Lifeboat Foundation

Summary: A new treatment that uses extracellular vesicles filled with exosomes derived from human stem cells could help repair brain damage following stroke, researchers report.

Source: University of Georgia.

A team of researchers at the University of Georgia’s Regenerative Bioscience Center and ArunA Biomedical, a UGA startup company, have developed a new treatment for stroke that reduces brain damage and accelerates the brain’s natural healing tendencies in animal models. They published their findings in the journal Translational Stroke Research.

Geneticists are starting to unpick what causes psychiatric conditions like schizophrenia and bipolar disorder, and even some autism-like developmental conditions.

New Whitehead Institute research may prove to be a useful paradigm for targeting diseases caused by abnormal methylation. Credit: Steven Lee/Whitehead Institute Fragile X syndrome is the most frequent cause of intellectual disability in males, affecting one out of every 3,600 boys born. The syndrome can also cause autistic traits, such as social and communication deficits, as well as attention problems and hyperactivity. Currently, there is no cure for this disorder. Fragile X syndrome is caused by mutations in the FMR1 gene on the X chromosome, which prevent the gene’s expression. This abs…

This Purkinje neuron was derived from patients with tuberous sclerosis and model properties of the disease at the cellular and molecular level. Sundberg and colleagues first created induced pluripotent stem cells (iPSCs) from patients’ blood cells or skin cells, then differentiated them into neural progenitor cells and finally Purkinje cells. Credit: Courtesy Maria Sundberg, PhD, Sahin Laboratory, Boston Children’s Hospital Increasing evidence has linked autism spectrum disorder (ASD) with dysfunction of the brain’s cerebellum, but the details have been unclear. In a new study, researchers…

An experimental treatment completely reversed Alzheimer’s disease in mice by reducing the levels of a single enzyme in the animals’ brains. The results further bolster the theory that amyloid plaques are at the root of this mysterious brain disease, and that addressing these plaques could lead to an eventual cure for Alzheimer’s. The study, published February 14 in the Journal of Experimental Medicine, found that slowly reducing levels of the enzyme BACE1 in mice as they aged either prevented or reversed the formation of amyloid plaques in the brain, a hallmark sign of Alzheimer’s disease…

New Alzheimer’s blood test is so precise, it could predict it three decades ahead. The test was accurate in 90% of patients tested.

Summary: Recent scientific advances in anti-aging science are bringing the dream of the fountain of youth closer to reality. More than just extending our lifespans, the field hopes to significantly reduce the chronic diseases of aging, such as cancer, heart disease, and dementia. [This article first appeared on the website LongevityFacts.com. Author: Brady Hartman. ]

A fountain of youth has been the dream of humanity throughout history.

Recent scientific advances are bringing that dream closer to reality.

Continue reading “Anti-Aging Scientists Hope to Reduce Chronic Diseases” »

Summary: A recently announced parabiosis trial in humans – the practice of transfusing young blood to old – may have profound implications for treating the chronic diseases of old age, including metabolic changes, frailty, Alzheimer’s, Parkinson’s, and other forms of dementia. However, some geroscientists say that variations of the procedure could cause severe side effects. [This article first appeared on the website LongevityFacts.com. Author: Brady Hartman. ]

The idea that youthful blood might rejuvenate our aging bodies has lingered in the popular imagination for centuries, fueled by recent experiments in which these transfusions revitalized aging mice.

Last week, Bill Faloon of the Life Extension Foundation (LEF) in partnership with the Young Blood Institute (YBI), announced a bold new human trial of the rejuvenating effects of the young blood / old blood swap, saying.

Continue reading “Can the blood of teens rejuvenate our bodies? This new trial aims to find out” »

MIT 6.S099: Artificial General Intelligence class takes an engineering approach to exploring possible research paths toward building human-level intelligence. The lectures introduce our current understanding of computational intelligence and ways in which strong AI could possibly be achieved, with insights from deep learning, reinforcement learning, computational neuroscience, robotics, cognitive modeling, psychology, and more.

Lex Fridman

Continue reading “Future of Intelligence (Ray Kurzweil)” »