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Category: neuroscience – Page 794


James W. Clement is a longevity researcher who was the 12th person on the planet to have his DNA sequenced. In 2010 James launched his Supercentenarian Research Study, which he started in 2010 with Professor George M. Church of Harvard Medical School. Since then Clement has read 20,000 medical research papers on longevity and has acquired one of the largest DNA databases of supercentenarians, the youngest of whom is 106 years old. Most recently James W. Clement is the author of the Switch: Ignite your metabolism with intermittent fasting, protein cycling, and keto. Finally, I know James personally and have gone to visit his previous research lab in Apple Valley, California, so I can honestly say that he is among the most humble humans and the hardest-working longevity researchers that I have ever seen. I have learned a lot from Clement and I hope you do too.

During this 2 hour interview with James W. Clement, we cover a variety of interesting topics such as: Clement’s journey from being a lawyer to becoming a full-time longevity researcher; the name and story behind Better Humans; why James is a transhumanist; why we have to first make it to 100 before we start taking “magic pills”; the switch between mTOR and autophagy; the importance of intermittent fasting, its time and duration; the connection between gut bacteria and dopamine; why the biggest problem of our diet is the overconsumption of both dairy and meat; protein cycling and why we can’t sustain autophagy indefinitely; the dangers of coconut oil; why all centenarian blue zones in the world eat high-carb diets and why we should try keto.

My favorite quote that I will take away from this interview with James W. Clement is:

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Magnetic resonance imaging is no longer confined to radiology departments. The U.S. Food and Drug Administration announced Wednesday that it has provided clearance to the “world’s first” bedside MRI system, according to an announcement.

Hyperfine said it will begin shipping its portable, low-field modalities this summer. It’s 510(k) clearance falls on the same day that Yale researchers reported the device can accurately and safely image patient’s brains for stroke. Those preliminary results are set to be presented next week at the American Stroke Association’s International conference in Los Angeles, the group announced.

“We’ve flipped the concept from having to get patients to the MRI to bringing the MRI to the patients,” said Kevin Sheth, MD, senior author and a chief physician at Yale School of Medicine. “This early work suggests our approach is safe and viable in a complex clinical care environment.”

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Later today I’ll lose consciousness for a few hours to rest and repair. There’s a good chance you will, too. Yet as ubiquitous as sleep is, we know very little about which parts of the brain are fundamental to staying awake.

Thanks to a recent experiment that stimulated the brains of anaesthetised macaques, we have a clearer idea of just which neurological structures might be primarily responsible for switching us on each day.

The results not only help us to better understand the processes behind anaesthesia; for those trapped in vegetative or comatose states by illness or injury it could mean a pathway out again.

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Yes, you can detect another person’s consciousness. Christof Koch described a method called ‘zap and zip’. Transcranial magnetic stimulation is the ‘zap’. Brain activity is detected with an EEG and analyzed with a data compression algorithm, which is the ‘zip’. Then the value of the perturbational complexity index (PCI) is calculated. If the PCI is above 0.31 then you are conscious. If the PCI is below 0.31 then you are unconscious. If this link does not work then go to the library and look at the November 2017 issue of Scientific American. It is the cover story.

Zapping the brain with magnetic pulses while measuring its electrical activity is proving to be a reliable way to detect consciousness.

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Dr. Theodore Ho talks about the rapidly expanding possibilities of stem cells to be used in reversing or slowing the aging process. He discusses his previous and current work with the brain, including such methods as tissue clearing, multifiber photometry and optogenetics, and single resolution calcium imaging and control. Dr. Ho is a neuroscientist and stem cell biologist studying the mechanisms and causes of biological aging and potential strategies to slow or reverse them, in order to prevent the onset of age

Associated diseases to help us live healthier and longer lives.

He completed a four-year joint bachelor’s/master’s degree program in.

Human developmental and regenerative biology/bioengineering at.

Harvard University, and he received his PhD in Biophysics from the.

University of California San Francisco, studying stem cell aging in the lab of Dr. Emmanuelle Passegue. In college he developed a nanoparticle drug delivery system, in graduate school he discovered previously unknown mechanisms of cellular and molecular aging of stem cells, and now in the Deisseroth lab he is using optical recording and perturbation of neuronal activity to study neural circuit dynamics that control behavior. This talk was given at a TEDx event using the TED conference format but independently organized by a local community.

Continue reading “Aging and Stem Cells | Theodore Ho | TEDxMiddlebury” | >

The FDA has cleared the world’s first portable MRI system, designed to be wheeled to a hospital bedside for scanning a patient’s head and brain.

Developed by Hyperfine Research for people age two and older, the point-of-care imaging system weighs about one-tenth that of a conventional, fixed MRI system. About three feet wide and five feet tall, the device fits in an elevator and runs off an everyday power outlet to create both clinical contrast images and 3D renders.

“More than 40 years after its first use, MRI remains a marvel. Unfortunately, it also remains inaccessible,” Hyperfine Chief Medical Officer Khan Siddiqui said in a statement. “It’s time that MRI made the jump to point of need just like X-ray and ultrasound have before it.”

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Glioblastomas are relentless, hard-to-treat, and often lethal brain tumors. Yale scientists have enlisted a most unlikely ally in efforts to treat this form of cancer — elements of the Ebola virus.

“The irony is that one of the world’s deadliest viruses may be useful in treating one of the deadliest of brain cancers,” said Yale’s Anthony van den Pol, professor of neurosurgery, who describes the Yale efforts Feb. 12 in the Journal of Virology.

The approach takes advantage of a weakness in most cancer tumors and also of an Ebola defense against the immune system response to pathogens.

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