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Category: nanotechnology – Page 45

Inside every plant, animal and human cell are billions of molecular machines. They’re made up of proteins, DNA and other molecules, but no single piece works on its own. Only by seeing how they interact together, across millions of types of combinations, can we start to truly understand life’s processes.

In a paper published in Nature, we introduce AlphaFold 3, a revolutionary model that can predict the structure and interactions of all life’s molecules with unprecedented accuracy. For the interactions of proteins with other molecule types we see at least a 50% improvement compared with existing prediction methods, and for some important categories of interaction we have doubled prediction accuracy.

We hope AlphaFold 3 will help transform our understanding of the biological world and drug discovery. Scientists can access the majority of its capabilities, for free, through our newly launched AlphaFold Server, an easy-to-use research tool. To build on AlphaFold 3’s potential for drug design, Isomorphic Labs is already collaborating with pharmaceutical companies to apply it to real-world drug design challenges and, ultimately, develop new life-changing treatments for patients.

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Proteins are the molecular machines that sustain every cell and organism, and knowing what they look like will be critical to untangling how they function normally and malfunction in disease. Now researchers have taken a huge stride toward that goal with the development of new machine learning algorithms that can predict the folded shapes of not only proteins but other biomolecules with unprecedented accuracy.

In a paper published today in Nature, Google DeepMind and its spinoff company Isomorphic Labs announced the latest iteration of their AlphaFold program, AlphaFold3, which can predict the structures of proteins, DNA, RNA, ligands and other biomolecules, either alone or bound together in different embraces. The findings follow the tail of a similar update to another deep learning structure-prediction algorithm, called RoseTTAFold All-Atom, which was published in March in Science.

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In this study, graduate student Keito Kobayashi and Professor Shunsuke Fukami from Tohoku University, along with Dr. Kerem Camsari from the University of California, Santa Barbara, and their colleagues, developed a near-future heterogeneous version of a probabilistic computer tailored for executing probabilistic algorithms and facile manufacturing.

“Our constructed prototype demonstrated that excellent computational performance can be achieved by driving pseudo random number generators in a deterministic CMOS circuit with physical random numbers generated by a limited number of stochastic nanomagnets,” says Fukami. “Specifically speaking, a limited number of probabilistic bits (p-bits) with a stochastic magnetic tunnel junction (s-MTJ), should be manufacturable with a near-future integration technology.”

The researchers also clarified that the final form of the spintronics probabilistic computer, primarily composed of s-MTJs, will yield a four-order-of-magnitude reduction in area and a three-order-of-magnitude reduction in energy consumption compared to the current CMOS circuits when running probabilistic algorithms.

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Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have developed a nanoparticle that can penetrate the blood-brain barrier. Their goal is to kill primary breast cancer tumors and brain metastases in one treatment, and their research shows the method can shrink breast and brain tumors in laboratory studies.

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A Birmingham researcher has developed a new high-throughput device that produces libraries of nanomaterials using sustainable mechanochemical approaches.

Dr. Jason Stafford from the University’s School of Engineering invented the platform to create highly controllable reaction conditions and reduce the substantial amount of time researchers spend generating materials in the laboratory.

The benchtop device is a fully automated unit that can be programmed for parallel synthesis to produce a series of novel materials made in subtly different ways, so creating a library of or product formulations for further testing and optimization.

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