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Category: neuroscience – Page 1,001

Healthy Aging Month: How we can all live better longer

Buck Institute on the elimination of aging diseases for this and further generations:

September is Healthy Aging Month, and here at the Buck Institute for Research on Aging, we are on a mission to end the threat of age-related disease for this and future generations. We believe it is possible for people to enjoy healthy lives at age 95 as much as they do at 25, and to achieve that, we’re seeking a more comprehensive understanding of the biology of aging itself.

Over the last century, average human lifespan has been increasing at a rate of approximately 2 years per decade, primarily due to advancements in antibiotics and other medical treatments, as well as improved public health efforts. The U.S. Census Bureau estimates that by 2035, people over the age of 65 will outnumber people under 18 for the first time in U.S. history. This means that there is an increasing population of older adults who suffer in the later years of life from chronic diseases including diabetes, neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, and cancer. While basic scientific research has provided a lot of insight into the causes and potential treatments of individual diseases, the root cause of these and many other chronic diseases is the biological process of aging.

The goal of the Buck Institute and several other aging research groups across the country is to study and understand more about the underlying mechanisms of aging so that we may find new therapeutic targets to help us delay or even eradicate age-related diseases. The results so far are very compelling. By focusing on the biological mechanisms of aging such as cellular senescence (normal cells stop dividing), chronic inflammation, and changes in metabolism, scientists have been able to extend the disease-free lifespan of laboratory model organisms including flies, worms, and mice. The challenge now is to translate these discoveries into the clinic and determine the best preventative practices to maintain health throughout our lifetime.

High-Fiber Diet Reduces Brain Inflammation in Older Mice

A diet rich in fiber helps reduce inflammation in murine brains.

According to a new study performed by University of Illinois researchers and published in Frontiers in Immunology, a diet rich in fiber reduces inflammation in aged mice, both in the guts and the brain. This beneficial reduction is due to high levels of butyrate, which result from the fermentation of fiber during digestion [1].

Study abstract

Aging results in chronic systemic inflammation that can alter neuroinflammation of the brain. Specifically, microglia shift to a pro-inflammatory phenotype predisposing them to hyper-activation upon stimulation by peripheral immune signals. It is proposed that certain nutrients can delay brain aging by preventing or reversing microglial hyperactivation. Butyrate, a short chain fatty acid (SCFA) produced primarily by bacterial fermentation of fiber in the colon, has been extensively studied pharmacologically as a histone deacetylase (HDAC) inhibitor, and serves as an attractive therapeutic candidate, as butyrate has also been shown to be anti-inflammatory and improve memory in animal models. In the present study, we demonstrate that butyrate can attenuate pro-inflammatory cytokine expression in microglia in aged mice.

Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disease with characterization of deficits in progressive memory loss, cognitive and behaviour functions. Mild cognitive impairment (MCI) is a predromal stage of AD, displaying cognitive deficit but neither marked functional impairment nor satisfying established clinical criteria for dementia or probable AD. However, not all MCI patients may eventually progress to AD (progressive MCI, pMCI)https://doi.org/10.1016/j.nicl.2013.10.

(2014)." href="https://www.nature.com/articles/s41598-018-31794-8#ref-CR2" id="ref-link-section-d1856e5935"]2, and some remain unchanged (stable MCI, sMCI), or are recovered from. Therefore, differential diagnosis of MCI types and earlier diagnosis of AD and prediction of disease evolution are difficult

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Brainvoyager “Electronic Fusion” #158 – 15 September 2018

Playlist Electronic Fusion #158, broadcast on 15 September 2018:

01. Plike — Holmesburg 02. Plike — The Monster Study 03. Plike — Subproject 68 04. Plike — Bluebird 05. Plike — Laboratory 12 (Feat. Digibilly) 06. Alpha Wave Movement — Herzschlag Des Universums 07. Alpha Wave Movement — Other Worlds 08. Chris Gate — This Is Syndae 09. Moonbooter — Syndae’s Theme (Boot From Moon Mix) 10. Stefan Erbe — GP 11. Arend Westra — Under The Milky Way 12. Broekhuis, Keller & Schönwälder — Frozen Nights 13. AndAWan — Time To Remember (Ft. Irene Makri) 14. Thought Guild — Tetrahedral Anomalies 15. Erik Seifert — ALICE (A Large Ion Collider Experiment) 16. Wolfgang Roth (Wolfproject) & Jens-H. Kruhl (Wiesenberg) — The Light Belongs To You.

People wearing virtual reality headsets have worse balance and increased mental exertion

New research published in PLOS One has found that virtual reality use impairs physical and cognitive performance while trying to balance.

“I became interested in this topic because virtual reality headsets have recently become widely available, with great potential to make rehabilitation more enjoyable and varied for patients,” said study author Steven M. Peterson of the University of Michigan, Ann Arbor.

“While many studies have explored upper-limb activities, I wanted to understand how immersive and mentally challenging a virtual reality headset is when the user is walking around and not seated. We decided to test the realism of virtual reality by looking for stress at high heights because just the perception of heights can affect how people walk and how cautious they are.”

FDA clears deep transcranial magnetic stimulation device to treat obsessive-compulsive disorder

Promising approach to deliver personalized and non-invasive brain stimulation in clinical settings.

BrainsWay’s Brain Stimulation Device Receives FDA Approval to Treat Obsessive-Compulsive Disorder (IEEE Spectrum):

In 2013, Jerusalem-based BrainsWay began marketing a new type of brain stimulation device that uses magnetic pulses to treat major depressive disorder.

Now, thanks to positive results in a study of 100 patients, the company has received approval from the U.S. Food and Drug Administration (FDA) to market the device for a second psychiatric condition—obsessive-compulsive disorder (OCD) …