Toggle light / dark theme

Altering the surface of orthopaedic implants has already helped patients – and nanotech can fight infections too

One of medicine’s primary objectives is to trick the body into doing something it doesn’t want to do. We try to convince our immune systems to attack cancer cells (our immune systems don’t normally attack our own bodies), we try to convince neurons to regrow (another unnatural phenomenon), and we try to convince the body to accept foreign bits, such as someone else’s kidney or a fake bone. In order to accomplish this, we try to make parts of our bodies we don’t want, such as cancers, look foreign. We try to make foreign bits that we do want, such as orthopaedic implants, look natural. Nanotechnology, as you might have guessed, can help us do just that.

Read more

Tim Parker, Benzinga Staff Writer

Before scientists create something that has mainstream uses, it often starts as science fiction.

A new technology deep within IBM’s (NYSE: IBM [FREE Stock Trend Analysis]) Singapore research facility isn’t quite ready for the mainstream but when it is, the implications for those who suffer from fungal infections and later, other infections, could have a new ally in their fight but this ally is completely different than current treatments.

If you’re a fan of Star Trek, you’ve seen nanotechnology. These are microscopic machines that get inside machines or in this case, the body, to identify and fix problems.

Scientists have developed a nanomedicine 1,000 times small than a grain of sand that fights fungal infections. Here’s how it works: By creating an electrical charge on each of these tiny particles, they can be programmed to attack only fungal cells while leaving healthy cells alone.

The particles attach themselves to the fungi and rip their cellular membranes apart killing the cell.

This is different than conventional treatments in that it’s a physical attack where the cell is torn apart instead of a drug-like attack where the cell is put to sleep. By killing the cell, there is no opportunity for it to develop a resistance to the nanoparticle. This eliminates the growing problem plaguing doctors: Infections that are increasingly becoming resistant to current therapies.

“It rips the membrane out in a physical attack,” said IBM scientist, James Hedric. “It’s kind of like popping a balloon. We don’t put them to sleep like most drugs do. We kill them. That is why it is so effective. And they can’t adapt to a physical attack. They can adapt to drugs.”

The Lifeboat community doesn’t need me to tell them that a growing number of scientists are dedicating their time and energy into research that could radically alter the human aging trajectory. As a result we could be on the verge of the end of aging. But from an anthropological and evolutionary perspective, humans have always had the desire to end aging. Most human culture groups on the planet did this by inventing some belief structure incorporating eternal consciousness. In my mind this is a logical consequence of A) realizing you are going to die and B) not knowing how to prevent that tragedy. So from that perspective, I wanted to create a video that contextualized the modern scientific belief in radical life extension with the religious/mythological beliefs of our ancestors.

https://www.youtube.com/watch?v=OLftXInDxhM

And if you loved the video, please consider subscribing to The Advanced Apes on YouTube! I’ll be releasing a new video bi-weekly!

(Excerpt)

Beyond the managerial challenges (downside risks) presented by the exponential technologies as it is understood in the Technological Singularity and its inherent futuristic forces impacting the present and the future now, there are also some grave global risks that many forms of management have to tackle with immediately.

These grave global risks have nothing to do with advanced science or technology. Many of these hazards stem from nature and some are, as well, man made.

For instance, these grave global risks ─ embodying the Disruptional Singularity ─ are geological, climatological, political, geopolitical, demographic, social, economic, financial, legal and environmental, among others. The Disruptional Singularity’s major risks are gravely threatening us right now, not later.

Read the full document at http://lnkd.in/bYP2nDC

In this essay I argue that technologies and techniques used and developed in the fields of Synthetic Ion Channels and Ion Channel Reconstitution, which have emerged from the fields of supramolecular chemistry and bio-organic chemistry throughout the past 4 decades, can be applied towards the purpose of gradual cellular (and particularly neuronal) replacement to create a new interdisciplinary field that applies such techniques and technologies towards the goal of the indefinite functional restoration of cellular mechanisms and systems, as opposed to their current proposed use of aiding in the elucidation of cellular mechanisms and their underlying principles, and as biosensors.

In earlier essays (see here and here) I identified approaches to the synthesis of non-biological functional equivalents of neuronal components (i.e. ion-channels ion-pumps and membrane sections) and their sectional integration with the existing biological neuron — a sort of “physical” emulation if you will. It has only recently come to my attention that there is an existing field emerging from supramolecular and bio-organic chemistry centered around the design, synthesis, and incorporation/integration of both synthetic/artificial ion channels and artificial bilipid membranes (i.e. lipid bilayer). The potential uses for such channels commonly listed in the literature have nothing to do with life-extension however, and the field is to my knowledge yet to envision the use of replacing our existing neuronal components as they degrade (or before they are able to), rather seeing such uses as aiding in the elucidation of cellular operations and mechanisms and as biosensors. I argue here that the very technologies and techniques that constitute the field (Synthetic Ion-Channels & Ion-Channel/Membrane Reconstitution) can be used towards the purpose of the indefinite-longevity and life-extension through the iterative replacement of cellular constituents (particularly the components comprising our neurons – ion-channels, ion-pumps, sections of bi-lipid membrane, etc.) so as to negate the molecular degradation they would have otherwise eventually undergone.

While I envisioned an electro-mechanical-systems approach in my earlier essays, the field of Synthetic Ion-Channels from the start in the early 70’s applied a molecular approach to the problem of designing molecular systems that produce certain functions according to their chemical composition or structure. Note that this approach corresponds to (or can be categorized under) the passive-physicalist sub-approach of the physicalist-functionalist approach (the broad approach overlying all varieties of physically-embodied, “prosthetic” neuronal functional replication) identified in an earlier essay.

The field of synthetic ion channels is also referred to as ion-channel reconstitution, which designates “the solubilization of the membrane, the isolation of the channel protein from the other membrane constituents and the reintroduction of that protein into some form of artificial membrane system that facilitates the measurement of channel function,” and more broadly denotes “the [general] study of ion channel function and can be used to describe the incorporation of intact membrane vesicles, including the protein of interest, into artificial membrane systems that allow the properties of the channel to be investigated” [1]. The field has been active since the 1970s, with experimental successes in the incorporation of functioning synthetic ion channels into biological bilipid membranes and artificial membranes dissimilar in molecular composition and structure to biological analogues underlying supramolecular interactions, ion selectivity and permeability throughout the 1980’s, 1990’s and 2000’s. The relevant literature suggests that their proposed use has thus far been limited to the elucidation of ion-channel function and operation, the investigation of their functional and biophysical properties, and in lesser degree for the purpose of “in-vitro sensing devices to detect the presence of physiologically-active substances including antiseptics, antibiotics, neurotransmitters, and others” through the “… transduction of bioelectrical and biochemical events into measurable electrical signals” [2].

Thus my proposal of gradually integrating artificial ion-channels and/or artificial membrane sections for the purpse of indefinite longevity (that is, their use in replacing existing biological neurons towards the aim of gradual substrate replacement, or indeed even in the alternative use of constructing artificial neurons to, rather than replace existing biological neurons, become integrated with existing biological neural networks towards the aim of intelligence amplification and augmentation while assuming functional and experiential continuity with our existing biological nervous system) appears to be novel, while the notion of artificial ion-channels and neuronal membrane systems ion general had already been conceived (and successfully created/experimentally-verified, though presumably not integrated in-vivo).

The field of Functionally-Restorative Medicine (and the orphan sub-field of whole-brain-gradual-substrate-replacement, or “physically-embodied” brain-emulation if you like) can take advantage of the decades of experimental progress in this field, incorporating both the technological and methodological infrastructures used in and underlying the field of Ion-Channel Reconstitution and Synthetic/Artificial Ion Channels & Membrane-Systems (and the technologies and methodologies underlying their corresponding experimental-verification and incorporation techniques) for the purpose of indefinite functional restoration via the gradual and iterative replacement of neuronal components (including sections of bilipid membrane, ion channels and ion pumps) by MEMS (micro-electrocal-mechanical-systems) or more likely NEMS (nano-electro-mechanical systems).

