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Getting Closer To Understanding Consciousness ⚡️

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In this Lightning Round video, we consider the difference between consciousness and sentience, I talk about the planet I’d want to visit, and what’s the deal with pheromones?

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‘Brain dead’ man trapped in body heard debate about turning off his life support

In 2017, Jacob Haendel was living a normal life as a head chef in…


A paralysed man who had an extreme form of locked-in syndrome and heard a nurse say he was “brain dead” has become the first ever to recover after hearing medical professionals debating whether or not to switch off his life support.

In 2017, Jacob Haendel was living a normal life as a head chef in Boston, Massachusetts but in the space of a few weeks, his life was turned upside down after he was diagnosed with acute toxic progressive leukoencephalopathy, which progressed into locked-in syndrome and forced his body would slowly shut down. An extreme form of locked-in syndrome is a condition where a patient is aware but cannot move or communicate verbally due to complete paralysis and can be caused by brain trauma, infection or exposure to toxins.

It is not known exactly how Jacob developed the condition, though he says his life as a chef consuming certain chemicals “wilfully and otherwise” may have been a factor. He ended up paralysed, unable to talk or blink within a few months and, could hear hospital staff deliberating over switching off machines.

Dysfunction of neurons in the amygdala may be behind negative perceptions of the environment

One of the characteristics of depression is a tendency to perceive sensory stimuli and everyday situations in an excessively negative way. But the mechanisms underpinning this “negativity bias,” which can fuel the development of depressive symptoms, had previously remained largely unknown.

Neuroscience sheds light on brain mechanisms underlying exceptional creativity

A new study sheds light on how highly creative individuals, such as visual artists and scientists, may have brains that function differently compared to others. The research, published in Psychology of Aesthetics, Creativity, and the Arts, reveals that people who exhibit exceptional creativity—referred to as “Big C” creative individuals—demonstrate…

Lengthening Telomeres To Rewind the Clock of Aging

Haven’t heard from Bill Andrews in awhile.


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Here we talk with Dr Bill Andrews all about telomeres, why they are on the critical path of aging and finding a way to lengthen them is required in an complete longevity solution.
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⏲️Chapters.
00:00 Why telomeres.
07:10 Telomeres and aging.
14:36 Telomerase in stem cells.
20:15 BiOptimizers.
21:44 Telomere shortening.
23:25 Measuring telomere length.
25:30 Biological age.
30:30 Slowing telomere shortening.
39:30 Supplements to help.
41:30 Sierra Science Chemicals \& Gene therapy.
49:30 How is telomerase repressed.
56:10 Liz Parrish \& Gene therapy.
1:01:40 Gene therapy delivery.
1:09:20 Telomerase \& cancer.
1:17:00 Why aging.
1:20:30 Telomeres \& senescence.
1:24:30 More information.

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Mental Fatigue Triggers Compensatory Brain Mechanisms

New research reveals that prolonged mental load weakens brain connectivity, but compensatory mechanisms keep cognitive performance steady.


Summary: A recent study shows that prolonged mental exertion weakens connectivity between the brain’s frontal and parietal lobes, impacting cognitive efficiency. However, the brain has built-in compensatory mechanisms that adjust neural connections to preserve function under fatigue.

Researchers observed this in participants completing memory tasks of varying difficulty; while fatigue slowed performance on simple tasks, complex tasks triggered compensatory adjustments. Findings suggest that these mechanisms allow the brain to optimize resources based on task complexity.

Understanding how these processes work can have implications for enhancing productivity and mental resilience in high-demand scenarios. This research highlights the brain’s adaptability in managing limited cognitive resources under strain.

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