The startup, a rival to Elon Musk’s Neuralink, launched a registry to recruit patients and healthcare providers for the trial.
Category: neuroscience – Page 155
While an estimated 5 million Americans live with a disability that is related to traumatic brain injury (TBI), there are few treatment options for TBIs, which can affect people in a number of occupations like professional sports or some military positions, as well as anyone who suffers head trauma. But scientists have now found that a protein called TDP-43 may promote nerve damage immediately following an injury. When another protein was blocked in a mouse model and in human cell lines, this TDP-43-mediated damaged was prevented and some cell death was halted. These findings, which were reported in Cell Stem Cell, could help scientists develop treatment options for TBIs.
“There’s really nothing out there that can prevent the injury or trauma to the brain that cause nerve cell damage,” said corresponding study author Justin Ichida of the University of Southern California. “In more acute stages, patients can have difficulty concentrating and have extreme sensitivity to light and noise. Long term, there is a strong correlation between traumatic brain injury and neurodegenerative diseases, which can ultimately be fatal.”
One of the largest threats to human health is obesity, but now researchers from the University of Aberdeen Rowett Institute have made an important discovery in how the brain controls food intake.
Obesity and being overweight have become the “new normal” in modern times and can lead to a multitude of health problems. We know that excess weight is primarily caused by eating more calories than the body needs; however, new research published in Current Biology has found a specific cluster of cells in the brain that control body weight.
How the brain controls hunger has not been fully defined. The researchers discovered a cluster of brain cells that can be harnessed to reduce food intake and body weight. One way they do this is by turning down cells that stimulate hunger.
Scientists studying learning in mice have inadvertently encountered ‘zombie neurons’ in the brain – not flesh-eating, virus-spreading monsters, but cells that stop interacting normally even though they’re functionally alive. What’s more, they shed new light on learning processes in the brain.
A team from Portugal discovered the cells as part of an investigation into how a part of the brain called the cerebellum learns from the environment around us.
The cerebellum processes sensory information related to motor movements. It helps us walk down a crowded street, or pick up a drink without spilling it, and it’s also important for learning: so if we bump into something, we know how to refine our movement to avoid it next time. Exactly how that learning happens was the subject of this new study.
Scientists develop a human neuron model that efficiently simulates tau protein spread in Alzheimer’s, hinting at new therapeutic targets.
The human brain is a remarkably complex organ, consisting of billions of interconnected neurons. It can be divided into distinct regions, each with specific functions, such as memory and decision-making. Cognition, which includes processes like perception, memory, language, and problem-solving, is all orchestrated by the brain. It’s through these cognitive processes that we perceive and interact with the world around us.
What is special about the structure of the brain compared to other organs? What is the principled way of understanding how the brain works? How does the brain contribute to our sense of Self? Is it possible to compare the brain with the computer? Is it possible to enhance the way that the brain works? What is the brain-basis of language?
These and other questioned are answered by Serious Science experts from leading universities from all around the world. The coursed is comprised of 15 lectures filmed in the period from 2014 to 2020. If you have any questions or comments on the content of this course — please write us at [email protected].
00:00 Connectomics / Jeff Lichtman.
Diagram of Neuron and Microtubules Reference video:
I would like to dedicate this video on Hodgkin and Huxley model of Neurons. That basically explains Neurons as electric circuits with the organization and movement of positive and negative charge. The positive and negative is in the form of ion atoms. The neuron membrane acts as a boundary separating charge with ionic gates embedded in the cell membrane forming the potential for the build-up and movement of ion charge. This process can form signals along the neurons with the potential difference across the cell membrane forming what is called an action potential.
The big question is how can this process of electrical activity form consciousness?
To answer this question we have to look deeper into the process.
When we do this, we find that the movement or action of charged particles like ions emit photon ∆E=hf energy.
Therefore, this whole process can be based on an interpretation of Quantum Mechanics.
Scientists from Washington University in St.
Antibody mobilizes immune cells to clear amyloid plaques, reducing behavioral abnormalities.
Summary: Researchers made a groundbreaking discovery about the maturation process of adult-born neurons in the brain, highlighting the critical role of mitochondrial fusion in these cells. Their study shows that as neurons develop, their mitochondria undergo dynamic changes that are crucial for the neurons’ ability to form and refine connections, supporting synaptic plasticity in the adult hippocampus.
This insight, which correlates altered neurogenesis with neurological disorders, opens new avenues for understanding and potentially treating conditions like Alzheimer’s and Parkinson’s by targeting mitochondrial dynamics to enhance brain repair and cognitive functions.
Weill Cornell Medicine scientists have developed an innovative human neuron model that robustly simulates the spread of tau protein aggregates in the brain—a process that drives cognitive decline in Alzheimer’s disease and frontotemporal dementia. This new model has led to the identification of novel therapeutic targets that could potentially block tau spread.