The technological and methodological infrastructure underlying this field can be utilized for both the creation of artificial neurons and for the artificial synthesis of normative biological neurons. Much work in the field required artificially synthesizing cellular components (e.g. bilipid membranes) with structural and functional properties as similar to normative biological cells as possible, so that the alternative designs (i.e. dissimilar to the normal structural and functional modalities of biological cells or cellular components) and how they affect and elucidate cellular properties, could be effectively tested. The iterative replacement of either single neurons, or the sectional replacement of neurons with synthesized cellular components (including sections of the bi-lipid membrane, voltage-dependent ion-channels, ligand-dependent ion channels, ion pumps, etc.) is made possible by the large body of work already done in the field. Consequently the technological, methodological and experimental infrastructures developed for the fields of Synthetic

Ion-Channels and Ion-Channel/Artificial-Membrane-Reconstitution can be utilized for the purpose of a.) iterative replacement and cellular upkeep via biological analogues (or not differing significantly in structure or functional & operational modality to their normal biological counterparts) and/or b.) iterative replacement with non-biological analogues of alternate structural and/or functional modalities.

Rather than sensing when a given component degrades and then replacing it with an artificially-synthesized biological or non-biological analogue, it appears to be much more efficient to determine the projected time it takes for a given component to degrade or otherwise lose functionality, and simply automate the iterative replacement in this fashion, without providing in-vivo systems for detecting molecular or structural degradation. This would allow us to achieve both experimental and pragmatic success in such cellular-prosthesis sooner, because it doesn’t rely on the complex technological and methodological infrastructure underlying in-vivo sensing, especially on the scale of single neuron components like ion-channels, and without causing operational or functional distortion to the components being sensed.

A survey of progress in the field [3] lists several broad design motifs. I will first list the deign motifs falling within the scope of the survey, and the examples it provides. Selections from both papers are meant to show the depth and breadth of the field, rather than to elucidate the specific chemical or kinetic operations under the purview of each design-variety.

For a much more comprehensive, interactive bibliography of papers falling within the field of Synthetic Ion-Channels or constituting the historical foundations of the field, see Jon Chui’s online biography here, which charts the developments in this field up until 2011.

First Survey

Unimolecular ion channels:

Examples include a.) synthetic ion channels with oligocrown ionophores, [5] b.) using a-helical peptide scaffolds and rigid push–pull p-octiphenyl scaffolds for the recognition of polarized membranes, [6] and c.) modified varieties of the b-helical scaffold of gramicidin A [7]

Barrel-stave supramolecules:

Examples of this general class falling include avoltage-gated synthetic ion channels formed by macrocyclic bolaamphiphiles and rigidrod p-octiphenyl polyols [8].

Macrocyclic, branched and linear non-peptide bolaamphiphiles as staves:

Examples of this sub-class include synthetic ion channels formed by a.) macrocyclic, branched and linear bolaamphiphiles and dimeric steroids, [9] and by b.) non-peptide macrocycles, acyclic analogs and peptide macrocycles [respectively] containing abiotic amino acids [10].

Dimeric steroid staves:

Examples of this sub-class include channels using polydroxylated norcholentriol dimer [11].

pOligophenyls as staves in rigid rod b barrels:

Examples of this sub-class include “cylindrical self-assembly of rigid-rod b-barrel pores preorganized by the nonplanarity of p-octiphenyl staves in octapeptide-p-octiphenyl monomers” [12].

Synthetic Polymers:

Examples of this sub-class include synthetic ion channels and pores comprised of a.) polyalanine, b.) polyisocyanates, c.) polyacrylates, [13] formed by i.) ionophoric, ii.) ‘smart’ and iii.) cationic polymers [14]; d.) surface-attached poly(vinyl-n-alkylpyridinium) [15]; e.) cationic oligo-polymers [16] and f.) poly(m-phenylene ethylenes) [17].

Helical b-peptides (used as staves in barrel-stave method):

Examples of this class include: a.) cationic b-peptides with antibiotic activity, presumably acting as amphiphilic helices that form micellar pores in anionic bilayer membranes [18].

Monomeric steroids:

Examples of this sub-class falling include synthetic carriers, channels and pores formed by monomeric steroids [19], synthetic cationic steroid antibiotics [that] may act by forming micellar pores in anionic membranes [20], neutral steroids as anion carriers [21] and supramolecular ion channels [22].

Complex minimalist systems:

Examples of this sub-class falling within the scope of this survey include ‘minimalist’ amphiphiles as synthetic ion channels and pores [23], membrane-active ‘smart’ double-chain amphiphiles, expected to form ‘micellar pores’ or self-assemble into ion channels in response to acid or light [24], and double-chain amphiphiles that may form ‘micellar pores’ at the boundary between photopolymerized and host bilayer domains and representative peptide conjugates that may self assemble into supramolecular pores or exhibit antibiotic activity [25].

Non-peptide macrocycles as hoops:

Examples of this sub-class falling within the scope of this survey include synthetic ion channels formed by non-peptide macrocycles acyclic analogs [26] and peptide macrocycles containing abiotic amino acids [27].

Peptide macrocycles as hoops and staves:

Examples of this sub-class include a.) synthetic ion channels formed by self-assembly of macrocyclic peptides into genuine barrel-hoop motifs that mimic the b-helix of gramicidin A with cyclic b-sheets. The macrocycles are designed to bind on top of channels and cationic antibiotics (and several analogs) are proposed to form micellar pores in anionic membranes [28]; b.) synthetic carriers, antibiotics (and analogs) and pores (and analogs) formed by macrocyclic peptides with non-natural subunits. [Certain] macrocycles may act as b-sheets, possibly as staves of b-barrel-like pores [29]; c.) bioengineered pores as sensors. Covalent capturing and fragmentations [have been] observed on the single-molecule level within engineered a-hemolysin pore containing an internal reactive thiol [30].

Summary

Thus even without knowledge of supramolecular or organic chemistry, one can see that a variety of alternate approaches to the creation of synthetic ion channels, and several sub-approaches within each larger ‘design motif’ or broad-approach, not only exist but have been experimentally verified, varietized and refined.

Second Survey

The following selections [31] illustrate the chemical, structural and functional varieties of synthetic ions categorized according to whether they are cation-conducting or anion-conducting, respectively. These examples are used to further emphasize the extent of the field, and the number of alternative approaches to synthetic ion-channel design, implementation, integration and experimental-verification already existent. Permission to use all the following selections and figures were obtained from the author of the source.

There are 6 classical design-motifs for synthetic ion-channels, categorized by structure, that are identified within the paper:


A: unimolecular macromolecules,
B: complex barrel-stave,
C: barrel-rosette,
D: barrel hoop, and
E: micellar supramolecules.

Cation Conducting Channels:

UNIMOLECULAR

“The first non-peptidic artificial ion channel was reported by Kobuke et al. in 1992” [33].

“The channel contained “an amphiphilic ion pair consisting of oligoether-carboxylates and mono- (or di-) octadecylammoniumcations. The carboxylates formed the channel core and the cations formed the hydrophobic outer wall, which was embedded in the bilipid membrane with a channel length of about 24 to 30 Å. The resultant ion channel, formed from molecular self-assembly, is cation selective and voltage-dependent” [34].

“Later, Kokube et al. synthesized another channel comprising of resorcinol based cyclic tetramer as the building block. The resorcin-[4]-arenemonomer consisted of four long alkyl chains which aggregated to forma dimeric supramolecular structure resembling that of Gramicidin A” [35]. “Gokel et al. had studied [a set of] simple yet fully functional ion channels known as “hydraphiles” [39].

“An example (channel 3) is shown in Figure 1.6, consisting of diaza-18-crown-6 crown ether groups and alkyl chain as side arms and spacers. Channel 3 is capable of transporting protons across the bilayer membrane” [40].

“A covalently bonded macrotetracycle4 (Figure 1.8) had shown to be about three times more active than Gokel’s ‘hydraphile’ channel, and its amide-containing analogue also showed enhanced activity” [44].

“Inorganic derivative using crown ethers have also been synthesized. Hall et. al synthesized an ion channel consisting of a ferrocene and 4 diaza-18-crown-6 linked by 2 dodecyl chains (Figure 1.9). The ion channel was redox-active as oxidation of the ferrocene caused the compound to switch to an inactive form” [45]

B STAVES:

“These are more difficult to synthesize [in comparison to unimolecular varieties] because the channel formation usually involves self-assembly via non-covalent interactions” [47].“A cyclic peptide composed of even number of alternating D- and L-amino acids (Figure 1.10) was suggested to form barrel-hoop structure through backbone-backbone hydrogen bonds by De Santis” [49].

