Understanding the cellular composition of tissues is key for interpreting neural disease origin, progression and more. This whitepaper explores a method to aid this.
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To interpret neural disease origin, progression, prognosis and treatment options, it is essential to understand the cellular and spatial composition of neural tissues.
Imaging mass cytometry (IMC) overcomes the limitations of traditional cyclic fluorescent methods to uncover the spatial distribution of over 40 distinct protein markers simultaneously, without interference from the tissue degradation and autofluorescence artifacts usually found in brain tissue.
This whitepaper explores the translational and clinical applications of IMC to develop biomarkers and future treatment strategies in neuro-oncology and neurodegenerative studies.
Synchronicity!đ Just a few hours ago I watched a video which stated that the philosopher Henri Bergson argued our linear perception of time limited our ability to appreciate the relationship between time and consciousness.
What if our understanding of time as a linear sequence of events is merely an illusion created by the brainâs processing of reality? Could time itself be an emergent phenomenon, arising from the complex interplay of quantum mechanics, relativity, and consciousness? How might the brainâs multidimensional computations, reflecting patterns found in the universe, reveal a deeper connection between mind and cosmos? Could Quantum AI and Reversible Quantum Computing provide the tools to simulate, manipulate, and even reshape the flow of time, offering practical applications of D-Theory that bridge the gap between theoretical physics and transformative technologies? These profound questions lie at the heart of Temporal Mechanics: D-Theory as a Critical Upgrade to Our Understanding of the Nature of Time, 2025 paper and book by Alex M. Vikoulov. D-Theory, also referred to as Quantum Temporal Mechanics, Digital Presentism, and D-Series, challenges conventional views of time as a fixed, universal backdrop to reality and instead redefines it as a dynamic interplay between the mind and the cosmos.
Time, as experienced by humans, is more than a sequence of events dictated by physical laws. It emerges from our awareness of change, a psychological construct shaped by consciousness. Recent advancements in neuroscience, quantum physics, and cognitive science reveal fascinating parallels between the brain and the universe. Studies suggest that neural processes operate in up to 11 dimensions, echoing M-Theoryâs depiction of a multiverse with similar dimensionality. These insights hint at a profound structural resemblance, where the brain and the cosmos mirror each other as interconnected systems of information processing.
Quantum Temporal Mechanics goes further, positing that consciousness not only perceives time but actively participates in its manifestation. In quantum theory, the observer plays a pivotal role in collapsing wavefunctions, a process that may extend beyond the microcosm to the fabric of reality itself. Various interpretations of quantum mechanics, such as Quantum Bayesianism and Consciousness Causes Collapse theory, support the idea that the observerâs awareness helps shape how time unfolds. In this framework, the flow of time becomes a participatory phenomenon, where consciousness and the universe co-create the temporal experience.
The implications of this perspective are far-reaching. By placing consciousness at the center of temporal reality, D-Theory suggests that the universe operates as a self-simulating quantum neural networkâa vast, intelligent system continuously evolving and self-regulating. Reality itself becomes an active, dynamic process in which every quantum event contributes to the universeâs collective intelligence, much like neurons firing in a biological brain. This conceptualization reimagines the universe as a living, thinking entity, where time, space, and experience are constructs shaped by a universal consciousness.
Researchers at the CUNY Graduate Center have made a groundbreaking discovery in Alzheimerâs disease research, identifying a critical link between cellular stress in the brain and disease progression.
Their study focuses on microglia, the brainâs immune cells, which play dual roles in either protecting or harming brain health. By targeting harmful microglia through specific pathways, this research opens new avenues for potentially reversing Alzheimerâs symptoms and providing hope for effective treatments.
Researchers from Kyushu University have developed an innovative technique to non-invasively measure two key signals, membrane voltage and intracellular calcium levels, at the same time, in neurons of awake animals. This new method offers a more complete understanding of how neurons function, revealing that these two signals encode different information for sensory stimuli. The research was published in Communications Biology on September 16, 2024.
