing repetitive genetic elements including transposons in mammals. The HUSH complex contains MPP8, a protein that binds the histone modification mark H3K9me3. Additionally, HUSH is known to recruit other proteins including the zinc finger protein MORC2.

Organoids Reveal How SARS-CoV-2 Damages Brain Cells — and a Potential Treatment

Using human brain organoids, an international team of researchers, led by scientists at University of California San Diego School of Medicine and Sanford Consortium, has shown how the SARS-CoV-2 virus that causes COVID-19 infects cortical neurons and specifically destroys their synapses — the connections between brain cells that allow them to communicate with each other.

The findings, published in the November 3, 2022 issue of PLOS Biology, also report that the antiviral drug sofosbuvir, already an approved treatment for hepatitis C, effectively inhibited SARS-CoV-2 replication and reversed neuronal alterations in infected brain organoids.

“Vaccines and emerging treatments have reduced the health consequences of COVID-19 in most patients,” said senior study author Alysson R. Muotri, PhD, professor in departments of Pediatrics and Cellular and Molecular at UC San Diego School of Medicine. “But the phenomenon of Long COVID, characterized by persisting symptoms that include neurological impairment, remains poorly understood and without any specific remedy.

Brett Anderson, MSG, MSW — Journey From Rock Musician To Rethinking Aging, Longevity & Mental Health

Is a Gerontologist and Clinical Social Worker on a mission to rethink aging, longevity & mental health.

Ms. Anderson was also the former lead singer of the American Rock group, The Donnas (https://en.wikipedia.org/wiki/The_Donnas), where she was the lead vocalist for 20 years, performing throughout the U.S., as well as internationally, and had performances / appearances on major network shows including Saturday Night Live, David Letterman and Late Night with Conan O’Brien.

Ms. Anderson received her bachelor’s degree in Psychology at Stanford University, her MSG, Gerontology from the USC Leonard Davis School of Gerontology, and her Master of Social Work — MSW, from the.
UCLA Luskin School of Public Affairs.

Now pursuing a career as a licensed geriatric social worker, Ms. Anderson hopes to integrate her creative and business experience, with her gerontological knowledge, to better meet the needs of our rapidly aging population.

New Molecule Destroys Alzheimer’s-Causing Amyloid Tangles

A molecule found in green tea helped UCLA biochemists in the discovery of multiple molecules capable of destroying tau fibers.

University of California, Los Angeles (UCLA) researchers used a molecule present in green tea to uncover more molecules that may break up protein tangles in the brain, which are known to cause Alzheimer’s.

Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.

Brain Complexity and Consciousness

Read the accompanying news item: https://www.humanbrainproject.eu/en/follow-hbp/news/ebrains-…disorders/

Using the EBRAINS research infrastructure, scientists of the Human Brain Project have developed multi-scale simulations of the human brain that mimic hallmarks of activity during wake and deep sleep states. Such simulations can lead to a better understanding of biological mechanisms that regulate human consciousness and its disorders, which span from single neurons to whole brain scales.

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