Lifeboat Foundation

Machine enhanced humans — or cyborgs as they are known in science fiction — could be one step closer to becoming a reality, thanks to new research Lieber Group at Harvard University, as well as scientists from University of Surrey and Yonsei University.

Researchers have conquered the monumental task of manufacturing scalable nanoprobe arrays small enough to record the inner workings of human cardiac cells and primary neurons.

The ability to read electrical activities from cells is the foundation of many biomedical procedures, such as brain activity mapping and neural prosthetics. Developing new tools for intracellular electrophysiology (the electric current running within cells) that push the limits of what is physically possible (spatiotemporal resolution) while reducing invasiveness could provide a deeper understanding of electrogenic cells and their networks in tissues, as well as new directions for human-machine interfaces.

A South Indian philosopher sometimes called the “second Buddha,” Nagarjuna stands ambivalently at the beginnings of Mahayana philosophy. His arguments are subtle, sophisticated, and complex. Their interpretation is made more difficult because they are written as beautifully crafted quatrains whose density require extra concentration. As a transitional thinker, Nagarjuna is taken by some commentators (David Kalupahana and Jay Garfield) as continuing the Pali tradition and by others (Frederick Streng and T. Wood) as making a clean break with it. The latter school of interpretation reads Nagarjuna’s quatrains as thoroughly dialectical refutations of any positive thesis, even the minimalist claims of Pali realism. There is general consensus that the Yogacara school of Vasubandhu and Asanga reject Nagarjuna’s views, whatever they are, in favor of an objective idealism roughly similar to Hegel’s. Unfortunately, we do not have space to deal with Yogacara except only in an indirect way.

As we have seen, Pali Buddhists do not deny the appearance of an empirical self (jiva); rather, they deny that, corresponding to this appearance, there is anything enduring, separate, or independent. These may just be three different ways of saying the same thing, but since they represent three different types of Buddhist arguments, they merit separate presentations. First, there is no self that endures. What we see is constantly changing and there is nothing that stays the same. The traditional argument here proceeds by elimination: the physical bodies change; feelings, beliefs, desires, and intentions all change; consciousness is intermittent; and our self-conceptions change over time. None of the things we can point to as the self remains the same. Therefore the self does not endure. The argument is similar to the one given by Hume.

Second, the self is not separate from the causes and conditions that give rise to it. A standard metaphor for this comes from the Dhammapada, a Pali text from the 3rd century BCE. The appearance of a rainbow arises out of a certain combination of mist and light. Remove either one of these and the rainbow no longer exists. Similarly, the appearance of a self arises out of conditions: oxygen, food, parents, etc. Without them, there would be no self. This argument can be made on a general level, as just done, or on a particular level. You wouldn’t be the person you are if your family, friends, and acquaintances all weren’t the people they are, if you hadn’t had the experiences you’ve had, lived in the society you live in, etc. If we define the constellation of these conditions as one’s “world,” we can say that the self cannot be separated, either practically or logically, from the world in which it exists.

Current guidelines recommend lowering cholesterol for heart disease risk reduction. New findings indicate that if cholesterol dips too low, it may boost the risk of hemorrhagic stroke, according to researchers.

Over a period of nine years, a Penn State-led study examined the relationship between low-density lipoprotein cholesterol—LDL, commonly known as “bad” cholesterol—and hemorrhagic stroke. This type of stroke occurs when a blood vessel bursts in the brain.

The researchers found that participants with LDL cholesterol levels below 70 mg/dL had a higher risk of hemorrhagic stroke.

UNC School of Medicine scientists unveiled how a particular gene helps organize the scaffolding of brain cells called radial progenitors necessary for the orderly formation of the brain. Previous studies have shown that this gene is mutated in some people with autism.

Feature

In experiments on pig organs, scientists at Yale made a discovery that could someday challenge our understanding of what it means to die.

Credit credit thomas prior for the new york times.

Blood flows into the brain primarily via the carotid arteries and the vertebral arteries. The Circle of Willis is a circular arterial structure in the brain that connects blood flowing in from the carotid arteries with blood flowing in from the basilar artery (which is fed by the vertebral arteries). Blood flows from the Circle of Willis into brain tissue via the anterior, middle, and posterior cerebral arteries. Many studies have shown that the Circle of Willis is incomplete in most people. A 1998 study of 150 healthy adult volunteers showed a complete Circle of Willis in only 42% of cases — more often complete in younger persons and females [RADIOLOGY; Krabbe-Hartkamp, MJ; 207:103–111 (1998)]. A slightly more encouraging 2002 study of 118 healthy volunteers in the 65–68 age group, showed 47% had a complete Circle of Willis [THE JOURNAL OF CARDIOVASCULAR SURGERY; Macchi, C; 43:887–890 (2002)]

For cryonics purposes, it has been believed that perfusion into the carotid arteries, but not into the vertebral arteries will result in incomplete perfusion of the brain if the Circle of Willis is not complete. In particular, if both posterior communicating arteries are missing, then perfusing only through the carotid arteries will result in no blood getting to parts of the brain supplied by the posterior cerebral arteries. Both posterior communicating arteries were missing in 11% of those in the 1998 study and in 14% of those in the 2002 study cited above.

Nonetheless, a 2008 study showing Circle of Willis complete in only 40% of 99 patients found no case of insufficient perfusion in functional tests of patients given unilateral cerebral perfusion. The authors concluded that “extracranial collateral circulation” provides an alternative pathway to the Circle of Willis for cerebral crossperfusion [EUROPEAN JOURNAL OF CARDIOTHORACIC SURGERY; Urbanski, PP; 33:402–408 (2008)]. Although persons with missing posterior communicating arteries could easily have pathways to opposite sides of the brain, other variants of Circle of Willis incompleteness would be expected to prevent perfusion across hemispheres.

A new system called BrainNet lets three people play a Tetris-like game using a brain-to-brain interface.

This is the first demonstration of two things: a brain-to-brain network of more than two people, and a person being able to both receive and send information to others using only their brain.

“Humans are social beings who communicate with each other to cooperate and solve problems that none of us can solve on our own,” says corresponding author Rajesh Rao, a professor in the Paul G. Allen School of Computer Science & Engineering and a co-director of the Center for Neurotechnology at the University of Washington.

‘We essentially “trick’” the neurons in the back of the brain to spread around the message that they have received signals from the eyes,’ one researcher explains.

A new study reveals surprising variations in the neural code.

• By Ryan Dalton on July 2, 2019