“A tubular nanotube synthesized by Ghadiri et al. consisting of cyclic D and L peptide subunits form a flat, ring-shaped conformation that stack through an extensive anti-parallel β-sheet-like hydrogen bonding interaction (Figure 1.11)” [51].

“Experimental results have shown that the channel can transport sodium and potassium ions. The channel can also be constructed by the use of direct covalent bonding between the sheets so as to increase the thermodynamic and kinetic stability” [52].

“By attaching peptides to the octiphenyl scaffold, a β-barrel can be formed via self-assembly through the formation of β-sheet structures between the peptide chains (Figure 1.13)” [53].

“The same scaffold was used by Matile etal. to mimic the structure of macrolide antibiotic amphotericin B. The channel synthesized was shown to transport cations across the membrane” [54].

“Attaching the electron-poor naphthalenediimide (NDIs) to the same octiphenyl scaffold led to the hoop-stave mismatch during self-assembly that results in a twisted and closed channel conformation (Figure 1.14). Adding the compleentary dialkoxynaphthalene (DAN) donor led to the cooperative interactions between NDI and DAN that favors the formation of barrel-stave ion channel.” [57].

MICELLAR

“These aggregate channels are formed by amphotericin involving both sterols and antibiotics arranged in two half-channel sections within the membrane” [58].

“An active form of the compound is the bolaamphiphiles (two-headed amphiphiles). (Figure 1.15) shows an example that forms an active channel structure through dimerization or trimerization within the bilayer membrane. Electrochemical studies had shown that the monomer is inactive and the active form involves dimer or larger aggregates” [60].

ANION CONDUCTING CHANNELS:

“A highly active, anion selective, monomeric cyclodextrin-based ion channel was designed by Madhavan et al (Figure 1.16). Oligoether chains were attached to the primary face of the β-cyclodextrin head group via amide bonds. The hydrophobic oligoether chains were chosen because they are long enough to span the entire lipid bilayer. The channel was able to select “anions over cations” and “discriminate among halide anions in the order I-> Br-> Cl- (following Hofmeister series)” [61].

“The anion selectivity occurred via the ring of ammonium cations being positioned just beside the cyclodextrin head group, which helped to facilitate anion selectivity. Iodide ions were transported the fastest because the activation barrier to enter the hydrophobic channel core is lower for I- compared to either Br- or Cl-“ [62]. “A more specific artificial anion selective ion channel was the chloride selective ion channel synthesized by Gokel. The building block involved a heptapeptide with Proline incorporated (Figure 1.17)” [63].

Cellular Prosthesis: Inklings of a New Interdisciplinary Approach

The paper cites “nanoreactors for catalysis and chemical or biological sensors” and “interdisciplinary uses as nano –filtration membrane, drug or gene delivery vehicles/transporters as well as channel-based antibiotics that may kill bacterial cells preferentially over mammalian cells” as some of the main applications of synthetic ion-channels [65], other than their normative use in elucidating cellular function and operation.

However, I argue that a whole interdisciplinary field and heretofore-unrecognized new approach or sub-field of Functionally-Restorative Medicine is possible through taking the technologies and techniques involved in in constructing, integrating, and experimentally-verifying either a.) non-biological analogues of ion-channels & ion-pumps (thus trans-membrane membrane proteins in general, also sometimes referred to as transport proteins or integral membrane proteins) and membranes (which include normative bilipid membranes, non-lipid membranes and chemically-augmented bilipid membranes), and b.) the artificial synthesis of biological analogues of ion-channels, ion-pumps and membranes, which are structurally and chemically equivalent to naturally-occurring biological components but which are synthesized artificially – and applying such technologies and techniques toward the purpose the gradual replacement of our existing biological neurons constituting our nervous systems – or at least those neuron-populations that comprise the neo- and prefrontal-cortex, and through iterative procedures of gradual replacement thereby achieving indefinite-longevity. There is still work to be done in determining the comparative advantages and disadvantages of various structural and functional (i.e. design) motifs, and in the logistics of implanting the iterative replacement or reconstitution of ion-channels, ion-pumps and sections of neuronal membrane in-vivo.

The conceptual schemes outlined in Concepts for Functional Replication of Biological Neurons [66], Gradual Neuron Replacement for the Preservation of Subjective-Continuity [67] and Wireless Synapses, Artificial Plasticity, and Neuromodulation [68] would constitute variations on the basic approach underlying this proposed, embryonic interdisciplinary field. Certain approaches within the fields of nanomedicine itself, particularly those approaches that constitute the functional emulation of existing cell-types, such as but not limited to Robert Freitas’s conceptual designs for the functional emulation of the red blood cell (a.k.a. erythrocytes, haematids) [69], i.e. the Resperocyte, itself should be seen as falling under the purview of this new approach, although not all approaches to Nanomedicine (diagnostics, drug-delivery and neuroelectronic interfacing) constitute the physical (i.e. electromechanical, kinetic and/or molecular physically-embodied) and functional emulation of biological cells.

The field of functionally-restorative medicine in general (and of nanomedicine in particular) and the field of supramolecular and organic chemistry converge here, where these technological, methodological, and experimental infrastructures developed in field of Synthetic Ion-Channels and Ion Channel Reconstitution can be employed to develop a new interdisciplinary approach that applies the logic of prosthesis to the cellular and cellular-component (i.e. sub-cellular) scale; same tools, new use. These techniques could be used to iteratively replace the components of our neurons as they degrade, or to replace them with more robust systems that are less susceptible to molecular degradation. Instead of repairing the cellular DNA, RNA and protein transcription and synthesis machinery, we bypass it completely by configuring and integrating the neuronal components (ion-channels, ion-pumps and sections of bilipid membrane) directly.

Thus I suggest that theoreticians of nanomedicine look to the large quantity of literature already developed in the emerging fields of synthetic ion-channels and membrane-reconstitution, towards the objective of adapting and applying existing technologies and methodologies to the new purpose of iterative maintenance, upkeep and/or replacement of cellular (and particularly neuronal) constituents with either non-biological analogues or artificially-synthesized-but-chemically/structurally-equivalent biological analogues.

This new sub-field of Synthetic Biology needs a name to differentiate it from the other approaches to Functionally-Restorative Medicine. I suggest the designation ‘cellular prosthesis’.

References:

[1] Williams (1994)., An introduction to the methods available for ion channel reconstitution. in D.C Ogden Microelectrode techniques, The Plymouth workshop edition, CambridgeCompany of Biologists.

[2] Tomich, J., Montal, M. (1996). U.S Patent No. 5,16,890. Washington, DC: U.S. Patent and Trademark Office.

[3] Matile, S., Som, A., & Sorde, N. (2004). Recent synthetic ion channels and pores. Tetrahedron, 60(31), 6405–6435. ISSN 0040–4020, 10.1016/j.tet.2004.05.052. Access: http://www.sciencedirect.com/science/article/pii/S0040402004007690:

[4] XIAO, F., (2009). Synthesis and structural investigations of pyridine-based aromatic foldamers.

[5] Ibid., p. 6411.

[6] Ibid., p. 6416.

[7] Ibid., p. 6413.

[8] Ibid., p. 6412.

[9] Ibid., p. 6414.

[10] Ibid., p. 6425.

[11] Ibid., p. 6427.

[12] Ibid., p. 6416.

[13] Ibid., p. 6419.

[14] Ibid., p. 6419.

[15] Ibid., p. 6419.

[16] Ibid., p. 6419.

[17] Ibid., p. 6419.

[18] Ibid., p. 6421.

[19] Ibid., p. 6422.

[20] Ibid., p. 6422.

[21] Ibid., p. 6422.

[22] Ibid., p. 6422.

[23] Ibid., p. 6423.

[24] Ibid., p. 6423.

[25] Ibid., p. 6423.

[26] Ibid., p. 6426.

[27] Ibid., p. 6426.

[28] Ibid., p. 6427.

[29] Ibid., p. 6327.

[30] Ibid., p. 6427.

[31] XIAO, F. (2009). Synthesis and structural investigations of pyridine-based aromatic foldamers.

[32] Ibid., p. 4.

[33] Ibid., p. 4.

[34] Ibid., p. 4.

[35] Ibid., p. 4.

[36] Ibid., p. 7.

[37] Ibid., p. 8.

[38] Ibid., p. 7.

[39] Ibid., p. 7.

