NIA-funded researchers identified areas of the genome responsible for accelerating or slowing down brain aging.
In a new medical breakthrough, scientists have successfully grown a synthetic embryo of a mouse without male sperm and a female womb. They used stem cells from mice to recreate the first stage of life and successfully developed an embryo with a brain, beating heart, and vitals for other organs.
The natural process of life was mimicked in the lab without eggs or sperm but with the body’s master cells, which can develop into almost any cell type in the body. The embryo was developed 8 ½ days after fertilization, containing the same structures as a natural one.
The study published in the journal Nature states that their result demonstrates the self-organization ability of embryonic and two types of extra-embryonic stem cells to reconstitute mammalian development. The researchers induced expression of a particular set of genes and established a unique environment for their interactions and got the stem cells to ‘talk’ to each other.
Meta CEO Mark Zuckerberg outlined the company’s approach to neural interface technology — tech which lets you control technology with your mind — in an interview on podcast The Joe Rogan Experience.
Zuckerberg said Meta is researching neural interface tech as part of its push into the metaverse.
He said the company is primarily focused on tech which can receive signals from the brain but does send any information back to it.
“If cells are dreaming, [these images] are what the cells are dreaming about,” neuroscientist Carlos Ponce told The Atlantic. “It exposes the visual vocabulary of the brain, in a way that’s unbiased by our anthropomorphic perspective.”
Some neurons responded to images that vaguely resembled objects that the scientists recognized, suggesting that the researchers identified the specific neurons that corresponded with particular real-world objects. A blur that resembled a monkey’s face accompanied by a red blotch may have corresponded to another monkey in the lab that wore a red collar. Another blur that resembled a human wearing a surgical mask may have represented the woman who took care of and fed the lab’s monkeys, who wore a similar mask.
Other images that the monkey neurons responded to the most were less realistic, instead taking the form of various streaks and splotches of color, according to The Atlantic.
Just yesterday (2022−08−24) Prof. Smolin had a deep brain stimulator inserted into his left Globus Pallidus to help him better manage his symptoms of Parkinson’s Disease. Here he talks about that day, his theory of PD and the journey he had been on to getting DBS.
Eavesdropping on the earliest conversations between tissues in an emerging life could tell us a lot about organ growth, fertility, and disease in general. It could help prevent early miscarriages, or even tell us how to grow whole replacement organs from scratch.
In a monumental leap in stem cell research, an experiment led by researchers from the University of Cambridge in the UK has developed a living model of a mouse embryo complete with fluttering heart tissues and the beginnings of a brain.
The research advances the recent success of a team comprised of some of the same scientists who pushed the limits on mimicking the embryonic development of mice using stem cells that had never seen the inside of a mouse womb.
Even during such routine tasks as a daily stroll, our brain sometimes needs to shift gears, switching from navigating the city to jumping out of the way of a bike or to crossing the street to greet a friend. These switches pose a challenge: How do the brain’s circuits deal with such dynamic and abrupt changes in behavior? A Weizmann Institute of Science study on bats, published today in Nature, suggests an answer that does not fit the classical thinking about brain function.
“Most brain research projects focus on one type of behavior at a time, so little is known about the way the brain handles dynamically changing behavioral needs,” says Prof. Nachum Ulanovsky of Weizmann’s Brain Sciences Department. In the new study, he and his team designed an experimental setup that mimicked real-life situations in which animals or humans rapidly switch from one behavior to another—for example, from navigation to avoiding a predator or a car crash. Graduate students Dr. Ayelet Sarel, Shaked Palgi and Dan Blum led the study, in collaboration with postdoctoral fellow Dr. Johnatan Aljadeff. The study was supervised by Ulanovsky together with Associate Staff Scientist Dr. Liora Las.
Using miniature wireless recording devices, the researchers monitored neurons in the brains of pairs of bats that had to avoid colliding with one another while flying toward each other along a 135-meter-long tunnel at the high speed of 7 meters per second. This amounted to a relative speed—that is, the rate at which the distance between the bats closed, or the sum of both bats’ speeds—of 14 meters per second, or about 50 kilometers an hour.
During mammalian brain development, neural precursor cells first generate neurons and later astrocytes. This cell fate change is a key process generating proper numbers of neurons and astrocytes. Here we discovered that FGF regulates the cell fate switch from neurons to astrocytes in the developing cerebral cortex using mice. FGF is a critical extracellular regulator of the cell fate switch, necessary and sufficient, in the mammalian cerebral cortex.
Neurons and astrocytes are prominent cell types in the cerebral cortex. Neurons are the primary information processing cells in the brain, whereas astrocytes support and modulate their functions. For sound functioning of the brain, it is crucial that proper numbers of neurons and astrocytes are generated during fetal brain development. The brain could not function correctly if only neurons or astrocytes were generated.
During fetal brain development, both neurons and astrocytes are generated from neural stem cells, which give rise to almost all cells in the cerebral cortex (Figure 1). One of the characteristics of this developmental process is that neural stem cells first generate neurons and, after that, start generating astrocytes (Figure 1). The “switch” to change the cell differentiation fate of neural stem cells from neurons to astrocytes has attracted much attention, since the cell fate switch is key to the generation of proper numbers of neurons and astrocytes. However, it remained largely unknown.
Researchers at Sahlgrenska Academy at the University of Gothenburg, Sweden, in collaboration with research groups in Finland, Canada and Slovenia, have discovered a novel and unexpected function of nestin, the best-known marker of neural stem cells.
In the developing brain, the three main cell types, neurons, astrocytes and oligodendrocytes, are generated from neural stem cells. In some parts of the brain such as the hippocampus, the brain region involved in learning and memory, new neurons are being added to the existing neuronal circuitry even in adulthood, when severe restriction of neuronal differentiation occurs.
Using mice deficient in nestin, a protein that is a component of the part of the cytoskeleton known as intermediate filaments or nanofilaments, the research team led by Prof. Milos Pekny showed that nestin produced in astrocytes has an important role in inhibiting neuronal differentiation. They linked this regulatory function of nestin to the Notch signaling from astrocytes to neighboring neural stem cells. Thus, surprisingly, nestin does not control the generation of neurons by acting within neural stem cells, but indirectly by regulating the neurogenesis-inhibitory Notch signals that neural stem cells receive from astrocytes, important constituents of the neurogenic niche.
