Lifeboat Foundation

A small nucleus in the brainstem called locus coeruleus (literally the “blue spot,”) is the primary source of a major neuromodulator, norepinephrine (NE), an important mediator of the ‘fight or flight’ response in animals. However, very little is known about the local connections of this small albeit critically important group of neurons. A recent pioneering study published in eLife from the laboratory of Dr. Xiaolong Jiang, investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital and assistant professor at Baylor College of Medicine, now reveals the cellular composition and circuit organization of the locus coeruleus in adult mice.

“In this study, we undertook the arduous task of mapping local connections of NE-producing neurons in the locus coeruleus,” Dr. Jiang said. “This is the first study of such an unprecedented magnitude and detail to be performed on the locus coeruleus, and in fact, on any monoamine neurotransmitter system. Our study has revealed that the neurons in the locus coeruleus have an unexpectedly rich cellular heterogeneity and local wiring logic.”

Locus coeruleus (LC) is known to house the vast majority of norepinephrine-releasing neurons in the brain and regulates many fundamental brain functions including the fight and flight response, sleep/wake cycles, and attention control. Present in the pontine region of the brainstem, LC neurons sense any existential dangers or threats in our external environment and send signals to alert other brain regions of the impending danger.

Breakthroughs don’t often happen in neuroscience, but we just had one. In a tour-de-force, an international team released the full brain connectivity map of the young fruit fly, described in a paper published last week in Science. Containing 3,016 neurons and 548,000 synapses, the map—called a connectome—is the most complex whole-brain wiring diagram to date.

“It’s a ‘wow,’” said Dr. Shinya Yamamoto at Baylor College of Medicine, who was not involved in the work.

Continue reading “The First Complete Brain Map of an Insect May Reveal Secrets for Better AI” »

Baez-Lugo et al. show that increased functional brain connectivity between default mode network and amygdala in resting state after high emotional events is associated to higher anxiety, rumination and negative thoughts in older adults.

Two new effects on TikTok can give users sculpted cheekbones, plumped lips, or a younger look with the push of a button. But this hyper-realistic image-altering tech also spurs backlash. WSJ reporter Sara Ashley O’Brien joins host Zoe Thomas to discuss how these filters work and why some experts say they could damage users’ mental health. Photo: Storyblocks.

Contribution of exercise to brain resilience.

Dropbox is a free service that lets you bring your photos, docs, and videos anywhere and share them easily. Never email yourself a file again!

This video explores what attention really is, what role it plays in learning and why people can’t multitask — the issue of attention residue.

OUTLINE:
0:00 — Sneak peek.
0:20 — Introduction.
0:57 — Why we need attention.
1:46 — Thalamus as attentional filter.
3:06 — Higher attentional systems.
3:40 — Role of attention in learning.
4:42 — Attention residue.
6:00 — Conclusions and references.

Continue reading “Your brain CAN’T Multitask — Here’s why” »

Following a Mediterranean diet may lower the risk for memory and thinking problems in people with multiple sclerosis (MS), a new study suggests.

There’s a tiny, slow-burning ‘fuse’ attached to the ends of all our chromosomes, and as we naturally age, each of our cells loses more and more of that life-giving line.

Researchers in South Korea have now shown this fuse, known as the telomere, is unusually short in the cells of elderly people who are relatively healthy but have noticed early signs of depressive symptoms and cognitive decline, such as memory loss.

The randomized controlled trial presents more evidence for the telomere hypothesis of aging, which posits that all cells hit a point where they can no longer divide and replicate.

You can easily picture yourself riding a bicycle across the sky even though that’s not something that can actually happen. You can envision yourself doing something you’ve never done before—like water skiing—and maybe even imagine a better way to do it than anyone else.

Imagination involves creating a mental image of something that is not present for your senses to detect, or even something that isn’t out there in reality somewhere. Imagination is one of the key abilities that make us human. But where did it come from?

I’m a neuroscientist who studies how children acquire imagination. I’m especially interested in the neurological mechanisms of imagination. Once we identify what brain structures and connections are necessary to mentally construct new objects and scenes, scientists like me can look back over the course of evolution to see when these brain areas emerged—and potentially gave birth to the first kinds of imagination.