[40] Ibid., p. 7.

[41] Ibid., p. 7.

[42] Ibid., p. 7.

[43] Ibid., p. 8.

[44] Ibid., p. 8.

[45] Ibid., p. 9.

[46] Ibid., p. 9.

[47] Ibid., p. 9.

[48] Ibid., p. 10.

[49] Ibid., p. 10.

[50] Ibid., p. 10.

[51] Ibid., p. 10.

[52] Ibid., p. 11.

[53] Ibid., p. 12.

[54] Ibid., p. 12.

[55] Ibid., p. 12.

[56] Ibid., p. 12.

[57] Ibid., p. 12.

[58] Ibid., p. 13.

[59] Ibid., p. 13.

[60] Ibid., p. 14.

[61] Ibid., p. 14.

[62] Ibid., p. 14.

[63] Ibid., p. 15.

[64] Ibid., p. 15.

[65] Ibid., p. 15.

[66] Cortese, F., (2013). Concepts for Functional Replication of Biological Neurons. The Rational Argumentator. Access: http://www.rationalargumentator.com/index/blog/2013/05/conce…plication/

[67] Cortese, F., (2013). Gradual Neuron Replacement for the Preservation of Subjective-Continuity. The Rational Argumentator. Access: http://www.rationalargumentator.com/index/blog/2013/05/gradu…placement/

[68] Cortese, F., (2013). Wireless Synapses, Artificial Plasticity, and Neuromodulation. The Rational Argumentator. Access: http://www.rationalargumentator.com/index/blog/2013/05/wireless-synapses/

[69] Freitas Jr., R., (1998). “Exploratory Design in Medical Nanotechnology: A Mechanical Artificial Red Cell”. Artificial Cells, Blood Substitutes, and Immobil. Biotech. (26): 411–430. Access: http://www.ncbi.nlm.nih.gov/pubmed/9663339

I was about to discuss the third of three concepts, but thought a look back would be appropriate at this time. In my earlier post I had shown that the photon/particle wave function could not be part of the photon/particle as this would violate the empirical Lorentz-Fitzgerald transformations and therefore, Einstein’s Special Theory of Relativity. The wave function is only the photon/particle’s disturbance of the spacetime it is in, and therefore explains why photons/particles have wave properties. They don’t. They disturb spacetime like a pebble dropped into a pond. The pond’s ripples are not the pebble.

In the recent findings, Dr. Alberto Peruzzo, University of Bristol (UK) the lead author of the paper and quoting “The measurement apparatus detected strong nonlocality, which certified that the photon behaved simultaneously as a wave and a particle in our experiment, … This represents a strong refutation of models in which the photon is either a wave or a particle.” This is a very important finding and another step in the progress of science towards a better understanding of our Universe.

Those of you who have been following my blog posts will recognize that this is empirical validation using single structure test that shows that both wave and particle properties occur together. What is required next, to be empirically rigorous, is to either confirm or deny that this wave function is a spacetime disturbance. For that we require a dual structure test.

If this wave function is a spacetime disturbance, then Einstein’s Special Theory of Relativity is upheld, and we would require a major rethink of quantum physics or the physics of elementary particles. If this wave function is a not spacetime disturbance but part of the particle structure, then there is an empirical exception to the Lorentz-Fitzgerald transformation and we would require a rethink of Einstein’s Special Theory of Relativity.

Here is a proposal for a dual structure test (to test two alternative hypotheses) which probably only an organization like CERN could execute. Is it possible to disturb spacetime in a manner as to exhibit the properties of a known particle but has no mass? That is the underlying elementary particle is not present. I suppose other research institutions could attempt this, too. If successful … it will be a bigger discovery that Dr. Alberto Peruzzo and his team.

My money is on Lorentz-Fitzgerald and Einstein being correct, and I infer that the physics community of quantum and string theorist would not be happy at the possibility of this dual structure test.

So I ask, in the spirit of the Kline Directive, can we as a community of physicists and engineers come together, to explore what others have not, to seek what others will not, to change what others dare not, to make interstellar travel a reality within our lifetimes?

Previous post in the Kline Directive series.

—————————————————————————————————

Benjamin T Solomon is the author & principal investigator of the 12-year study into the theoretical & technological feasibility of gravitation modification, titled An Introduction to Gravity Modification, to achieve interstellar travel in our lifetimes. For more information visit iSETI LLC, Interstellar Space Exploration Technology Initiative.

Solomon is inviting all serious participants to his LinkedIn Group Interstellar Travel & Gravity Modification.

To achieve interstellar travel, the Kline Directive instructs us to be bold, to explore what others have not, to seek what others will not, to change what others dare not. To extend the boundaries of our knowledge, to advocate new methods, techniques and research, to sponsor change not status quo, on 5 fronts, Legal Standing, Safety Awareness, Economic Viability, Theoretical-Empirical Relationships, and Technological Feasibility.

In this post I discuss the second of three concepts, that if implemented should speed up the rate of innovation and discovery so that we can achieve interstellar travel within a time frame of decades, not centuries. Okay, I must remind you that this will probably upset some physicists.

One of the findings of my 12-year study was that gravitational acceleration was independent of the internal structure of a particle, therefore, the elegantly simple formula, g=τc2, for gravitational acceleration. This raised the question, what is the internal structure of a particle? For ‘normal’ matter, the Standard Model suggests that protons and neutrons consist of quarks, or other mass based particles. Electrons and photons are thought to be elementary.

I had a thought, a test for mass as the gravitational source. If ionized matter showed the same gravitational acceleration effects as non-ionized matter, then one could conclude that mass is the source of gravitational acceleration, not quark interaction; because the different ionizations would have different electron mass but the same quark interaction. This would be a difficult test to do correctly because the electric field effects are much greater than gravitational effects.

One could ask, what is the internal structure of a photon? The correct answer is that no one knows. Here is why. In electromagnetism, radio antenna’s specifically, the energy inside the hollow antenna is zero. However, in quantum theory, specifically the nanowire for light photons, the energy inside the nanowire increases towards the center of the nanowire. I’m not going to provide any references as I not criticizing any specific researcher. So which is it?

One could ask the question, at what wavelength does this energy distribution change, from zero (for radio waves) to an increase (for light photons)? Again, this is another example of the mathematics of physics providing correct answers while being inconsistent. So we don’t know.

To investigate further, I borrowed a proposal from two German physicists, I. V. Drozdov and A. A. Stahlhofen, (How long is a photon?) who had suggested that a photon was about half a wavelength long. I thought, why stop there? What if it was an infinitely thin slice? Wait. What was that? An infinitely thin slice! That would be consistent with Einstein’s Special Theory of Relativity! That means if the photon is indeed an infinitely thin pulse, why do we observe the wave function that is inconsistent with Special Theory of Relativity? That anything traveling at the velocity of light must have a thickness of zero, as dictated by the Lorentz-Fitzgerald transformations.

The only consistent answer I could come up with was that the wave function was the photon’s effect or the photon’s disturbance on spacetime, and not the photon itself.

Here is an analogy. Take a garden rake, turn it upside down and place it under a carpet. Move it. What do you see? The carpet exhibits an envelope like wave function that appears to be moving in the direction the garden rake is moving. But the envelope is not moving. It is a bulge that shows up wherever the garden rake is. The rake is moving but not the envelope.

Similarly, the wave function is not moving and therefore spreads across the spacetime where the photon is. Now both are consistent with Einstein’s Special Theory of Relativity. Then why is the Standard Model successful? It is so because just as the bulge is unique to the shape of the garden rake, so are the photon’s and other particles’ wave function disturbances of spacetime are unique to the properties of the photon & respective particles.

In my book, this proposed consistency with Special Theory of Relativity points to the existence of subspace, and a means to achieve interstellar travel.

There are a lot of inconsistencies in our physical theories, and we need to start addressing these inconsistencies if we are to achieve interstellar travel sooner rather than later.

Previous post in the Kline Directive series.

Next post in the Kline Directive series.

—————————————————————————————————

Benjamin T Solomon is the author & principal investigator of the 12-year study into the theoretical & technological feasibility of gravitation modification, titled An Introduction to Gravity Modification, to achieve interstellar travel in our lifetimes. For more information visit iSETI LLC, Interstellar Space Exploration Technology Initiative.

Solomon is inviting all serious participants to his LinkedIn Group Interstellar Travel & Gravity Modification.

