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Big initiatives to understand the workings of the brain

Neuroscience has a data problem. In our efforts to understand the brain researchers are generating ever greater amounts of data. The problem is, how can they gain meaning from it?

A recent study, that used functional magnetic resonance imaging (fMRI) data to produce the most detailed map to date of the human cortex, looked at data from 210 peoples’ brains. The researchers estimated that equated to 30 gigabytes of data per participant. Meaning over 6 terabytes of data were analyzed to form the map, and this was a study of a large section of cortex, not the whole brain.

Elon Musk Says First Demo Of His Brain Chip Is Coming This Friday

Elon Musk’s controversial ‘brain chip’ might be coming to us sooner than we first thought, with the technology entrepreneur promising a working demo by the end of this week.

The news comes a little over a month after Musk announced his latest start-up, Neuralink, was in the process of developing a brain-computer interface that allegedly has a life-changing range of benefits – including the ability to stream music straight into your brain.

Now, Neuralink, which has already received more than $158 million in funding, will be demonstrating a working device this coming Friday, August 28, at approximately 6.00pm ET (11.00pm BST).

Scientists Find Evidence The Human Brain Can Create Structures in Up to 11 Dimensions

Back in 2017, neuroscientists used a classic branch of maths in a totally new way to peer into the structure of our brains.

What they discovered is that the brain is full of multi-dimensional geometrical structures operating in as many as 11 dimensions.

We’re used to thinking of the world from a 3D perspective, so this may sound a bit tricky, but the results of this study could be the next major step in understanding the fabric of the human brain — the most complex structure we know of.

How language shapes the way we think

You’ll be surprised by how much your language shapes your perspective.

There are about 7,000 languages spoken around the world — and they all have different sounds, vocabularies and structures. But do they shape the way we think? Cognitive scientist Lera Boroditsky shares examples of language — from an Aboriginal community in Australia that uses cardinal directions instead of left and right to the multiple words for blue in Russian — that suggest the answer is a resounding yes. “The beauty of linguistic diversity is that it reveals to us just how ingenious and how flexible the human mind is,” Boroditsky says. “Human minds have invented not one cognitive universe, but 7,000.”

This talk was presented at an official TED conference, and was featured by our editors on the home page.

Study leads to potential for new treatment approach to Alzheimer’s

Research looking at a possible new therapeutic approach for Alzheimer’s disease was recently published in the Journal of Neuroinflammation. The paper out of the University of Kentucky’s Sanders-Brown Center on Aging (SBCoA) is titled “Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition”. The work looked at targeting inflammation by using an antibody. Alzheimer’s disease and related dementias have no disease-modifying treatments at this time and represent a looming public health crisis given the continually growing aging population.

The paper explains that current therapeutic approaches to the treatment of Alzheimer’s focus on the major pathological hallmarks of the disease which are and neurofibrillary tangles. They are the requirements for a diagnosis of Alzheimer’s disease. However, the authors say there has been an explosion of genetic data suggesting the risk for sporadic Alzheimer’s disease is driven by several other factors including neuroinflammation, membrane turnover and storage, and .

In this study the researchers focused on triggering receptor expressed on myeloid cell-2 (TREM2). “TREM2 was identified several years ago as a gene that, when there’s a mutation, significantly increases risk of Alzheimer’s disease. The field thinks that this mutation reduces the function of the receptor, so we hypothesized that targeting TREM2 to increase its function might be a valid treatment for Alzheimer’s,” explained Donna Wilcock, SBCoA associate director.

The US military is trying to read minds

Elon Musk’s Neuralink will likely show off its design for a brain-computer interface Friday evening. The concept it unveiled last summer involves surgically implanting it into the brain to detect the activity of neurons. The US military also wants to develop a brain-computer interface, as we explain in this story from October. But here’s the kicker: no surgery required—and the device could be put on and taken off like a helmet or headband.

In August, three graduate students at Carnegie Mellon University were crammed together in a small, windowless basement lab, using a jury-rigged 3D printer frame to zap a slice of mouse brain with electricity.

The brain fragment, cut from the hippocampus, looked like a piece of thinly sliced garlic. It rested on a platform near the center of the contraption. A narrow tube bathed the slice in a solution of salt, glucose, and amino acids. This kept it alive, after a fashion: neurons in the slice continued to fire, allowing the experimenters to gather data. An array of electrodes beneath the slice delivered the electric zaps, while a syringe-like metal probe measured how the neurons reacted. Bright LED lamps illuminated the dish. The setup, to use the lab members’ lingo, was kind of hacky.

Neuralink event: what to know about Elon Musk’s highly-anticipated reveal

NEURALINK, ELON MUSK’S HUMAN-BRAIN LINKUP FIRM, WILL HOLD AN EVENT THIS WEEK – and it’s expected to feature a demonstration of the brain’s neurons firing in real-time.

The secretive firm has been relatively quiet since its first public event in July 2019, when Musk and his team explained how the firm plans to use chips to link human brains up to computers. In July 2020, Musk revealed that the company was planning a second event for Friday, August 28. He also reiterated the company’s mission statement: “If you can’t beat ‘em, join ‘em.”

Neuralink is set to hold its next event this week. Here’s what you need to know about the human-brain linkup firm’s plans.

When Host Diets Are Lacking, Gut Bacteria Pull Together To Survive

To study how the microbiome affects their host behavior, a group of researchers at the Champalimaud Centre used the fruit fly combined with high-tech tools to show that two gut bacteria establish a metabolic cross-feeding that enables them to grow in diets that lack the nutrients that are essential for their growth and to allow them to change host decision making and reproduction. Results reveal a mechanism through which the right combination of bacteria can lead to microbiome resiliency to dietary perturbations and changes in brain function.

New research reveals a mechanism through which the right combination of bacteria can lead to microbiome resiliency to dietary perturbations.

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