Lifeboat Foundation

At the moment, minibrains are far from anything approaching moral personhood in a dish, and the technology may never come close. But the rapid pace of progress on organoids has led scientists and ethicists to call for a public ethical discussion that can move in tandem with the research.

Human ‘minibrains’ are far from conscious, but scientists say it’s time to talk about ethics.

The ability to reverse ageing is something many people would hope to see in their lifetime. This is still a long way from reality, but in our latest experiment, we have reversed the ageing of human cells, which could provide the basis for future anti-degeneration drugs.

Ageing can be viewed as the progressive decline in bodily function and is linked with most of the common chronic diseases that humans suffer from, such as cancer, diabetes and dementia. There are many reasons why our cells and tissues stop functioning, but a new focus in the biology of ageing is the accumulation of “senescent” cells in the tissues and organs.

Senescent cells are older deteriorated cells that do not function as they should, but also compromise the function of cells around them. Removal of these old dysfunctional cells has been shown to improve many features of ageing in animals such as the delayed onset of cataracts.

Continue reading “Ageing in Human Cells Successfully Reversed in the Lab” »

A drug which has been used to treat liver disease for decades could help to restore cells damaged by Alzheimer’s, a new study from the University of Sheffield has found.

The pioneering study, funded by Alzheimer’s Research UK, discovered the drug ursodeoxycholic acid (UDCA) improves mitochondrial dysfunction – which is known to be a causative factor for both sporadic and familial Alzheimer’s disease.

Mitochondria play a pivotal role in both neuronal cell survival and death as they regulate energy metabolism and cell death pathways acting as a cell’s battery.

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Did you know you have tiny tunnels in your head? That’s OK, no one else did either until recently! But that’s exactly what a team of medical researchers have just found in mice and humans — tiny channels that connect skull bone marrow to the lining of the brain.

The research shows they may provide a direct route for immune cells to rush from the marrow into the brain in the event of damage.

Previously, scientists had thought immune cells were transported via the bloodstream from other parts of the body to deal with brain inflammation following a stroke, injury, or brain disorder.

Continue reading “Scientists Have Found Secret Tunnels Between The Skull And The Brain” »

The neuron is not found within lab mice, possibly explaining why mouse studies often do not translate to human brains.

Researchers have found a way to rebuild damaged nerve coverings that cause Multiple Sclerosis.

Researchers successfully used a synthetic compound to stimulate a receptor pathway to promote remyelination in the brain. The technique may have significant beneficial implications for treating multiple sclerosis, researchers say.

When it comes to fundamental physics, things can get spooky. At least that’s what Albert Einstein said when describing the phenomenon of quantum entanglement—the linkage of particles in such a way that measurements performed on one particle seem to affect the other, even when separated by great distances. “Spooky action at a distance” is how Einstein described what he couldn’t explain.

While quantum mechanics includes many mysterious phenomena like entanglement, it remains the best fundamental physical theory describing how matter and light behave at the smallest scales. Quantum theory has survived numerous experimental tests in the past century while enabling many advanced technologies: modern computers, digital cameras and the displays of TVs, laptops and smartphones. Quantum entanglement itself is also the key to several next-generation technologies in computing, encryption and telecommunications. Yet, there is no clear consensus on how to interpret what quantum theory says about the true nature of reality at the subatomic level, or to definitively explain how entanglement actually works.

According to Andrew Friedman, a research scientist at the University of California San Diego Center for Astrophysics and Space Sciences (CASS), “the race is on” around the globe to identify and experimentally close potential loopholes that could still allow alternative theories, distinct from quantum theory, to explain perplexing phenomena like quantum entanglement. Such loopholes could potentially allow future quantum encryption schemes to be hacked. So, Friedman and his fellow researchers conducted a “Cosmic Bell” test with polarization-entangled photons designed to further close the “freedom-of-choice” or “free will” loophole in tests of Bell’s inequality, a famous theoretical result derived by physicist John S. Bell in the 1960s. Published in the Aug. 20 issue of Physical Review Letters, their findings are consistent with quantum theory and push back to at least 7.

Continue reading “Physicists race to demystify Einstein’s ‘spooky’ science” »

Hidden tunnels which link the human skull to the brain have been discovered by scientists, leading to hopes the breakthrough may help in stroke and Alzheimer’s research.

Researchers believe that the passages provide a quick channel for immune cells to reach the brain from the bone marrow in the skull.

Previously it was through that immune cells formed in the bone marrow of the limbs was transported up to the brain to clear out infection.

Continue reading “Secret immune cell tunnels found in human skulls” »

If you’ve ever experienced jet lag, you are familiar with your circadian rhythm, which manages nearly all aspects of metabolism, from sleep-wake cycles to body temperature to digestion. Every cell in the body has a circadian clock, but researchers were unclear about how networks of cells connect with each other over time and how those time-varying connections impact network functions.

In research published Aug. 27 in PNAS, researchers at Washington University in St. Louis and collaborating institutions developed a unified, data-driven computational approach to infer and reveal these connections in biological and chemical oscillatory networks, known as the topology of these complex networks, based on their time-series data. Once they establish the topology, they can infer how the agents, or cells, in the network work together in synchrony, an important state for the brain. Abnormal synchrony has been linked to a variety of brain disorders, such as epilepsy, Alzheimer’s disease and Parkinson’s disease.

Jr-Shin Li, professor of systems science & mathematics and an applied mathematician in the School of Engineering & Applied Science, developed an algorithm, called the ICON (infer connections of networks) method, that shows for the first time the strength of these connections over time. Previously, researchers could only determine whether a connection existed between networks.