I have just watched this video by Global Futures 2045.

This is my list of things I disagree with:

It starts with scary words about how every crisis comes faster and faster. However this is untrue. Many countries have been running deficits for decades. The financial crisis is no surprise. The reason the US has such high energy costs goes back to government decisions made in the 1970s. And many things that used to be crises no longer happen, like the Black Plague. We have big problems, but we’ve also got many resources we’ve built up over the centuries to help. Much of the challenges we face are political and social, not technical.

We will never fall into a new Dark Ages. The biggest problem is that we aren’t advancing as fast as we could and many are still starving, sick, etc. However, it has always been this way. The 20th century was very brutal! But we are advancing and it is mostly known threats like WMDs which could cause a disaster. In the main, the world is getting safer every day as we better understand it.

We aren’t going to build a new human. It is more like a Renaissance. Those who lost limbs will get increasingly better robotic ones, but they will still be humans. The best reason to build a robotic arm is to attach it to a human.

The video had a collectivist and authoritarian perspective when it said:

“The world’s community and leaders should encourage mankind instead of wasting resources on solving momentary problems.”

This sentence needs to be deconstructed:

1. Government acts via force. Government’s job is to maintain civil order, so having it also out there “encouraging” everyone to never waste resources is creepy. Do you want your policeman to also be your nanny? Here is a quote from C.S. Lewis:

“Of all tyrannies, a tyranny sincerely exercised for the good of its victims may be the most oppressive. It would be better to live under robber barons than under omnipotent moral busybodies. The robber baron’s cruelty may sometimes sleep, his cupidity may at some point be satiated; but those who torment us for our own good will torment us without end for they do so with the approval of their own conscience.”

2. It is wrong to think government is the solution to our problems. Most of the problems that exist today like the Greek Debt Crisis, and the US housing crisis were caused by governments trying to do too much.

3. There is no such thing as the world’s leaders. There is the UN, which doesn’t act in a humanitarian crisis until after everyone is dead. In any case, we don’t need the governments to act. We built Wikipedia.

4. “Managing resources” is codeword for socialism. If their goal is to help with the development of new technologies, then the task of managing existing resources is totally unrelated. If your job is to build robots, then your job is not also to worry about whether the water and air are dirty. Any scientist who talks about managing resources is actually a politician. Here is a quote from Frederic Hayek:

“The curious task of economics is to demonstrate to men how little they really know about what they imagine they can design. Before the obvious economic failure of Eastern European socialism, it was widely thought that a centrally planned economy would deliver not only “social justice” but also a more efficient use of economic resources. This notion appears eminently sensible at first glance. But it proves to overlook the fact that the totality of resources that one could employ in such a plan is simply not knowable to anybody, and therefore can hardly be centrally controlled.”

5. We should let individuals decide what to spend their resources on. People don’t only invest in momentary things. People build houses. In fact, if you are looking for an excuse to drink, being poor because you live in a country with 70% taxes is a good one.

The idea of tasking government to finding the solutions and to do all futuristic research and new products to shove down our throats is wrong and dangerous. We want individuals, and collections of them (corporations) to do it because they will best put it to use in ways that actually improve our lives. Everything is voluntary which encourages good customer relationships. The money will be funded towards the products people actually care about, instead of what some mastermind bureaucrat thinks we should spend money on. There are many historical examples of how government doesn’t innovate as well as the private sector: the French telephone system, Cuba, expensive corn-based ethanol, the International Space Station, healthcare. The free market is imperfect but it leads to fastest technological and social progress for the reasons Frederic Hayek has explained. A lot of government research today is wasted because it never gets put to use commercially. There are many things that can be done to make the private sector more vibrant. There are many ways government can do a better job, and all that evidence should be a warning to not use governments to endorse programs with the goal of social justice. NASA has done great things, but it was only because it existed in a modern society that it was possible.

They come up with a nice list of things that humanity can do, but they haven’t listed that the one of the most important first steps is more Linux. We aren’t going to get cool and smart robots, etc. without a lot of good free software first.

The video says:

“What we need is not just another technological revolution, but a new civilization paradigm, we need philosophy and ideology, new ethics, new culture, new psychology.”

It minimizes the technology aspect when this is the hard work by disparate scientists that will bring us the most benefits.

It is true that we need to refine our understandings of many things, but we are not starting over, just evolving. Anyone who thinks we need to start over doesn’t realize what we’ve already built and all the smart people who’ve come before. The basis of good morals from thousands of years ago still apply. It will just be extended to deal with new situations, like cloning. The general rules of math, science, and biology will remain. In many cases, we are going back to the past. The Linux and free software movement is simply returning computer software to the hundreds of years-old tradition of science. Sometimes the idea has already been discovered, but it isn’t widely used yet. It is a social problem, not a technical one.

The repeated use of the word “new”, etc. makes this video like propaganda. Cults try to get people to reset their perspective into a new world, and convince them that only they have the answers. This video comes off as a sales pitch with them as the solution to our problems, ignoring that it will take millions. Their lists of technologies are random. Some of these problems we could have solved years ago, and some we can’t solve for decades, and they mix both examples. It seems they do no know what is coming next given how disorganized they are. They also pick multiple words that are related and so are repeating themselves. Repetition is used to create an emotional impact, another trait of propaganda.

The thing about innovation and the future is that it is surprising. Many futurists get things wrong. If these guys really had the answers, they’d have invented it and made money on it. And compared to some of the tasks, we are like cavemen.

Technology evolves in a stepwise fashion, and so looking at it as some clear end results on some day in the future is wrong.

For another example: the video makes it sound like going beyond Earth and then beyond the Solar System is a two-step process when in fact it is many steps, and the journey is the reward. If they were that smart, they’d endorse the space elevator which is the only cheap way to get out there, and we can do it in 10 years.

The video suggests that humanity doesn’t have a masterplan, when I just explained that you couldn’t make one.

It also suggests that individuals are afraid of change, when in fact, that is a trait characteristic of governments as well. The government class has known for decades that Social Security is going bankrupt, but they’d rather criticize anyone who wants to reform it rather than fix the underlying problem. This video is again trying to urge collectivism with its criticism of the “mistakes” people make. The video is very arrogant at how it looks down at “the masses.” This is another common characteristic of collectivism.

Here is the first description of their contribution:

“We integrate the latest discoveries and developments from the sciences: physics, energetics, aeronautics, bio-engineering, nanotechnology, neurology, cybernetics, cognitive science.”

That sentence is laughable because it is an impossible task. To understand all of the latest advances would involve talking with millions of scientists. If they are doing all this integration work, what have they produced? They want everyone to join up today, work to be specified later.

The challenge for nuclear power is not the science, it is the lawyers who outlawed new ones in 1970s, and basically have halted all advancements in building safer and better ones. Some of these challenges are mostly political, not scientific. We need to get engineers in corporations like GE, supervised by governments, building safer and cleaner nuclear power.

If you wanted to create all of what they offer, you’d have to hire a million different people. If you were building the pyramids, you could get by with most of your workers having one skill, the ability to move heavy things around. However, the topics they list are so big and complicated, I don’t think you could build an organization that could understand it all, let alone build it.

They mention freedom and speak in egalitarian terms, but this is contradicted by their earlier words. In their world, we will all be happy worker bees, working “optimally” for their collective. Beware of masterminds offering to efficiently manage your resources.

I support discussion and debate. I am all for think-tanks and other institutions that hire scientists. However, those that lobby government to act on their behalf are scary. I don’t want every scientist lobbying the government to institute their pet plan, no matter how good it sounds. They will get so overwhelmed that they won’t be able to do their actual job. The rules of the US Federal government are very limited and generally revolve around an army and a currency. Social welfare is supposed to be handled by the states.

Some of their ideas cannot be turned into laws by the US Congress because they don’t have this authority — the States do. Obamacare is likely to be ruled unconstitutional, and their ideas are potentially much more intrusive towards individual liberty. It would require a Constitutional Amendment, which would never pass and we don’t need.

They offer a social network where scientists can plug in and figure out what they need to do. This could also be considered an actual concrete example of something they are working on. However, there are already social networks where people are advancing the future. SourceForge.net is the biggest community of programmers. There is also Github.com with 1,000,000 projects. Sage has a community advancing the state of mathematics.