Neurons are cells that act as the brainâs fundamental building blocks, transmitting information through electrical signals. When a neuron receives a stimulus, changes in membrane voltage (the electrical charge across the neuron cell membrane) trigger the neuron to activate, causing rapid changes in membrane voltage to propagate along the neuron as an electrical signal. These changes in membrane voltage then lead to changes in intracellular calcium (calcium levels inside neurons).
Historically, measuring membrane voltage has involved invasive techniques using electrodes. As a non-invasive alternative, scientists have developed techniques to measure calcium activity using fluorescent proteins that are sensitive to calcium ions as sensors, providing an indirect proxy for neuron activity. However, these different methods mean that the two signals have almost always been studied separately, making it challenging to understand how they interact in real-time and to identify their distinct functions in living animals.
The two professions associated with the lowest levels of death due to Alzheimerâs disease may be surprising.
Taxi and ambulance drivers were found to have the lowest proportion of deaths of more than 440 occupations that were considered in a new observation-based study from Massachusetts physicians.
Alzheimerâs disease is a type of dementia that affects memory, thinking, and behavior. It impacts millions of Americans and is one of the top 10 causes of death in the US.
For the first time, researchers used lab-grown organoids created from tumors of individuals with glioblastoma (GBM) to accurately model a patientâs response to CAR T cell therapy in real time. The organoidâs response to therapy mirrored the response of the actual tumor in the patientâs brain. That is, if the tumor-derived organoid shrunk after treatment, so did the patientâs actual tumor, according to new research from the Perelman School of Medicine, published in Cell Stem Cell.
Lab-grown tumors respond to cell therapy the same as tumors in the patientsâ brains, according to researchers at Penn Medicine.
What lies ahead in the aftermath of the Technological Singularity? Could the latest scientific breakthroughs refine our theological understanding? Do we live in a simulated multiverse? Are we alone in the universe? Can we achieve cybernetic immortality? When and by what means might we transcend our human condition? These profound inquiries are at the core of this enlightening volume.
Ecstadelic Media Group releases THEOGENESIS: Transdimensional Propagation & Universal Expansion, The Cybernetic Theory of Mind series by Alex M. Vikoulov as an Audible audiobook in addition to a previously released Kindle eBook (Press Release, Burlingame, CA, USA, December 21, 2024 07.17 AM PST)
In a paper published in the journal Neuroscience of Consciousness psychology researchers from the University of Technology Sydney (UTS) worked with 54 participants to examine the effects of surveillance on an essential function of human sensory perception â the ability to detect another personâs gaze.
Lead author, Associate Professor of neuroscience and behaviour Kiley Seymour, said previous research has established the effects on conscious behaviour when people know they are being watched, but the new study provided the first direct evidence that being watched also has an involuntary response.
âWe know CCTV changes our behaviour, and thatâs the main driver for retailers and others wanting to deploy such technology to prevent unwanted behaviour,â Associate Professor Seymour said.
However, we show itâs not only overt behaviour that changes â our brain changes the way it processes information.
We found direct evidence that being conspicuously monitored via CCTV markedly impacts a hardwired and involuntary function of human sensory perception â the ability to consciously detect a face.
Itâs a mechanism that evolved for us to detect other agents and potential threats in our environment, such as predators and other humans, and it seems to be enhanced when weâre being watched on CCTV.
Our surveilled participants became hyper aware of face stimuli almost a second faster than the control group. This perceptual enhancement also occurred without participants realising it.
The innovation offers potential advancements in diagnosing conditions like arrhythmia and Alzheimerâs.
Researchers at MIT have unveiled a biosensing technique that uses tiny, wireless antennas to monitor electrical signals in biological systems with unprecedented precision.
By eliminating the need for wires and amplifiers, the innovation simplifies cellular studies, offering potential advancements in diagnosing conditions like arrhythmia and Alzheimerâs and enabling more targeted treatments.
Electrical signals are fundamental to cellular communication, yet traditional methods for measuring them are cumbersome and limited in scope.
