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The prediction stems from a project to translate tests currently used in research into aids for routine diagnosis in hospitals.

In a recent study published in Frontiers in Psychology, researchers evaluate the association between paternal mental health and a child’s development during middle childhood.

Study: Longitudinal associations between paternal mental health and child behavior and cognition in middle childhood. Image Credit: PeopleImages.com — Yuri A/Shutterstock.com.

The human brain is three times bigger than a chimp’s and more spherical than a Neanderthal’s. Within a maze of bumps and grooves, neurons converse in distinct patterns that give humans unique cognitive abilities.

Scientists haven’t fully deciphered those patterns. But researchers at UT Southwestern Medical Center are determined to solve the molecular mystery of what makes us human.

In a study published in the journal Nature, they compared brain cell types and activities among humans, chimpanzees and rhesus monkeys. Human brains had more of a kind of cell that may help them adapt based on new experience and heal from injury. Certain human neurons also had more of a gene that affects language development.

Summary: New study on mice decision-making reveals that choice is not a singular moment but a reflection of the brain’s preexisting state.

The research, using Buridan’s Assay, suggests that the mice’s brain constantly broadcasts its goal, even before options are available, with patterns of neuron activity predicting choice.

Hunger and thirst don’t directly drive behavior; instead, they modulate the brain’s goal-setting, with an element of randomness causing switches between needs, ensuring both are met over time.

The University of Oxford researchers for the first time showcased that neural cells can be 3D printed to replicate the structure of the brain’s outer layer: the cerebral cortex.

In a significant breakthrough, scientists have created brain tissue using human stem cells through 3D printing. This advancement holds promise for potential future applications in treating brain injuries.

For the first time, the University of Oxford researchers showcased that neural cells can be 3D printed to replicate the structure of the brain’s outer layer: the cerebral cortex.

Continue reading “New 3D printing approach offers hope for brain injury repair” »

Researchers with the Translational Research in Neuroimaging and Data Science (TReNDs) Center at Georgia State have identified important new methods for accurately identifying possible biomarkers in adolescent brains that can reliably predict cognitive developments and psychiatric issues.

A new study, published in Nature Mental Health, represents the first large-scale analysis of its kind in which researchers analyzed functional network connectivity (FNC) across scans and identified associations with a diverse range of health measures in children. Researchers believe that inferences about early cognitive and psychiatric behaviors in children may be made using these intra-subject variabilities as a useful biomarker.

Researchers studied four scans from more than 9,000 subjects ages 9 to 11.

In a small study, researchers at the National Institutes of Health have found that positron emission tomography (PET) scans of the heart may identify people who will go on to develop Parkinson’s disease or Lewy body dementia among those at-risk for these diseases.

The findings, published in the Journal of Clinical Investigation and led by scientists at the National Institute of Neurological Disorders and Stroke (NINDS), part of NIH, may advance efforts to detect the earliest changes that years later lead to Parkinson’s disease and Lewy body dementia.

In 34 people with Parkinson’s disease risk factors, researchers conducted PET scans of the heart to gain insight into levels of the neurotransmitter norepinephrine. They found that the scans could distinguish individuals who would later be diagnosed with Parkinson’s or Lewy body dementia—both are brain diseases caused by abnormal deposits of the protein alpha-synuclein that form clumps known as Lewy bodies. The research was conducted at the NIH Clinical Center, currently the only location for ¹⁸ F-dopamine PET scanning.

Stem cell biologist Helen Blau of Stanford University School of Medicine and colleagues previously found that blocking 15-PGDH in old mice restored their withered muscles and improved their strength after a month of treatment. On the flip side, young mice lost muscle and became weaker after their levels of this enzyme were increased for a month.

Blau’s team has now found that 15-PGDH accumulates in the muscles of old mice as the connections that allow communication between muscles and nerves are lost, another consequence of aging. Treating old mice for one month with a drug that inhibits 15-PGDH restored these connections, called synapses, between muscle fibers and motor nerve cells, and boosted the animals’ strength, the team reports in the Oct. 11 Science Translational Medicine. Those synapses are how the brain directs muscles to move.

The findings suggest that blocking the gerozyme 15-PGDH may be a way to help recover strength that has diminished due to nerve injuries, motor nerve cell diseases or aging.

Researchers led by Mroj Alassaf at the Fred Hutchinson Cancer Research Center in the United States have discovered a link between obesity and neurodegenerative disorders like Alzheimer’s disease.

Using the common fruit fly, the research shows that a high-sugar diet—a hallmark of obesity—causes insulin resistance in the brain, which in turn reduces the ability to remove neuronal debris, thus increasing the risk of neurodegeneration.

Publishing November 7 in the open access journal PLOS Biology, the research will impact therapies designed to reduce the risk of developing neurodegenerative diseases.