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Category: neuroscience – Page 259

It wouldn’t shock me if all the buzz around searching for the ‘locus of consciousness’ merely fine-tunes our grasp of how the brain is linked to consciousness — without actually revealing where consciousness comes from, because it’s not generated in the brain. Similarly, your smartphone doesn’t create the Internet or a cellular network; it just processes them. Networks of minds are a common occurrence throughout the natural world. What sets humans apart is the impending advent of cybernetic connectivity explosion that could soon evolve into a form of synthetic telepathy, eventually leading to the rise of a unified, global consciousness — what could be termed the Syntellect Emergence.

#consciousness #phenomenology #cybernetics #cognition #neuroscience

In summary, the study of consciousness could be conceptualized through a variety of lenses: as a series of digital perceptual snapshots, as a cybernetic system with its feedback processes, as a grand theater; or perhaps even as a VIP section in a cosmological establishment of magnificent complexity. Today’s leading theories of consciousness are largely complementary, not mutually exclusive. These multiple perspectives not only contribute to philosophical discourse but also herald the dawn of new exploratory avenues, equally enthralling and challenging, in our understanding of consciousness.

In The Cybernetic Theory of Mind (2022), I expand on existing theories to propose certain conceptual models and concepts, such as Noocentrism, Digital Presentism (D-Theory of Time), Experiential Realism, Ontological Holism, Multi-Ego Pantheistic Solipsism, the Omega Singularity, deeming a non-local consciousness, or Universal Mind, as the substrate of objective reality. In search of God’s equation, we finally look upward for the source. What many religions call “God” is clearly an interdimensional being within the nested levels of complexity. Besides setting initial conditions for our universe, God speaks to us in the language of religion, spirituality, synchronicities and transcendental experiences.

Continue reading “What Constitutes Your Stream of Consciousness?” | >

Summary: Neuroscientists delved into the mechanisms behind true and false memories. Their study reveals that electrical signals in the hippocampus can differentiate between the imminent recall of authentic versus fabricated memories.

By monitoring neural activity in epilepsy patients, the team identified distinct patterns ahead of a correct or false recall. These findings not only offer insights into memory retrieval but may also pave the way for novel therapeutic interventions for disorders like PTSD.

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The question comes down to this: If materialism collapses, what will science look like? Will the people who are interested in science today continue to be so? Will the same people continue to dominate?

One thing for sure: A lot of things will come tumbling out in the wash.

*In my experience, the abortion issue has mostly been Catholic and other grannies vs. abortionists. If, like David Chalmers, you are inclined to take bets, bet on the grannies.

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The human brain can change – but usually only slowly and with great effort, such as when learning a new sport or foreign language, or recovering from a stroke. Learning new skills correlates with changes in the brain, as evidenced by neuroscience research with animals and functional brain scans in people. Presumably, if you master Calculus 1, something is now different in your brain. Furthermore, motor neurons in the brain expand and contract depending on how often they are exercised – a neuronal reflection of “use it or lose it.”

People may wish their brains could change faster – not just when learning new skills, but also when overcoming problems like anxiety, depression and addictions.

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Change in the brain usually comes with plenty of effort over time. Neuroscientists are working to understand how psychedelic drugs provide a shortcut that seems to rely on existing brain systems.

Continue reading “Psychedelics plus psychotherapy can trigger rapid changes in the brain − new research at the level of neurons is untangling how” | >

Participants individually interacted with a conversational AI mental health chatbot for about 30 minutes to determine if they would recommend it to a friend.

As human beings, we rely on recommendations or warnings from our friends and family. It gives us an added perspective on what to expect from a particular service, a product, or another human being. As per the latest study, the same is true for the way in which we trust and perceive an AI chatbot.

Researchers from Massachusetts Institute of Technology (MIT) and Arizona State University conducted a study in which they found that even though every person in their sample size of 310 people interacted with the exact same chatbot, their interactions with it were influenced by what they had been told before.

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“New devices can read and manipulate our mental states to help us relax, learn and reduce pain. As they do this, they harvest data. Can businesses be trusted with this private information? How can we make use of this technology while protecting the last fortress of our humanity — our thoughts and emotions?”

As neurotechnology becomes widely accessible, do we need to legally protect our thoughts?

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A typical vaccine teaches the human immune system to recognize a virus or bacteria as an enemy that should be attacked. The new “inverse vaccine” does just the opposite: it removes the immune system’s memory of one molecule. While such immune memory erasure would be unwanted for infectious diseases, it can stop autoimmune reactions like those seen in multiple sclerosis, type I diabetes, or rheumatoid arthritis, in which the immune system attacks a person’s healthy tissues.