If they want to create their own new community solving some aspect, that is great, especially if they have money. But the idea that they are going to make it all happen is impossible. And it will never replace all the other great communities that already exist. Even science happens on Facebook, when people chat about their work.

If they want to add value, they need to specialize. Perhaps they come up with millions of dollars and they can do research in specific areas. However, their fundamental research would very likely get used in ways they never imagined by other people. The more fundamental, the more no one team can possibly take advantage of all aspects of the discovery.

They say there is some research lab they’ve got working on cybernetics. However they don’t demonstrate any results. I don’t imagine they can be that much ahead of the rest of the world who provides them the technology they use to do their work. Imagine a competitor to Henry Ford. Could he really build a car much better given the available technology at the time? My response to anyone who has claims of some advancements is: turn it into a demo or useful product and sell it. All this video offer as evidence here is CGI, which any artist can make.

I support the idea of flying cars. First we need driverless cars and cheaper energy. Unless they are a car or airplane company, I don’t see what this organization will have to do with that task. I have nothing against futuristic videos, but they don’t make clear what is their involvement and instances of ambiguity should be noted.

They are wrong when they say we won’t understand consciousness till 2030 because we already understand it at some level today. Neural networks have been around for decades. IBM’s Jeopardy-playing Watson was a good recent example. However, it is proprietary so not much will come of that particular example. Fortunately, Watson was built on lots of free software, and the community will get there. Google is very proprietary with their AI work. Wolfram Alpha is also proprietary. Etc. We’ve got enough the technical people for an amazing world if we can just get them to work together in free software and Python.

The video’s last sentence suggests that spiritual self-development is the new possibility. But people can work on that today. And again, enlightenment is not a destination but a journey.

We are a generation away from immortality unless things greatly change. I think about LibreOffice, cars that drive themselves and the space elevator, but faster progress in biology is also possible as well if people will follow the free software model. The Microsoft-style proprietary development model has infected many fields.

Femtotechnology: AB-Needles. Fantastic properties and Applications

after posting this on facebook.com and seeing its shared on Scribd.com I was a bit shocked by the community of reads in their disregard for these thoughts on Femtotechnology. One reader was quoted to say

I don’t understand why people bother talking about femtotech when we barely even have nanotech…

And while the reader’s voice should be heard, I like to think that if we can imagine it, its worth being a part of the tool box. These ideas are some +50 years in the making and just as nanotech or any other tech this literature predating our abilities is necessary in crafting human kinds exploration. So this entry is a bit activist, and so what smile #fullspeedahead.

Abstract

American history teachers praise the educational value of Billy Joel’s 1980s song ‘We Didn’t Start the Fire’. His song is a homage to the 40 years of historical headlines since his birth in 1949.

Which of Joel’s headlines will be considered the most important a millennium from now?

This column discusses five of the most important, and tries to make the case that three of them will become irrelevant, while one will be remembered for as long as the human race exists (one is uncertain). The five contenders are:

The Bomb
The Pill
African Colonies
Television
Moonshot


Article

My previous column concentrated on the Hall Weather Machine[1], with a fairly technocentric focus. In contrast, this column is not technical at all, but considers the premise that if we don’t know our past, then we don’t know what our future will be.

American history teachers praise Billy Joel’s 1980s song ‘We Didn’t Start the Fire’ for its educational value. His song is a homage to the 40-years of historical headlines since his birth in 1949. Before reading further, go to http://yeli.us/Flash/Fire.html to hear it and to see the photographs that go with each phrase of the song.

Which of Joel’s headlines do you think will be most important, when considered by people a millennium from now? A thousand years is a long time.

Many of the popular figures Joel mentions from politics, entertainment, and sports have already begun to fade from living memory, so they are easy to dismiss. Similarly, which nation won which war will be remembered only by historians, though the genetic components of descendants affected by those wars will reverberate through the centuries. An interesting exercise would consider the most significant events of the eleventh century. English-speaking historians might mention the Battle of Hastings, but is Britain even a world power any longer? Where are the Byzantine, Ottoman, Toltec, and Holy Roman empires of a thousand years ago?

Note that there may be a difference between what most people 1,000 years from now will consider to be the most important and what may actually be the most important. In this case, just because the empires mentioned above are gone doesn’t necessarily mean they didn’t have a significant role in creating our present and our future — we may simply be unconscious of their effect.

I will consider a few possibilities before arguing for one headline that is certain to be remembered, rightfully so, ten thousand years from now — if not longer.


The Bomb

First, most thoughtful people would include the hydrogen-bomb. A few decades ago, almost everyone would have agreed wholeheartedly. At that time, the policy of Mutual Assured Destruction hung heavily over every life in the USSR and the United States (if not the world). With the USSR now gone, and Russia and USA not quite at each others throats, the danger from extinction via a full-out nuclear exchange may be lower. However, the danger of a nuclear attack that kills a few million people is actually more likely.

Up till now, for a nation to become a great power and thereby wield great influence, it needed the level of organization that depended on civilization. No matter how brutal their government or culture — such as Nazi Germany, Communist Soviet Union, or Ancient Rome — their organization depended on efficient education, competent administration, large-scale engineering, and the finer things in life — to motivate at least the elite. Even then, some of the benefit would trickle down as “a rising tide raises all boats”. Competent and educated slaves were a key to Roman Civilization, just as educated bureaucrats were essential to the Nazi and Soviet systems.

Now, however, we are getting into a situation in which atomic weapons give the edge to the stark-raving mad — anyone who is willing to use them. This situation could be most destructive to prosperous, open, humanistic, and civilized nations, because they may be less willing to give up their comfort and freedom to defend against this threat. It appears very likely that within a decade or less, any ragtag collection of pip-squeak lunatics will be able to level the greatest city on Earth, even if it is defended by the world’s strongest army. This is because the advances in nuclear enrichment technology (along with all technology) will make it easier for pip-squeak lunatics to acquire or manufacture nuclear bombs.

That being said, however, it is also true that really advanced technology — specifically privacy-invasive information technology, perhaps in the form of throwaway supercomputers in a massive network of dustcams — might stop the pip-squeak lunatics before they can build and deploy their nuclear bombs.

In addition, another decade of technological development will result in nanobots. By the way, this isn’t just my prediction (the defense of which is a subject of a future column), but also the opinion of inventive dreamers such as Raymond Kurzweil, and of conservative achievers such as Lockheed executives. The development of nanobots means that cellular repair of radiation damage may also become possible (though the problems of controlling trillions of nanobots and of how to detect and repair radiation damage are additional separate and very difficult engineering and biological issues). Michael Flynn examined some of the nuclear strategic issues of this nanotech application in his short story “Washer at the Ford”.[2]

The problem is that there may be a five year window during which our only defense against nuclear-bomb-wielding pip-squeak lunatics will be privacy-invasive information technology, run by the FBI, NSA, and CIA, and their counterparts around the world. Yes, you should be worried, but probably not for the reasons you may think. The danger is not as much that these government agencies may infringe on your rights, but that the very nature of their jobs means that they won’t be able to apply Kranstowitz’s weapon of openness[3] against those who want us dead. To make matters worse, the U.S. intelligence agencies will likely follow the complex laws[3] that protect the privacy of U.S. persons[4] — to the exclusion of catching the nuclear lunatics. This is one reason that FBI, NSA, and CIA directors get new gray hairs every night.

Another problem is that the pip-squeak lunatics will also be able to buy cheap, privacy-invasive information (and other) technologies. Petro-dollars, peasant-made knickknacks, and mining rights have given ethically-challenged individuals in third-world countries astonishing wealth. Many of the world’s richest men live in the world’s poorer countries.[5] They have also learned cruel and clever means by which to keep their peasants down. The question is whether or not they can run the expensive technology they bought with their wealth and power. Buying cheap technology is one thing, but controlling it requires skilled people, and skilled people are more difficult to control. Can the dictators keep a small cadre of trusty elites to run the technology? North Korea and Iran are interesting (and rather scary) test cases at the moment.

Another wild card is that while some dictatorships have become more totalitarian, there comes a point at which the downtrodden peasants (and students, and factory workers, and shopkeepers) don’t have anything to lose but their miserable lives. Meanwhile, totalitarian governments can’t keep up with technology as quickly as free ones can. This is when the system collapses of its own weight, and that is what happened to the USSR. The cell phone, Facebook, and Twitter-fed revolutions in Egypt, Libya, Syria, and elsewhere also seem to prove this point. Thus far, the Chinese leaders have been smart enough to adapt their economy without adapting their government. The jury is still out as to what will happen to them next (it may not be pretty for us if it ends badly, and there are many ways it can end badly).

