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Cognitive Performance and Long-term Exposure to Outdoor Air Pollution: Findings from the Harmonised Cognitive Assessment Protocol Sub-Study of the English Longitudinal Study of Ageing (ELSA-HCAP)

Although air pollution is associated with worse cognitive performance, whether these relationships differ by cognitive domain and which sources of air pollution are particularly detrimental to cognition remains understudied. This study examined associations between cognitive scores across three domains in older adults and 8–10 years of exposure to air pollutants (NO2, total PM2.5, and PM2.5 from different emission sources).

Methods.

We used data from the 2018 Harmonized Cognitive Assessment Protocol sub-study of the English Longitudinal Study of Ageing (N=1,127). Outdoor concentrations of each pollutant were estimated for 2008÷10−2017 and summarised using means and group-based trajectories. Linear regression models were used to assess long-term air pollution exposure relationships with memory, executive function, language, and global cognitive function after adjustment for key individual and neighbourhood-level confounders.

A Grain of Brain, 523 Million Synapses, and the Most Complicated Neuroscience Experiment Ever Attempted

A team of over 150 scientists has achieved what once seemed impossible: a complete wiring and activity map of a tiny section of a mammalian brain. This feat, part of the MICrONS Project, rivals the Human Genome Project in ambition and scope, using cutting-edge AI, microscopy, and teamwork to map

Nathan Piland of Nunex: From Medtech Concept to Commercialization

In this episode of the Neural Implant Podcast, we’re joined by Nathan Piland, CEO of Nunex, a consulting firm that specializes in helping MedTech companies navigate the complex journey from concept to commercialization. With over two decades of experience across regulatory strategy, product development, and market access, Nathan shares invaluable insights into the critical steps for MedTech startups and established companies looking to succeed in today’s competitive landscape. Tune in as we discuss the unique challenges of the neurotech industry, strategic consulting for MedTech ventures, and how Nunex is helping companies grow and scale through a holistic, tailored approach.

Top 3 Takeaways:

NEURD: A new software to proofread the map of the brain

A revolutionary blueprint is emerging from a fragment of brain tissue, promising new insights into the mysteries of the human mind. At the heart of this innovation is NEURD—short for “NEURal Decomposition”—a groundbreaking software package developed by researchers at Baylor College of Medicine.

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With NEURD, the time-consuming process of mapping the intricate “street map” of brain connections is being transformed, enabling faster error detection and data corrections that pave the way for discovery.

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