The inverse vaccine, described in Nature Biomedical Engineering, takes advantage of how the liver naturally marks molecules from broken-down cells with “do not attack” flags to prevent autoimmune reactions to cells that die by natural processes. PME researchers coupled an antigen — a molecule being attacked by the immune system— with a molecule resembling a fragment of an aged cell that the liver would recognize as friend, rather than foe. The team showed how the vaccine could successfully stop the autoimmune reaction associated with a multiple-sclerosis-like disease.

“In the past, we showed that we could use this approach to prevent autoimmunity,” said Jeffrey Hubbell, the Eugene Bell Professor in Tissue Engineering and lead author of the new paper. “But what is so exciting about this work is that we have shown that we can treat diseases like multiple sclerosis after there is already ongoing inflammation, which is more useful in a real-world context.”

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Purpose: Wolfiporia cocos is frequently used in traditional Chinese medicine to treat depression. However, antidepressant-like effects of the main active ingredients of Wolfiporia cocos, total triterpenes of Wolfiporia cocos (TTWC), are not well studied. This study aimed to investigate those effects and explore their specific mechanisms of action in depth. Methods: Chemical components of TTWC were analyzed using LC-MS. Depression-like behavior in rats were induced by chronic unpredictable mild stress (CUMS). The suppressive effects of TTWC (60120240 mg/kg) against CUMS-induced depression-like behavior were evaluated using the forced swimming test (FST), open field test (OFT) and sucrose preference test (SPT). Levels of 5-hydroxytryptamine (5-HT), glutamate (GLU), corticotropin-releasing hormone (CRH), interleukin-1 beta (IL-1beta), interleukin-18 (IL-18), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in different groups were determined by ELISA. Western blotting (WB) was used to detect the expression of NLRP3, ASC, pro-caspase-1, caspase-1, pro-IL-1beta, IL-1beta, pro-IL-18, and IL-18 in the prefrontal cortex. Additionally, the mRNA levels of NLRP3, ASC, caspase-1, IL-1beta and IL-18 were detected by RT-PCR. Results: A total of 69 lanostane-type triterpene acids of TTWC were identified. The results showed that TTWC exhibited an antidepressant-like effect in CUMS rats, reversed the decreased sugar preference in the SPT, reduction of immobility time in the FST, reduced the rest time, increased the total moving distance in the OFT. TTWC increased 5-HT levels and decreased GLU levels in the hippocampus. Moreover, TTWC decreased CRH levels in serum, indicating the regulation of over-activation of the hypothalamic-pituitary-adrenal (HPA) axis. In addition, reduced serum levels of IL-1beta, IL-18, IL-6, and TNF-alpha. The WB results implied that TTWC inhibited the expression of NLRP3, ASC, caspase-1, IL-1beta, and IL-18 in the prefrontal cortex and enhanced the expression of pro-caspase-1, pro-IL-1beta, and pro-IL-18. Although most of the results were not significant, PCR results showed that TTWC inhibited the expression of NLRP3, ASC, caspase-1, IL-1beta, and IL-18 in the prefrontal cortex. Conclusion: TTWC treatment exerted an antidepressant-like effect and regulates neurotransmitters, HPA axis and NLRP3 signaling pathway. These results indicated the potential of TTWC in preventing the development of depression.

Keywords: NLRP3 pathway; Wolfiporia cocos (schwein.) ryvarden & gilb; chronic unpredictable mild stress; depression; hypothalamic-pituitary-adrenal axis; neurotransmitter; triterpenes.

Copyright © 2022 Pan, Chen, Han, Luo, Zhang, Zhang, Zhang, Zhou, Li, Fang, Wang and Ye.

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Science is hard. The science of consciousness is particularly hard, beset with philosophical difficulties and a scarcity of experimental data.

So in June, when the results of a head-to-head experimental contest between two rival theories were announced at the 26th annual meeting of the Association for the Scientific Study of Consciousness in New York City, they were met with some fanfare.

The results were inconclusive, with some favoring “integrated information theory” and others lending weight to the “global workspace theory”. The outcome was covered in both Science and Nature, as well as larger outlets including the New York Times and The Economist.

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Incredible though it may seem, a wriggly roundworm with no eyes, no spine, and no brain to speak of may still possess the most basic of animal emotions.

In recent research, the nematode, Caenorhabditis elegans, has shown a persistent negative reaction when given a quick electric zap. For many minutes after receiving the short and sharp shock, this species continued to ‘flee’ at high speeds in the laboratory.

Researchers from Nagoya City University in Japan and Northeastern University in the US say that the long-lasting response, which looks like the worm ‘running’ away, is indicative of a fear-like brain state.

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