Another wild card to consider is that most of the existing nuclear warheads are in the United States, Russia, and China. Americans conveniently forget, but non-Americans are very aware that the United States is (thus far) the only nation that has actually used an atomic bomb to kill people. On the other hand, America doesn’t have highly corrupt officials in charge of our nuclear arsenal (Pakistan), nor is it controlled by a near-dictator (Russia), nor by a totalitarian crazed nut-job (North Korea). In addition, a number of important Japanese leaders have publicly said that that controversial decision to bomb Hiroshima and Nagasaki was the correct one–“It could not be helped.“[6] A similar case might be made for Israel, which is surrounded by overwhelming numbers of Arab nations. Given the tensions in the area, a preemptive strike by Israel seems possible, if not likely. The important question then becomes: Under what grounds, if any, could such usage be justified? Of course, Iranian and other Arab leaders have often called for the total destruction of Israel, and eventually one of them may be willing to try it. On what grounds could they be justified?

Another issue is that once we lose New York or some other major city, Americans will accept any solution — including a totalitarian police state. So will the people of other democratic republics if they lose a major city to nuclear terrorists. But the solution is not necessarily a police state. David Brin has answered the “who guards the guardians” question with a clever answer: “We all do.” Over-simplified, his solution is to kiss most of your privacy goodbye. Either that or kiss your life, your liberty, and property, and your privacy all goodbye. Brin proposes that we should all submit to being on camera most of the time — as long as the camera essentially points both ways so we know who is watching us — i.e. the police, our neighbors, the pervert three blocks away, and our governments will know that we are watching them too. We must all shoulder the responsibility of policing our neighborhoods and our governments. The world will be like big village in which everyone knows everyone else’s business, but it’s OK because we are all accountable for our actions. Given the fact that human beings only behave when held accountable, it is the only real solution.[7]

Some may think it naive to expect that governments would ever allow their citizens to observe them in return for their observing us. On the other hand, between the increasing calls for government transparency, and the fact that even the chief of the IMF can be taken down by an lowly maid (with the help of the rule of law), there is hope. Not only that, but many of us have already given away much of our privacy on Facebook and YouTube. Don’t worry about it. Maybe I’m still a wide-eyed optimist, but look at the fall of the USSR empire. Nobody with two brain cells to rub together could have possibly predicted that it could have been so bloodless.

DARPA will certainly look for technological answers for nuclear bomb-related problems such as the nightmare of screening shipping containers. They will probably find some solutions, but during the critical transition phase towards productive nanosystems, will they be able to make those solutions affordable?

One nanotech solution to stopping nuclear bombs that are hidden in shipping containers is to stop all physical shipping altogether and just trade files over the internet, printing whatever you want on our desktops (BTW, you can build a very large printer in two steps). Our only problem then would be keeping our computer virus detectors up to date so that we don’t print something nasty.

To summarize, if anybody is around 1,000 years from now, then the nuclear bomb will not be considered an important issue.


The Pill

The second historically consequential development in the past 50 years that many people will propose as significant is the contraceptive pill.

Some claim that the Pill is necessary because we have a population problem. When I was in college in the 1970’s, it was “proven” to me, with the aid of computer models, that overpopulation was going to be the reason we were going to have food riots in the United States by 1985. So naturally, I’m as skeptical about overpopulation as I am about the imminent rapture. Everyone probably agrees that overpopulation results when the population exceeds the sustainable carrying capacity of the environment. But what determines that capacity? Technology multiplies it while ignorance, injustice, and war decrease it. On Earth today, there is currently no correlation between standard of living and population density.[8]

That being said, in a closed system, unlimited human population growth could result in a situation worse than simple human extinction. Natural ecosystems have population boom/crash cycles all the time, but other species don’t have access to nuclear bombs and other devices that can obliterate habitats. The overpopulation disaster on Easter Island occurred with a primitive culture. It still has grass, but not much of an ecosystem. Imagine what could have happened with modern technology.

The Pill fundamentally changed the relationship of men and women, the place of children in a family and, on the macro level, population dynamics. The family is the basic building block of society and civilization, not only because it is an economic unit (you don’t pay your spouse to wash the dishes or take out the garbage), but more importantly, because the family critically shapes the next generation. Therefore, a large change in family structures will have far-reaching effects, at least in the “short run” of five to ten generations. However, to steal from Jerry Pournell and Larry Niven: “Think of it as evolution in action.“[9] The people who embrace contraception as a path to “the good life” will (evolutionarily speaking) remove their vote for influencing their future within a few generations. It is true that for humans, memes may carry as much weight as genes, but the same process applies — as long as meme propagation is kept below a critical level, perhaps by co-traveling xenophobic memes. On the other hand, people who don’t have much of their material resources tied up in children may have more time to devote to meme propagation. However, many studies have shown than the people who have the greatest impact on teens and pre-teens are their parents.[10]

One possible result is that a millennium from now, the Pill will be a small blip, as inconsequential as the Shakers, and for essentially similar reasons. Nanotechnology-enabled life extension techniques will extend that blip for a while, but because the prolific pro-natalists will continue having even more children for their longer lives, more pro-natalists will be born to outvote the anti-natalists. This is why the Jewish Knesset now has a significantly higher percentage of Ultra-Orthodox than when it began,[11] why Utah’s government is almost 100% Mormon,[12] and why the Amish are one of the fastest growing minority in the world, with an average of 6.8 children per family.[13]

The opposing trend is controlled by a number of factors. First, the birth rate goes down as women’s educations go up. This occurs partially because practically speaking, it is more difficult to go to school while being married and raising children. More subtly, however, it is because school is an investment in learning a professional trade — it is a different investment than children. In addition, women and men are implicitly and explicitly taught that a better career is more important than raising more children.

The problem isn’t that women are being educated. The problem is that if they are taught something that results in the extinction of our egalitarian, humanistic, and liberal society by one that is misogynistic, xenophobic, and unjust, then something is wrong.

One weapon of the contraceptive culture is the reeducation of the pro-natalist’s children. Proponents of secularization would call this “giving people free access to all information” not “reeducation”. But when Bibles are banned from the classroom, and students are taught in many ways that they are just animals, it seems like imposition of a secular viewpoint. At least they could teach the debate — and at the end of the semester, the students could try to guess the teacher’s bias (if they can’t, then the teacher presented both views with equal force).

There are more than a million home-schooled children in the U.S., up to two-thirds of whom are there primarily because their parents fear the imposition of our government’s ideas on their children.[14] This quiet protest is so feared by governments that parents are prosecuted for doing this, not only in all totalitarian countries but even in some democratic nations.[15] The alternative is that the governments of open, liberal, and secularized nations (that accept contraception) will decide that the vote of the increasing minority is wrong. Could their right to vote be taken away? Of course it can; it has happened before.

A pessimistic view of this possibility of disenfranchisement is also supported by the prevalence of abortion in liberal democracies. Given the accuracy of ultrasound imagery, if we can ignore the right to life for our most innocent and helpless, then how safe is something as meager as the right to vote? Niemöller’s poem about trade unionists, Communists, and Catholics comes to mind.[16] So do the events in ancient Egypt, during the three or four hundred years between the famines that Joseph ameliorated (Genesis 50:22). The Egyptian upper class used contraception[17], and they felt threatened by the increasing numerical growth of the Jews, who had strict injunctions against it.

Is it good for our country that more than a million children are being taught by their parents? What if rebellious parents are teaching strange and dangerous ideas? How do we decide which ideas are dangerous? Do we censor and suppress them? After all, ideas have consequences.

The answer is that there are limits to what parents can do, but very few — if any — on what they teach. The whole point about freedom of religion is that we can believe what we want, as long as we do not destroy society or individuals with our actions. Our constitution was written not to limit individuals, but to put strict limits on government, since it is inherently more powerful.

The temptation to avoid having children is not limited to any particular culture. The reason is simple: raising children is an expensive, risky, and difficult investment. Parents must be willing to give up fancy vacations, luxury cars, time to themselves, a good night’s sleep, stress on their marriage, and many other things, thus weighing against the pro-natalist agenda. However, the culture that teaches that children are a blessing and a worthwhile investment instead of a cost will overcome those that do not — even if it tends to encourage people to be ignorant, misogynist, racist, and illogical (like two polygamist religions that start with the letter “M“[18]).

