In part one of this two-part podcast, HDIAC analyst Mara Kiernan interviews Dr. James Giordano, a Professor in the department of Neurology and Biochemistry at Georgetown University Medical Center. The discussion begins with Dr. Giordano defining neuroweapons and explaining their applied technologies. He provides insight into the manner in which international weapons conventions govern the use neuroweapons and discusses the threats presented by neuroweapons in today’s environment. Dr. Giordano goes on to review the need for continuous monitoring, including his views regarding challenges and potential solutions for effectively understanding global developments in neuroweapon technologies.
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What is the mechanism that allows our brains to incorporate new information about the world, and form memories? New work by a team of neuroscientists led by Dr Tomás Ryan from Trinity College Dublin shows that learning occurs through the continuous formation of new connectivity patterns between specific engram cells in different regions of the brain.
Whether on purpose, incidentally, or simply by accident, we are constantly learning and so our brains are constantly changing. When we navigate the world, interact with each other, or consume media content, our brain is grasping information, creating new memories.
The next time we walk down the street, meet our friends, or come across something that reminds us of the last podcast we listened to, we will quickly re-engage that memory information somewhere in our brain. But how do these experiences modify our neurons to allow us to form these new memories?
The Four Realms of Existence by Joseph LeDoux and Consciousness by John Parrington tell us a lot about human cognition, brain structure and evolution – but most of all they demonstrate how far this most tricky of quests still has to go.
This paper characterizes two distinct philosophies underlying previous work on how Bayesian computations are linked to neural data, highlighting how different theories may be motivated by different tacit assumptions and thereby explain different data.
Go to https://buyraycon.com/isaacarthur to get 20 to 50% off sitewide! Brought to you by Raycon. In the grand theater of the cosmos, amidst a myriad of distant suns and ancient galaxies, the Fermi Paradox presents a haunting silence, where a cacophony of alien conversations should exist. Where is Everyone? Or are we alone?
Credits: The Fermi Paradox Compendium of Solutions & Terms. Episode 420; November 9, 2023 Written, Produced & Narrated by: Isaac Arthur. Editors: Donagh Broderick.
Graphics by: Darth Biomech. Jeremy Jozwik. Katie Byrne. Ken York YD Visual. Legiontech Studios. Sergio Botero. Tactical Blob. Udo Schroeter.
Music Courtesy of: Epidemic Sound http://epidemicsound.com/creator. Markus Junnikkala, “Memory of Earth“ Stellardrone, “Red Giant”, “Ultra Deep Field“ Sergey Cheremisinov, “Labyrinth”, “Forgotten Stars“ Miguel Johnson, “The Explorers”, “Strange New World“ Aerium, “Fifth star of Aldebaran”, “Windmill Forests”, “Deiljocht“ Lombus, “Cosmic Soup“ Taras Harkavyi, “Alpha and…”
Is the Matrix really real? And if so, which pill would David Chalmers take?
Join us for a mind-bending journey through virtual worlds, human consciousness, technology, philosophy, and religion, and find out!
David Chalmers is an Australian philosopher and cognitive scientist specializing in the areas of philosophy of mind and philosophy of language. He is a Professor of Philosophy and Neural Science at New York University and co-director of NYU’s Center for Mind, Brain, and Consciousness (along with Ned Block).
Neuralink, the Elon Musk-founded company developing implantable chips that can read brain waves, has raised an additional $43 million in venture capital, according to a filing with the SEC.
The filing published this week shows the company increased its previous tranche, led by Peter Thiel’s Founders Fund, from $280 million to $323 million in early August. Thirty-two investors participated, according to the filing.
Neuralink hasn’t disclosed its valuation recently. But in June, Reuters reported that the company was valued at about $5 billion after privately-executed stock trades.
The Unique Cytoarchitecture and Wiring of The Default Mode Network. Casey Paquola.
Background. Complex behaviours benefit from parallel distributed processing in multiple brain networks. The roles of certain networks are well-defined, while others remain elusive. Arguably, none are so elusive as the default mode network (DMN); a distributed set of brain regions that decrease in activity during many externally oriented tasks. Revealing the cytoarchitectural composition and connectional layout of the DMN is crucial to defining its role in complex behaviours.
Method. We examined the cytoarchitectural composition of the DMN using an established cortical type atlas (García-Cabezas et al., 2020; Von Economo and Koskinas, 1925) and by applying non-linear dimensionality reduction to BigBrain-derived staining intensity profiles (Paquola et al., 2019). Next, we used magnetic resonance imaging (MRI) to explicate structural wiring and effective connectivity of the whole brain. In both modalities, we examined the influence of cytoarchitecture on extrinsic connectivity of the DMN. Finally, we evaluated the uniqueness of the DMN relative to other large-scale functional brain networks.
Results. We discovered profound diversity of DMN cytoarchitecture. Each circumscribed subregion of the DMN contains a broad range of cytoarchitectural types, however, the spatial pattern within each subregion differs. The patterns vary in smoothness from a gradient in the parahippocampus to interdigitation in the superior frontal gyrus. We found that cytoarchitectural differentiation in the DMN aligns with its structural wiring and extrinsic information flow. The structural heterogeneity of the DMN engenders a network-level balance in communication with external and internal sources, which is distinctive, relative to other functional networks. Conclusion. These findings suggest a novel wiring diagram of structural and functional connectivity of the DMN that is compatible with its putative role in balancing internal and external information. Furthermore, our work demonstrates the import of neuroanatomical evidence in specifying theories of functional networks.
An amazing graph theoretic analysis of the C. elegans neuropeptide connectome!
Neuromodulation by peptides is essential for brain function. By comprehensively mapping neuropeptide signaling in the nematode C. elegans, Ripoll-Sánchez et al. define a dense wireless network whose organization differs in important ways from wired brain circuits. This network is a prototype for understanding neuropeptide signaling networks in larger brains.
