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Category: neuroscience – Page 257

Key mechanisms identified for regeneration of neurons

Neurological disorders, such as trauma, stroke, epilepsy, and various neurodegenerative diseases, often lead to the permanent loss of neurons, causing significant impairments in brain function. Current treatment options are limited, primarily due to the challenge of replacing lost neurons.

Direct neuronal , a complex procedure that involves changing the function of one type of cell into another, offers a promising strategy.

In cell culture and in living organisms, glial cells—the non-neuronal cells in the central nervous system—have been successfully transformed into functional neurons. However, the processes involved in this reprogramming are complex and require further understanding. This complexity presents a challenge, but also a motivation, for researchers in the field of neuroscience and regenerative medicine.

Study finds brain stores motor memories differently based on decision uncertainty

A study published in the journal Nature Human Behaviour challenges the belief that identical physical actions are governed by the same motor memory, regardless of the decision-making process involved. Researchers from the National Institute of Information and Communications Technology (NICT) and HONDA R&D Co., Ltd. have discovered that the brain differentiates and stores motor memories based on the level of uncertainty experienced during decision-making.

In a football (soccer) penalty shootout, a player may decide to confidently kick the ball to the right corner upon observing the goalkeeper moving in the opposite direction. Alternatively, the player might make the same kick while being unsure about the goalkeeper’s movement.

Although the physical action—kicking the ball to the right—is identical in both scenarios, this new study reveals that the brain tags these actions differently based on the decision uncertainty involved. This discovery suggests that motor memories are not simply repetitions of the same action but are influenced by the cognitive processes leading up to them.

Stanford Engineers a Pocket-Sized Titanium-Sapphire Super Laser

In a single leap from tabletop to the microscale, engineers at Stanford University have produced the world’s first practical titanium-sapphire laser on a chip.

Researchers have developed a chip-scale Titanium-sapphire laser that is significantly smaller and less expensive than traditional models, making it accessible for broader applications in quantum optics, neuroscience, and other fields. This new technology is expected to enable labs to have hundreds of these powerful lasers on a single chip, fueled by a simple green laser pointer.

As lasers go, those made of Titanium-sapphire (Ti: sapphire) are considered to have “unmatched” performance. They are indispensable in many fields, including cutting-edge quantum optics, spectroscopy, and neuroscience. But that performance comes at a steep price. Ti: sapphire lasers are big, on the order of cubic feet in volume. They are expensive, costing hundreds of thousands of dollars each. And they require other high-powered lasers, themselves costing $30,000 each, to supply them with enough energy to function.

Scientists Uncover Brain-Boosting Potential of Vitamin B6

Researchers found that inhibiting the degradation of vitamin B6 in cells using 7,8-Dihydroxyflavone enhances brain functions and could offer a new treatment method for mental and neurodegenerative disorders.

Vitamin B6 plays a crucial role in brain metabolism. Consequently, low levels of vitamin B6 are linked to memory and learning impairments, depressive moods, and clinical depression in various mental disorders. In the elderly, insufficient vitamin B6 is associated with memory decline and dementia.

Although some of these observations were made decades ago, the exact role of vitamin B6 in mental illness is still largely unclear. What is clear, however, is that an increased intake of vitamin B6 alone, for example in the form of dietary supplements, is insufficient to prevent or treat disorders of brain function.

Parkinson’s Link to Gut Bacteria Suggests Unexpected, Simple Treatment

Researchers have suspected for some time that the link between our gut and brain plays a role in the development of Parkinson’s disease.

A new study just identified gut microbes likely to be involved and linked them with decreased riboflavin (vitamin B2) and biotin (vitamin B7), pointing the way to an unexpectedly simple treatment that may help: B vitamins.

“Supplementation of riboflavin and/or biotin is likely to be beneficial in a subset of Parkinson’s disease patients, in which gut dysbiosis plays pivotal roles,” Nagoya University medical researcher Hiroshi Nishiwaki and colleagues write in their published paper.

Activating molecular target reverses multiple hallmarks of aging

MD Anderson researchers identify molecule that reduces age-related inflammation and improves brain and muscle function in preclinical models.

MD Anderson News Release June 21, 2024

Researchers at The University of Texas MD Anderson Cancer Center have demonstrated that therapeutically restoring…

The study, published today in Cell, identified a small molecule compound that restores physiological levels of telomerase reverse transcriptase (TERT), which normally is repressed with the onset of aging. Maintenance of TERT levels in aged lab models reduced cellular senescence and tissue inflammation, spurred new neuron formation with improved memory, and enhanced neuromuscular function, which increased strength and coordination.

The researchers show that TERT functions not only to extend telomeres, but also acts as a transcription factor to affect the expression of many genes directing neurogenesis, learning and memory, cellular senescence, and inflammation.

What’s going on in our Brains when we Plan? Study uncovers how Mental Simulations rely on Stored Memories

In pausing to think before making an important decision, we may imagine the potential outcomes of different choices we could make. While this “mental simulation” is central to how we plan and make decisions in everyday life, how the brain works to accomplish this is not well understood.

An international team of scientists has now uncovered neural mechanisms used in planning. Its results, published in the journal Nature Neuroscience, suggest that an interplay between the brain’s prefrontal cortex and hippocampus allows us to imagine future outcomes in order to guide our decisions.

“The prefrontal cortex acts as a ‘simulator,’ mentally testing out possible actions using a cognitive map stored in the hippocampus,” explains Marcelo Mattar, an assistant professor in New York University’s Department of Psychology and one of the paper’s authors.

Daniel Dennett on the Evolution of the Mind, Consciousness and AI

Want to join the debate? Check out the Intelligence Squared website to hear about future live events and podcasts: http://www.intelligencesquared.com.
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How come there are conscious minds?
How do language and culture evolve?
Should we still teach children things which computers can do better?
Will our smart electronic devices rob us of our intelligence?
Will human intelligence and AI co-evolve?

These are some of the intriguing questions that Daniel Dennett, one of the most influential and provocative thinkers of modern times, sought to answer when he came to the Intelligence Squared stage to discuss his lifetime’s work on the evolution of the human mind. Dennett’s cross-disciplinary approach – encompassing neuroscience, evolutionary biology and artificial intelligence – has been widely acclaimed and helped redefine the role of the philosopher for our age.

In this exclusive event, Dennett explored the major themes of his forthcoming book, ‘From Bacteria to Bach and Back’, including how our minds came into existence, how our brains work, and how ideas are culturally transmitted. He exploded many of the notions we take for granted about how we think – such as the idea of the individual – offering instead a bold new explanation of human consciousness which views it largely as a product of cultural evolution built up over millennia.

Sharing the stage with Dennett were key figures from the next generation of scientists, AI experts, philosophers and artists, with whom he will engage on what it means to be human.