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Category: neuroscience – Page 234

Neural circuits reveal new insights into how we navigate space and store memories

Researchers led by the University of California, Irvine are the first to reveal how two neural circuits located in the brain’s retrosplenial cortex are directly linked to spatial navigation and memory storage. This discovery could lead to more precise medical treatments for Alzheimer’s disease and other cognitive disorders by allowing them to target pathway-specific neural circuits.

The study, published in Molecular Psychiatry, identified two types of RSC pathways, connected to different parts of the brain, each with its own pattern of inputs and functions.

“By demonstrating how specific circuits in the RSC contribute to different aspects of cognition, our findings provide an anatomical foundation for future studies and offer new insights into how we learn and remember the space around us,” said lead and co-corresponding author Xiangmin Xu, UC Irvine Chancellor’s Professor of anatomy and neurobiology and director of the campus’s Center for Neural Circuit Mapping.

Neuralink Competitor Restores Vision in Blind Patients With Eye Implant

Science Corporation, a biotech startup launched by a Neuralink cofounder, claims that it’s achieved a breakthrough in brain-computer interface technology that can help patients with severe vision loss.

In preliminary clinical trials, legally blind patients who had lost their central vision received the company’s retina implants, which restored their eyesight and even allowed them to read books and recognize faces, the startup announced last week.

“To my knowledge, this is the first time that restoration of the ability to fluently read has ever been definitively shown in blind patients,” CEO Max Hodak, who was president of Neuralink before founding Science Corp, said in a statement.

Consciousness may stem from unseen dimensions beyond our reality

Consciousness has long intrigued thinkers, from ancient philosophers to contemporary neuroscientists. It is a complex phenomenon we encounter daily, yet we often find it difficult to fully define or comprehend.

This elusive aspect of our existence encompasses our thoughts, emotions, perceptions, and self-awareness.

Despite significant advancements in fields like cognitive science and psychology, the true nature of consciousness remains one of humanity’s most profound mysteries.

Indicators of an aging brain: A 20-year study

Johns Hopkins University-led researchers, working with the Biomarkers for Older Controls at Risk for Dementia (BIOCARD) cohort, have found that certain factors are linked to faster brain shrinkage and quicker progression from normal thinking abilities to mild cognitive impairment (MCI). People with type 2 diabetes and low levels of specific proteins in their cerebrospinal fluid showed more rapid brain changes and developed MCI sooner than others.

Long-term studies tracking changes over many years are rare but valuable. Previous research mostly provided snapshots in time, which can’t show how individual brains change over the years. By following participants for up to 27 years (20-year median), this study offers new insights into how health conditions might speed up brain aging.

In a study, “Acceleration of Brain Atrophy and Progression From Normal Cognition to Mild Cognitive Impairment,” published in JAMA Network Open, researchers used the BIOCARD cohort to examine associated with the acceleration of brain atrophy and progression from normal cognition to MCI. An Invited Commentary is also available.

Minimally invasive neural interface allows brain access without skull opening

A team of researchers led by Rice University’s Jacob Robinson and the University of Texas Medical Branch’s Peter Kan has developed a technique for diagnosing, managing and treating neurological disorders with minimal surgical risks. The team’s findings were published in Nature Biomedical Engineering.

While traditional approaches for interfacing with the nervous system often require creating a hole in the skull to with the brain, the researchers have developed an innovative method known as endocisternal interfaces (ECI), allowing for electrical recording and stimulation of neural structures, including the brain and , through (CSF).

“Using ECI, we can access multiple brain and spinal cord structures simultaneously without ever opening up the skull, reducing the risk of complications associated with traditional surgical techniques,” said Robinson, professor of electrical and computer engineering and bioengineering.

Uncovering Hidden Brain Signals

Summary: A recent study offers new insights into how brain regions coordinate during rest, using resting-state fMRI (rsfMRI) and neural recordings in mice. By comparing blood flow patterns with direct neural activity, researchers found that some brain activity remains “invisible” in traditional rsfMRI scans. This hidden activity suggests that current brain imaging techniques may miss key elements of neural behavior.

The findings, potentially applicable to human studies, may refine our understanding of brain networks. Further research could improve the accuracy of interpreting brain activity.

When muscles work out, they help neurons grow: Biochemical and physical effects of exercise could help heal nerves

This study explores how muscle contractions, such as those that occur during exercise, influence motor neurons—the cells responsible for controlling muscle movement.

There’s no doubt that exercise does a body good. Regular activity not only strengthens muscles but can bolster our bones, blood vessels, and immune system.

Now, MIT engineers have found that exercise can also have benefits at the level of individual neurons. They observed that when muscles contract during exercise, they release a soup of biochemical signals called myokines.

In the presence of these -generated signals, neurons grew four times further compared to neurons that were not exposed to myokines. These cellular-level experiments suggest that exercise can have a significant biochemical effect on nerve growth.

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