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Category: neuroscience – Page 503

Feasibility of mapping the human brain with expansion x-ray microscopy

Hey folks, I’m excited to share a new essay with y’all on my proposed route towards nanoscale human brain connectomics. I suggest that synchrotron ‘expansion x-ray microscopy’ has the potential to enable anatomical imaging of the entire human brain with sub-100 nm voxel size and high contrast in around 1 year for a price of roughly $10M. I plan to continue improving this essay over time as I acquire more detailed information and perform more calculations.

For a brief history of this concept: I started exploring this idea during undergrad (working with a laboratory-scale x-ray microscope), but was cut short by the pandemic. Now, I’m working on a PhD in biomedical engineering centered on gene therapy and synthetic biology, but I have retained a strong interest in connectomics. I recently began communication with some excellent collaborators who might be able to help move this technology forward. Hoping for some exciting progress!

By Logan Thrasher Collins.

PDF version

Can I Prevent Dementia?

Step one for uploading your brain after the singularity… keep it cognitively functional until then.

It’s been estimated that one in three cases of dementia is preventable. You can’t do anything right now to stop or reverse the underlying mechanisms of Alzheimer’s disease, but you can do something about hypertension and vascular disease risk factors.

#dementia #alzheimer #doctor #healthylifestyle #health #intermittentfasting

Mystical and Insightful Psychedelic Experience May Improve Mental Health

Summary: Recent studies have explored the use of psychedelics for the treatment of a range of mental health disorders. A new study reveals more insightful and mystical “trips” while exposed to psychedelics may be linked to an enduring reduction of symptoms for those with anxiety and depression.

Source: Ohio State University.

A more mystical and insightful psychedelic drug experience may be linked to an enduring reduction in anxiety and depression symptoms, according to a new study.

Ben Goertzel — Countering Objections to Mind Uploading

Ben Goertzel in response to some common objections covered in an article on io9 by George Dvorsky ‘You’ll Probably Never Upload Your Mind Into A Computer’: http://io9.com/you-ll-probably-never-upload-your-mind-into-a-computer-474941498

Objections are covered in order as they appear in the article:
1. Brain functions are not computable.
2. We’ll never solve the hard problem of consciousness.
3. We’ll never solve the binding problem.
4. Panpsychism is true.
5. Mind-body dualism is true.
6. It would be unethical to develop.
7. We can never be sure it works.
8. Uploaded minds would be vulnerable to hacking and abuse.

Ben Goertzel wrote a response to the io9 article: http://hplusmagazine.com/2013/04/20/goertzel-contra-dvorsky-on-mind-uploading/

http://www.goertzel.org.

http://opencog.org.

Scientists grow electrodes in brain, thanks to a simple viscous gel

Blurring lines between man and machine.

A breakthrough has made way for a new paradigm in bioelectronics. Earlier, it took the implantation of physical objects to initiate electronic processes in the body. Humans have incorporated technology to enhance the human experience and take charge of their evolution. They’ve also integrated devices within them that could alternately function as organs when biological tissues fail.

Scientists have now developed a viscous gel that will be enough in the future.

Researchers at Linköping, Lund, and Gothenburg universities in Sweden have successfully grown electrodes in living tissue using the body’s molecules as triggers.

Thor Balkhed.

Earlier, it took the implantation of physical objects to initiate electronic processes in the body. Humans have incorporated technology to enhance the human experience and take charge of their evolution. They’ve also integrated devices within them that could alternately function as organs when biological tissues fail.

Continue reading “Scientists grow electrodes in brain, thanks to a simple viscous gel” | >

Martin Ciupa — Bing, ChatGPT & Artificial Intelligence

Microsoft’s ChatGPT-powered Bing search engine is sending “unhinged” messages to users, telling lies, sulking, gaslighting, questioning why it exists, and more. Martin Ciupa discusses ChatGPT, large language models, and artificial intelligence research.

Martin Ciupa is a subject matter expert on artificial intelligence, communications and information technology. Martin is the CEO of Remoscope Inc, an AI-based Telehealth startup, and an advisor & consultant to Mindmaze, a Unicorn Neurotech company focuses on applying advanced neuroscience to everyday life.

Martin has decades of experience in computing and artificial intelligence, PhD studies in AI, and a Master’s Degree in Cybernetics.

The mind-bending physics of time | Sean Carroll

How the Big Bang gave us time, explained by theoretical physicist Sean Carroll.

Up next, The Universe in 90 minutes: Time, free will, God, & more ► https://youtu.be/tM4sLmt1Ui8

In this Big Think interview, theoretical physicist Sean Carroll discusses the concept of time and the mysteries surrounding its properties. He notes that while we use the word “time” frequently in everyday language, the real puzzles arise when we consider the properties of time, such as the past, present, and future, and the fact that we can affect the future but not the past.

Carroll also discusses the concept of entropy, which is a measure of how disorganized or random a system is, and the second law of thermodynamics, which states that there is a natural tendency for things in the universe to go from a state of low entropy to high entropy. He explains that the arrow of time, or the perceived difference between the past and the future, arises due to the influence of the Big Bang and the fact that the universe began in a state of low entropy.

Carroll also touches on the possibility of time travel and the concept of the multiverse.

Read the video transcript ► https://bigthink.com/series/explain-it-like-im-smart/the-Big-Bang-gave-us-time.

Continue reading “The mind-bending physics of time | Sean Carroll” | >

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

In a recent study published in Cell, researchers presented eight hallmarks of neurodegenerative diseases (NDDs), their in vivo biomarkers, and interactions to help categorize NDDs and specify patients within a specific NDD.

Despite being linked to rare genetic forms, all eight NDD hallmarks (cellular/molecular processes) also contribute to sporadic NDDs. In addition, they contribute to neuronal loss in preclinical (animal) models and NDD patients, manifesting as an altered molecular (hallmark) biomarker.

An NDD patient could have defects in multiple NDD hallmarks. However, the primary NDD hallmark depends on the NDD insult and the neuronal susceptibility and resilience, i.e., one’s ability to handle insults in the affected brain region.