Lifeboat Foundation

All human experience is rooted in the brain, but we just barely understand how it works. That’s partially because it’s hard to study: Scientists can’t just run experiments on living brains, and experiments on animal brains don’t always translate to humans. That’s why researchers developed the brain organoid, an artificially grown, three-dimensional cluster of human neurons that faithfully mimics brain development — and, as Japanese scientists reported Wednesday in Cell Stem Cell, the neural activity of a living brain as well.

Neurons in a living brain respond to stimuli by “firing” off electrical impulses, which they use to communicate with one another and with other parts of the body. The scientists behind the new paper discovered that the brain organoids they grew from scratch in their lab also started to exhibit synchronized activity, just like neurons in an actual brain. That team included first and co-corresponding author Hideya Sakaguchi, Ph.D., a postdoctoral fellow at Kyoto University currently at the Salk Institute.

“I was very excited to see some of the neurons activated at the same time robustly at first,” Sakaguchi, who did the first of his experiments in December 2016, tells Inverse. “Neurons first show individual activities, but as they form networks and connections between other neurons, they start to show synchronized activities.”

DMT, an active compound of the psychedelic Ayahuasca, is naturally occurring in the mammalian brain, researchers have discovered. The study revealed DMT levels increased significantly in the rat visual cortex following cardiac arrest.

Although the exact causes of multiple sclerosis still remain unknown, it is assumed that the disease is triggered by a combination of genetic and environmental risk factors. But which? In a mouse model of the disease, researchers at the University of Geneva (UNIGE) and the Geneva University Hospitals (HUG), Switzerland, studied the potential link between transient cerebral viral infections in early childhood and the development of this cerebral autoimmune disease later in life. Indeed, the brain area affected by viral infection during childhood undergoes a change that can call, a long time later, on the immune system to turn against itself at this precise location, triggering autoimmune lesions. These results, which are published in the journal Science Translational Medicine, provide a first step in answering one of the possible environmental causes of this serious disease.

Multiple sclerosis affects one in 1,000 people in Switzerland, two-thirds of whom are women. It is the most common auto-immune disease affecting the brain. Up to date, there is still neither a cure available, nor a clear understanding of the factors that trigger this disease at around 30 years of age. “We asked ourselves whether brain viral infections that could be contracted in early childhood were among the possible causes,” says Doron Merkler, a professor in the Department of Pathology and Immunology in UNIGE’s Faculty of Medicine and senior consultant in the Clinical Pathology Service of the HUG. Such transient brain infections can be controlled quickly by the immune system, without the affected individual even noticing any symptoms. “But these transient infections may, under certain circumstances, leave a local footprint, an inflammatory signature, in the brain,” continues the researcher.

Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology.

More than 80 million men, women and children in the United States experience hair loss. Genetics, aging, childbirth, cancer treatment, burn injuries and medical disorders such as alopecia can cause the condition. Hair loss is often associated with emotional distress that can reduce quality of life and lead to anxiety and depression.

“Our new protocol described today overcomes key technological challenges that kept our discovery from real-world use,” says Alexey Terskikh, Ph.D., an associate professor in Sanford Burnham Prebys’ Development, Aging and Regeneration Program and the co-founder and chief scientific officer of Stemson Therapeutics. “Now we have a robust, highly controlled method for generating natural-looking hair that grows through the skin using an unlimited source of human iPSC-derived dermal papilla cells. This is a critical breakthrough in the development of cell-based hair-loss therapies and the regenerative medicine field.”

An all-star panel of experts in nutritional studies with an emphasis on longevity. At some point in your life, you have heard the following. “Eat the right food. It will help you live longer.” What if I told you the right food could help you heal as well. This panel of longevity driven nutritionist will give you a broad range of fact-based regiments and compelling individual opinions on Nutrition and longevity.
This segment will cover many diverse understandable methods that can make a change in longevity for you or your loved ones. Fill yourself with the knowledge of proper nutrition for longevity.

Speakers Will Include:
Brian Clement – Plant-Based & founder of “Hippocrates Health Institute”
A typical American growing up in the New Jersey/New York area, Brian likes to joke that he was a pioneer in the field of obesity—he was fat even before many Americans were fat! Raised in an Irish household on the standard American diet of meat, processed foods, and sugary sodas, he was unfit and gasping for air every few steps. When he was 20 years old, he was dating a girl whose best friend’s boyfriend was 30—and a vegetarian. Despite the fact he had been more or less educated by his family that the body would die without animal-based foods, the lure of an influential peer inspired him to give up meat in one fell swoop. For the first year and a half, he kept his vegetarian diet a secret from his family. Yet after losing 120 pounds and experiencing the difference in his health, he came out of the proverbial closet (much to his family’s dismay!) and became a complete vegan three years later.

Continue reading “Nutrition for Longevity” »

There are certain enzymes — proteins — plaques that help cause Alzheimer’s, just recently in fact {which I as most could have told them} the gut microbes and mouth microbes are found to assist in Dementia and Alzheimers. But I and Hippocrates as others have been declaring that fact for quite some time… Respect AEWR wherein the amazing gathered data of mankind has yielded the many causes and a cure for aging…

For decades, research into Alzheimer’s has made slow progress, but now a mother and daughter team think they have finally found a solution – a vaccine that could inoculate potential sufferers.

Genetic Brain-Mapping of Autism.

The Brain Initiative is combining neuroscience with nanotechnology in the world’s biggest project to understand the mind. By Katharine Sanderson.

Sydney — Post-mortem examinations have found a degenerative brain disease linked to repeated blows to the head in two elite Australian rugby league players, the first cases found in the sport, researchers said on Thursday.

The researchers said the players both had chronic traumatic encephalopathy (CTE), which has been widely diagnosed among former US National Football League (NFL) players but is little studied elsewhere.

The Sydney-based study said the condition, once known as ‘punch drunk syndrome’ occurred when repeated brain trauma led to a long-term decline in cognitive function.

Nano Lett. 2017 Sep 13;17:5836–5842. doi: 10.1021/acs.nanolett.7b03081. Epub 2017 Aug 14.

Syringe-injectable mesh electronics represent a new paradigm for brain science and neural prosthetics by virtue of the stable seamless integration of the electronics with neural tissues, a consequence of the macroporous mesh electronics structure with all size features similar to or less than individual neurons and tissue-like flexibility. These same properties, however, make input/output (I/O) connection to measurement electronics challenging, and work to-date has required methods that could be difficult to implement by the life sciences community. Here we present a new syringe-injectable mesh electronics design with plug-and-play I/O interfacing that is rapid, scalable, and user-friendly to nonexperts. The basic design tapers the ultraflexible mesh electronics to a narrow stem that routes all of the device/electrode interconnects to I/O pads that are inserted into a standard zero insertion force (ZIF) connector.