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Category: neuroscience – Page 775

Genes for Regulating Stem Cell Aging Identified

Advanced, others might like.

The exact gene that caused stem cell aging has been identified.

Above – When mesenchymal stem/stromal cells (MSCs) age, the transcription factor GATA6 is increasingly produced in the cell to induce aging response. By transcription factor-based cellular reprogramming, aged MSCs are rejuvenated with a reduction in GATA6 effects on cellular aging. CREDIT AlphaMed Press

University of Wisconsin-Madison researchers found that the expression of GATA6, a protein that plays an important role in gut, lung and heart development, was repressed in the reprogrammed cells compared to the control cells. This repression led to an increase in the activity of a protein essential to embryonic development called sonic hedgehog (SHH) as well as the expression level of yet another protein, FOXP1, necessary for proper development of the brain, heart and lung. “Thus, we identified the GATA6/SHH/FOXP1 pathway as a key mechanism that regulates MSC aging and rejuvenation,” Dr. Li said.

French army gets ethical go-ahead for bionic soldiers

The French armed forces now have permission to develop “augmented soldiers” following a report from a military ethics committee.

The report, released to the public on Tuesday, considers medical treatments, prosthetics and implants that improve “physical, cognitive, perceptive and psychological capacities,” and could allow for location tracking or connectivity with weapons systems and other soldiers.

Dr Daniel Monti — CEO & Founding Director, Marcus Institute of Integrative Health — Jefferson Health

Exciting momentum!! — Home Depot Founder, Bernie Marcus (age 91), and the Adolph Coors Foundation (beer family), putting millions of $$$ into comprehensive integrative health and wellness — Good to see the trend!!

The Marcus Institute of Integrative Health was established in Philadelphia in 2017 by Thomas Jefferson University and Jefferson Health, and a multi-million $$$ grant from the Marcus Foundation (headed by it’s Chairman, Bernie Marcus, Co-Founder of The Home Depot) to expand the research, education and clinical care profile of Jefferson’s integrative medicine program, and to set the international standard of excellence in evidence-based, patient-centered integrative care.

The institute features a novel curriculum focusing on the clinical applications of integrative medicine with an emphasis on functional biochemistry, nutrient-based therapies, mind-body neuroscience, novel mechanisms of healing and emerging therapies.

Dr. Daniel Monti, MD, MBA is the Founding Director and Chief Executive Officer of the Marcus Institute of Integrative Health — Jefferson Health. He is also Professor and Founding Chair of the historic, first-ever Department of Integrative Medicine and Nutritional Sciences, Sidney Kimmel Medical College, Thomas Jefferson University.

Dr. Monti received his MD from The State University of New York at Buffalo School of Medicine. His Postdoctoral work was in the Research Scholars Program, Department of Psychiatry and Human Behavior, at Jefferson Medical College.

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Why are some scientists turning away from brain scans?

NEW YORK (AP) — Brain scans offer a tantalizing glimpse into the mind’s mysteries, promising an almost X-ray-like vision into how we feel pain, interpret faces and wiggle fingers.

Studies of brain images have suggested that Republicans and Democrats have visibly different thinking, that overweight adults have stronger responses to pictures of food and that it’s possible to predict a sober person’s likelihood of relapse.

But such buzzy findings are coming under growing scrutiny as scientists grapple with the fact that some brain scan research doesn’t seem to hold up.

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The Immortality Key — Brain Muraresku — The Secret History Of The Religion With No Name

Brain Muraresku, author of “The Immortality Key — The Secret History Of The Religion With No Name”, discussing his fascinating journey to discover psychedelic potions from antiquity, reconstruct their history in the development of religion and civilization, and their development into a modern neuro-pharmacopoeia.

On today’s show we are going to be weaving together a really interesting range of themes including psychedelics, pharmacognosy and medicinal botany, history, religion & spirituality, end of life care, dreaming, mental health and a whole lot more.

Brian Muraresku is the author of “The Immortality Key: The Secret History of the Religion with No Name”.

Brian graduated Phi Beta Kappa from Brown University with a degree in Latin, Greek and Sanskrit. As an alumnus of Georgetown Law and a member of the New York Bar, he has been practicing law internationally for fifteen years.

He is also founding executive director of Doctors for Cannabis Regulation. Their work has been featured on CNN and ESPN, as well as The Washington Post and San Francisco Chronicle. In arbitration with the NFL in 2018, Mr. Muraresku represented the first professional athlete in the United States to seek a therapeutic use exemption for cannabis.

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Drug Reverses Age-Related Mental Decline Within Days

Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study by UC San Francisco scientists. The drug, called ISRIB, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse cognitive impairments in Down Syndrome, prevent noise-related hearing loss, fight certain types of prostate cancer, and even enhance cognition in healthy animals.

In the new study, published Dec. 1, 2020, in the open-access journal eLife, researchers showed rapid restoration of youthful cognitive abilities in aged mice, accompanied by a rejuvenation of brain and immune cells that could help explain improvements in brain function.

“ISRIB’s extremely rapid effects show for the first time that a significant component of age-related cognitive losses may be caused by a kind of reversible physiological “blockage” rather than more permanent degradation,” said Susanna Rosi, PhD, Lewis and Ruth Cozen Chair II and professor in the departments of Neurological Surgery and of Physical Therapy and Rehabilitation Science.

INeuraLS — Advanced NeuroTech For Rapid Knowledge and Skill Acquisition — US AirForce Research Labs

Ineurals — advanced neuro-technologies for rapid learning and skill acquisition.

The 711th Human Performance Wing, under the U.S. Air Force Research Laboratory leads the development, integration, and delivery of Airman-centric research, education, and consultation enabling the U.S. Air Force to achieve responsive and effective global vigilance, global reach, and global power now and in the future. It’s comprised of the United States Air Force School of Aerospace Medicine and the Airman Systems Directorate, whose science and technology competencies include Training, Adaptive Warfighter Interfaces, Bioeffects, Bioengineering, and Aerospace and Operational Medicine.

The Individualized Neural Learning System, or iNeuraLS, is a new augmented learning platform that will enable rapid learning by closed-loop modulation of cognitive states during skill acquisition. Essentially, the AFRL team seeks to develop a capability that will give Airmen the ability to rapidly acquire knowledge and skills on the fly through direct brain interfaces with the help of neurotechnologies.

And we have not 1, but 2 fascinating guests on the show with us today:

Dr. Nathaniel Bridges serves as the Neural Interfaces Team Lead within the Air Force Research Laboratory’s Cognitive Neuroscience Section. In this role, he and his team seek to find and enable ways to link the human brain/nervous system with technology in a manner that will benefit the Air Force. This in part relies on testing and evaluating current and emerging Brain Machine/Computer Interface technologies for the Air Force and investigating the impact of various neuromodulation technologies on cognitive performance. Dr. Bridges has his PhD. in Biomedical Engineering, from Drexel University, in Philadelphia, PA USA.

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