Lifeboat Foundation

Misfolded proteins are toxic to cells. They disrupt normal functions and cause some age-related human degenerative diseases, like Alzheimer’s, Parkinson’s, and Huntington’s diseases. Cells work constantly to eliminate misfolded proteins, but these clearance mechanisms are still poorly understood.

In a new study published April 20 in Nature Cell Biology, researchers at Stanford University discovered a previously unknown cellular pathway for clearing misfolded proteins from the nucleus, the compartment where the cell stores, transcribes, and replicates its DNA. Keeping junk away from those processes is critical to normal cellular function. The new pathway could be a target for age-related disease therapies.

To find the new pathway, researchers in the lab of Judith Frydman, the Donald Kennedy Chair in the School of Humanities and Sciences, integrated several genetic, imaging, and biochemical approaches to understand how yeast cells dealt with misfolded proteins. For the experiments, the team restricted misfolded proteins to either the nucleus or the cytoplasm—the area inside the cell but outside the nucleus. The team visually followed the fate of the misfolded proteins through live-cell imaging and super-resolution microscopy.

An international team led by scientists at the University of Sydney has demonstrated nanowire networks can exhibit both short-and long-term memory like the human brain.

The research has been published today in the journal Science Advances (“Neuromorphic learning, working memory, and metaplasticity in nanowire networks”), led by Dr Alon Loeffler, who received his PhD in the School of Physics, with collaborators in Japan.

Photograph of nanowire network (left), network’s pathways changing and strengthening (right). (Image: Alon Loeffler)

Aging clocks estimate how fast specific organs are deteriorating—but it’s hard to know what to do with the results.

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If I have a visual experience that I describe as a red tomato a meter away, then I am inclined to believe that there is, in fact, a red tomato a meter away, even if I close my eyes. I believe that my perceptions are, in the normal case, veridical—that they accurately depict aspects of the real world. But is my belief supported by our best science? In particular: Does evolution by natural selection favor veridical perceptions? Many scientists and philosophers claim that it does. But this claim, though plausible, has not been properly tested. In this talk, I present a new theorem: Veridical perceptions are never more fit than non-veridical perceptions which are simply tuned to the relevant fitness functions. This entails that perception is not a window on reality; it is more like a desktop interface on your laptop. I discuss this interface theory of perception and its implications for one of the most puzzling unsolved problems in science: the relationship between brain activity and conscious experiences.

Continue reading “Is Reality an Illusion? — Professor Donald Hoffman, PhD” »

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It’s a step that could one day lead to advances for humans that boost quality of life for many by: giving amputees and those with spinal injuries control of advanced prosthetics, stimulating the sacral nerve to restore bladder control, stimulating the cervical vagus nerve to treat epilepsy and providing deep brain stimulation as a possible treatment for Parkinson’s.

How far would you go to keep your mind from failing? Would you go so far as to let a doctor drill a hole in your skull and stick a microchip in your brain?

It’s not an idle question. In recent years neuroscientists have made major advances in cracking the code of memory, figuring out exactly how the human brain stores information and learning to reverse-engineer the process. Now they’ve reached the stage where they’re starting to put all of that theory into practice.

Last month two research teams reported success at using electrical signals, carried into the brain via implanted wires, to boost memory in small groups of test patients. “It’s a major milestone in demonstrating the ability to restore memory function in humans,” says Dr. Robert Hampson, a neuroscientist at Wake Forest School of Medicine and the leader of one of the teams.

As fun as brain-computer interfaces (BCI) are, for the best results they tend to come with the major asterisk of requiring the cutting and lifting of a section of the skull in order to implant a Utah array or similar electrode system. A non-invasive alternative consists out of electrodes which are placed on the skin, yet at a reduced resolution. These electrodes are the subject of a recent experiment by [Shaikh Nayeem Faisal] and colleagues in ACS Applied NanoMaterials employing graphene-coated electrodes in an attempt to optimize their performance.

Although external electrodes can be acceptable for basic tasks, such as registering a response to a specific (visual) impulse or for EEG recordings, they can be impractical in general use. Much of this is due to the disadvantages of the ‘wet’ and ‘dry’ varieties, which as the name suggests involve an electrically conductive gel with the former.

This gel ensures solid contact and a resistance of no more than 5 – 30 kΩ at 50 Hz, whereas dry sensors perform rather poorly at 200 kΩ at 50 Hz with worse signal-to-noise characteristics, even before adding in issues such as using the sensor on a hairy scalp, as tends to be the case for most human subjects.

Neuralace™ is a glimpse of what’s possible in the future of BCI.

This patent pending concept technology is the start of Blackrock’s journey toward whole-brain data capture–with transformative potential for the way neurological disorders are treated. With over 10,000 channels and a flexible lace structure that seamlessly conforms to the brain, Neuralace has potential applications in vision and memory restoration, performance prediction, and the treatment of mental health disorders like depression.

Continue reading “Neuralace™ | The next-generation of BCI and whole-brain data capture” »

Blackrock’s long-tested NeuroPort® Array, widely considered the gold standard of high-channel neural interfacing, has been used in human BCIs since 2004 and powered many of the field’s most significant milestones. In clinical trials, patients using Blackrock’s BCI have regained tactile function, movement of their own limbs and prosthetics, and the ability to control digital devices, despite diagnoses of paralysis and other neurological disorders.

While Blackrock’s BCI enables patients to execute sophisticated functions without reliance on assistive technologies, next-generation BCIs for areas such as vision and memory restoration, performance prediction, and treatment of mental health disorders like depression will need to interface with more neurons.

Neuralace is designed to capitalize on this need; with 10,000+ channels and the entire scalable system integrated on an extremely flexible lace-structured chip, it could capture data that is orders of magnitude greater than existing electrodes, allowing for an exponential increase in capability and intuitiveness.