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Tone of voice matters in neuronal communication

WOODS HOLE, Mass. — The dialogue between neurons is of critical importance for all nervous system activities, from breathing to sensing, thinking to running. Yet neuronal communication is so fast, and at such a small scale, that it is exceedingly difficult to explain precisely how it occurs. A preliminary observation in the Neurobiology course at the Marine Biological Laboratory (MBL), enabled by a custom imaging system, has led to a clear understanding of how neurons communicate with each other by modulating the “tone” of their signal, which previously had eluded the field. The report, led by Grant F. Kusick and Shigeki Watanabe of Johns Hopkins University School of Medicine, is published this week in Nature Neuroscience.

In 2016 Watanabe, then on the Neurobiology course faculty, introduced students to the debate over how many synaptic vesicles can fuse in response to one action potential (see this 2-minute video for a quick brush-up on neurotransmission). To probe this controversy, they used a “zap-and-freeze” imaging technology conceived by co-authors M. Wayne Davis, Watanabe and Erik Jorgensen, and built by Leica for testing in the Neurobiology course. They zapped a neuron with electricity to induce an action potential, then quickly froze the neuron and took an image. They saw multiple vesicles fusing at once at many synapses, the first novel finding of this Nature Neuroscience report.

But there was more. Back at Johns Hopkins, Kusick and Watanabe decided to walk through the neurotransmission process with zap-and-freeze, taking images every 3 milliseconds after the action potential. That’s when they found an answer to an even larger question — how do neurons change the tone of their neurotransmission signal?

How the Brain Balances Emotion and Reason

Summary: Area 32, a region of the anterior cingulate, balances activity from cognitive and emotional areas of the primate brain.

Source: SfN

Navigating through life requires balancing emotion and reason, a feat accomplished by the brain region “area 32” of the anterior cingulate cortex. The area maintains emotional equilibrium by relaying information between cognitive and emotional brain regions, according to new research in monkeys published in Journal of Neuroscience.

Multiple Unapproved Drugs Found in “Brain Boosting” Supplements

Researchers identified five unapproved drugs in dangerous combinations and doses in over-the-counter cognitive enhancement drugs. Side effects of the unapproved drugs include increases and decreases in blood pressure, agitation, and sedation.approved drugs in dangerous combinations and doses in over-the-counter cognitive enhancement drugs. Side effects of the unapproved drugs include increases and decreases in blood pressure, agitation, and sedation.approved drugs in dangerous combinations and doses in over-the-counter cognitive enhancement drugs. Side effects of the unapproved drugs include increases and decreases in blood pressure, agitation, and sedation.

Theology of Digital Physics: The Universe of Conscious Minds

#DigitalTheology #TheologyofDigitalPhysics #PhenomenalConsciousness #CosmicSelf #HolographicPrinciple #DigitalPhysics #theology #pantheism #consciousness


Since we live in a world which isn’t random, but organized at every level, a role for consciousness seems unavoidable. The ‘digital theologian’ shows us compelling evidence from quantum mechanics, mathematics and computer sciences, which not only aligns with a philosophical worldview of the Primacy of Consciousness, but which also assigns a role to information as its modus operandi.

It is quantum mechanics which appears to connect the Universe as a whole to consciousness. A whole, which is more than the sum of its parts and irreducible to mere assumptions deriving from the anatomizing dissection into mental confabulations. Drawing from the holographic principle, perceptroniums and noocentrism, Alex provides crucial keys to unlock the mystery of consciousness to show us how our local consciousness can arise from a non-local cosmic consciousness network.

Carefully building his fortress of arguments, Alex gathers his building bricks from various areas of scientific exploration, ranging from the role of language and tools in the development of our consciousness, the physics of time and epigenetics. Traditional Darwinism and reductive materialism become so challenged, that we become bound to agree with Terence McKenna’s statement that “object fetishism is completely bankrupt.” All these threads are then skillfully woven into the irresistible attractor and only logical conclusion, or Digital Pantheism and Omega Point Cosmology. And with this thus synthesized Apotheosis, Vikoulov brings the architecture of his chef-d’oeuvre to full fruition.

A Genetic Variant That Protects Against Alzheimer’s Promotes Immune Cell Functions

Summary: PLCG2-P522R, a genetic variant that protects against Alzheimer’s disease, enhances key functions of immune cells.

Source: University of Eastern Finland

A new study conducted by researchers at the University of Eastern Finland found that the PLCG2-P522R genetic variant, which protects against Alzheimer’s disease, enhances several key functions of immune cells. The results obtained in the study highlight the importance of immune cells as a target of future development of new therapies for Alzheimer’s disease.

160 Genes Linked to Brain Shrinkage in Study of 45,000 Adults

Researchers have identified 160 genes linked to brain shrinkage in adults. The genes appear to be involved in brain development, vascular and neurodegenerative diseases, and some psychiatric conditions.0 genes linked to brain shrinkage in adults. The genes appear to be involved in brain development, vascular and neurodegenerative diseases, and some psychiatric conditions.0 genes linked to brain shrinkage in adults. The genes appear to be involved in brain development, vascular and neurodegenerative diseases, and some psychiatric conditions.

Kitty see, kitty do: cat imitates human, in first scientific demonstration of behavior

In 16 subsequent trials, Ebisu accurately copied her owner more than 81% of the time, the team reports this month in (see video, above). The fact that the cat used her paw and face to touch the box when her owner used her hand and face, respectively, indicates she was able to “map” her owner’s body parts onto her own anatomy, the team says.

Fugazza says only dolphins, parrots, apes, and killer whales have so far been shown to imitate people. Cats having the same ability, she says, suggests it may be widespread in the animal kingdom, evolving early in animal evolution. And even though the study was conducted on a single cat, Fugazza thinks it’s likely that most cats can imitate people. “I don’t think Ebisu was a genius.”

But Claudio Tennie, an ethologist at the University of Tübingen who has studied cognition in dogs and primates, is not impressed. He says it’s impossible to tell from the study whether cats have an innate ability to imitate humans, or whether the intensive “Do as I do” training gave them the skill. “We can train bears to ride motorcycles,” he says. “That doesn’t mean bears ride motorcycles.”

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