Lifeboat Foundation

Today I’m announcing a $100M commitment to Kernel in an effort to enhance human intelligence and reimagine our future. Unlocking our brain is the most significant and consequential opportunity in history — and it’s time sensitive.

We’re starting to identify the mechanisms underlying neural code and make them programmable. Our biology and genetics have become increasingly programmable; our neural code is next in line. Programming our neural code will enable us to author ourselves and our existence in ways that were previously unimaginable.

I started Kernel in 2016 (read more at the Washington Post) to build the world’s first neural prosthetic for human intelligence enhancement. The investment I’m making in Kernel today will expedite the development of this prosthetic and similarly transformative neurotechnologies.

Continue reading “Kernel’s Quest to Enhance Human Intelligence” »

Get ready to dump the keyboard: Experts claim mind controlled computers are just a decade away…

An expert at West Virginia University suggests human thought will soon communicate directly with computers, which will move us toward an era of ‘computing at the speed of thought.’

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It would be the ultimate user interface: a device the size of two stacked nickels that allows your thoughts to control computers. The only catch is it’ll have to be implanted in your brain.

Earlier this year, former Braintree founder Bryan Johnson publicly announced his plans to forge Kernel, a company with the sole purpose of building hardware and software to augment human intelligence. Today, Johnson is investing $100 million of his own money into the concept, looking to rapidly double the size of his team, shore up a portfolio of intellectual property and prepare for animal and human testing trials for a forthcoming device aimed at reducing cognitive deficiencies for sufferers of conditions like Alzheimer’s and dementia.

Kernel is still very much in the planning stages, but the idea is rooted in the research of Theodore Berger, the company’s chief science officer. The futuristic device, which Johnson says might actually not need to be implanted beneath the skull at all, is designed to facilitate communication between brain cells by hacking the “neural code” that enables our brain to store and recall key information. With proper implementation, such a device could correct faulty signals to mend a cognitive impairment.

“We have done this before with biology and genomics,” said Johnson in an interview. “We can program yeast to do a specific function. We can expect the same path with neural code.”

Continue reading “Bryan Johnson invests $100 million in Kernel to unlock the power of the human brain” »

Scientists at Boston Children’s Hospital identified a defect that causes a genetic disorder in 50% of autism sufferers — and two existing classes of drugs that counter the defect.

Studies of different animal species suggest a link between eating less and living longer, but the molecular mechanisms by which caloric restriction affords protection against disease and extends longevity are not well understood.

New clues to help solve the mystery are presented in an article published in the September issue of Aging Cell by scientists at the Center for Research on Redox Processes in Biomedicine (Redoxoma), one of the Research, Innovation and Dissemination Centers (RIDCs) funded by FAPESP.

The results of in vitro and in vivo experiments performed by the Redoxoma team included the finding that a 40% reduction in dietary caloric intake increases mitochondrial calcium retention in situations where intracellular calcium levels are pathologically high. In the brain, this can help avoid the death of neurons that is associated with Alzheimer’s disease, Parkinson’s disease, epilepsy and stroke, among other neurodegenerative conditions.

PCG-1α therapy shows promise in treating age-related decline.

It is always a good idea to look closely at the biochemistry involved in any potential Alzheimer’s disease therapy that shows promise in mouse models. There is perhaps more uncertainty for Alzheimer’s than most other age-related conditions when it comes to the degree to which the models are a useful representation of the disease state in humans — which might go some way towards explaining the promising failures that litter the field. In the research here, the authors are aiming to suppress a step in the generation of amyloid-β, one of the proteins that aggregates in growing amounts and is associated with brain cell death in Alzheimer’s disease. They achieve this goal using gene therapy to increase the level of PGC-1α, which in turn reduces the level of an enzyme involved in the production of amyloid-β. Interestingly, increased levels of PGC-1α have in the past been shown to produce modest life extension in mice, along with some of the beneficial effects to health associated with calorie restriction.

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Continue reading “PGC-1α Gene Therapy Slows Alzheimer’s Progression in Mouse Model” »

Athletes with disabilities have been competing in a range of challenges that use assistive technology to overcome day-to-day practical challenges.

Bionic arms, powered exoskeletons, brain-controlled computer interfaces and supercharged wheelchairs all featured at the world’s first Cybathlon, near Zurich, Switzerland.

One of the races saw functional electrical stimulation (FES) used to activate the leg muscles of paralysed competitors to ride bikes.

It’s impressive enough that our human brains are made up of the same ‘star stuff’ that forms the Universe, but new research suggests that this might not be the only thing the two have in common.

Just like the Universe, our brains might be programmed to maximise disorder — similar to the principle of entropy — and our consciousness could simply be a side effect.

The quest to understand human consciousness — our ability to be aware of ourselves and our surroundings — has been going on for centuries. Although consciousness is a crucial part of being human, researchers still don’t truly understand where it comes from, and why we have it.

Continue reading “Consciousness could be a side effect of ‘entropy’, say researchers” »