Cyril M. Kornbluth’s 1951 short story “The Marching Morons” illustrates another potential downside to the anti/pro-natalist issue by portraying a scenario in which selective pressure resulted in smart people breeding themselves out of existence. It also, despite the derogatory title, provides a warning: the originator of the “Final Solution” (placing all the fertile morons onto one-way rockets to nowhere) ends up screaming futilely as he himself is loaded on one of the last rockets. Kornbluth’s main premise seems logical. People are often willing to trade children for the better material things and higher standard of living, and those with more education are more willing to do so. But is the resulting cost to society worth it?

What will happen when productive nanosystems and advanced software lowers the price of goods and services to very low levels? Many other things will happen at the same time, but in a society of economic abundance, the expense of children will drop significantly — and will be limited only by attention span and desire (and possibly expanded by reproductive-enhancing technologies including parthenogenesis and male pregnancy). Is there a gene for liking children? Or is it a meme that is culturally transmitted? Evolution favors both. Of course, evolution may also favor a “Boys from Brazil“[19] scenario (in which numerous clones of a dictator are grown to reinstate his rule). This strategy may be successful as long as the clones survive to adulthood and can reproduce.

While a contraceptive culture is non-sustainable, especially in the face of a competing culture whose population is growing, it must be noted that a pro-natalist culture is also non-sustainable. Isaac Asimov pointed out that even if we could overcome all technological obstacles, any growth rate will eventually result in humanity becoming a big ball of flesh, expanding at the speed of light (BOFESOL, or BOF for short). At a modest 3% rate, we will reach the initial BOF in only 3,584 years. After that, the speed of light will limit growth.

However, the fact that a contraceptive culture is non-sustainable in a significantly shorter term than the pro-natalist one is why it makes sense for governments to support traditional religions in their efforts to maintain traditional morality and fertility. The difficult problem is finding ways to ensure the survival of a culture without it becoming xenophobic. This is difficult to do when we think that we have Absolute Truth and the One True Religion on our side. But then exactly how do we know that our particular set and ordering of values is the objectively correct one? Note that the denial of the existence of any objectively maximum set of values exists is itself a particular set of values. And note also that sustainability and tolerance are also values that, like all values, must be assumed because they cannot be proven.

Given the contradictory evidence and shifting values, it is likely that equilibrium between pro-natalist and contraceptive meme sets can never be reached. Instead, humanity will likely experience benign (and sometimes not-so benign) boom and crash cycles similar to those that natural ecosystems suffer from. Only for us, our cycles will be constrained by opinions and technological capabilities, not by predators.


African Colonies

A third historical event that may be of consequence a thousand years from now is “Belgians in the Congo”. The Belgian regime in the Congo was about as brutal and inhuman as any the Europeans imposed on its colonies. However, the European Empires spread Christianity in Africa — where it remains a fast-growing religion. This African event may be as significant as when the Spanish and Portuguese spread Christianity in Latin America, and will bring about a fundamentally different world than if Africa had gone Islamic, Hindu, or Confucian. Think of Latin American worshiping the Aztec gods with human sacrifice, or the impact on us if it were an Islamic Civilization. We would live in a very different world.

Then again, Africa may still turn Islamic. After all, Islam generally values large families, just like the fast-growing Mormon and Amish religions do. On the other hand, when Muslims become secularized, they reduce the number of their offspring, just like secularized Christians do — hence their accompanying philosophies will suffer the same fate. The result will be that in order to survive in the long term, future generations must be hostile to secularization, and probably hostile to each other’s religious views also (not a pleasant thought, even if they do share many of the same values). Over the next thousand years, in view of the exponential increase in technological power, which viewpoint will win? The answer depends on science, theology, and demographics.

A handful of nominal Christians destroyed the Aztec civilization, not because of their technology (though that helped), but because the Aztec civilization was based on a great and powerful falsehood — that in order for the sun to rise every morning, human blood needed to be shed — thereby earning the hatred of the neighboring tribes whose blood it was that was usually shed. Islam is not as false as the Aztec religion — otherwise it would not have lasted this long. But the jury is still out on whether it can survive the extreme technological advancement that productive nanosystems will bring. Will fanatical Muslims be able to design and build the nanotech equivalent of 747 jets that they can fly into the skyscrapers of their enemies? Or will they just learn how to use it in unexpected and terrorizing ways? Given the high level of technological advancement in the Muslim empire a thousand years ago, the answer seems to be “yes” to both questions. However, Islam’s ultimate rejection of reason is its Achilles heel, and in the past it helped lead to the decline of the Ottoman Empire after its peak in the 1300s. This is because Islam’s idea of Allah’s absolute transcendence is incompatible with the idea that the universe is ordered and knowable. Psychologically, the problem is that if the universe is not ordered and knowable, then why bother learning and doing science? Meanwhile, Hinduism has many competing gods, and this leads (like in ordinary paganism) to its rejection of the logical principle of contradiction — without which science is impossible. Confucianism seems to be more a moral code than a religious one, so it seems that it could be accommodating to technology — but that didn’t seem to help its practitioners develop it before they collided with the West. Similarly with Buddhism. Meanwhile, the decadent West’s deconstructionism and nihilism is gnawing at its parent’s roots, rejecting reason and science as merely tools of power.

It can be claimed that religious views will keep changing and splitting into new orthodoxies. In that case, the result will be an ever-shifting field of populations and sub-populations with none winning out completely over the others. But as far as I can tell, neither Judaism, Catholicism, Buddhism, nor Islam have changed any of their core beliefs in the past few millennia. In contrast, the Mormons have changed a number of their major doctrines, and so have the Protestants. This does not bode well for their long-term survival as a coherent organization, though the Mormons do have their high fertility on their side.

At the moment, the whole world is copying the Christian-rooted West, as many of their scientific elite are educated in Europe and the United States. It is difficult to say to what extent they understand the philosophical underpinnings of science. When their own universities start to educate their elite, their cultural assumptions will probably displace the Judeo-Christian/Greek philosophy of the West. Then what? It depends if science, which is the foundation of technological superiority, is simply a cargo cult that works. My claim is that science will only continue working for more than a generation or two if its underlying assumptions come with it — that the universe is both ordered and knowable.

These Judeo-Christian assumptions are huge — though atheists, agnostics, and (maybe) Muslims and Buddhists should also be able to accept them. However, every scientist still faces the question of why the universe is ordered and knowable (and if you’re not constantly asking the next question, especially the “why” question, then you’re not a very good scientist). The theistic answer of design by creator[20] is not too far away from the assumption of an ordered and knowable universe, and from there, one begins skating very close to the concept that we are made “Imago Dei”–in God’s image. Some people think that there is too much hubris and ego to that belief, but you don’t see dolphins landing on the Moon, or chimpanzees creating great symphonies (or even bad rap).

“Imago Dei” is the most logical conclusion once we can explain why the universe is predictable and knowable. And being made in God’s image has other implications, especially in terms of our role in this universe. Most notably, it promotes the idea of human beings as powerful stewards of creation, as opposed to subservient subjects of Mother Nature, and it will pit Nietzschean Transhumanists and Traditional Catholics against Gaian environmentalists and National Park Rangers.


Television

Writing has been around for thousands of years, while the printing press has been around for almost 600. It would seem that the printing press was the one invention that, more than anything else, enabled the development of all subsequent inventions. Television could be considered an improvement over writing, and given that large amounts of video can be subject to slightly less interpretation than an equal amount of effort writing text, our descendants might get a better, more complete depiction of history than they could get from just text or physical artifacts. However, the television that Joel mentioned was controlled by the big three television networks. This was because the cost to entry was so high (currently from $200,000 to $13 million per episode). So the role of television of the 1960s was similar to the role of books in Medieval Europe, where the cost of a book was equivalent to the yearly salary of a well-educated person). For this reason, Joel’s headline will not be considered significant, though he was close.

He was close because television’s electronic video display offspring, the computer — especially when connected to form the Internet — will certainly be significant. It will be as significant as the nuclear bomb and the Pill combined, if and when Moore’s Law ushers in the Singularity. But Joel was writing a song, not engaging in future studies. We might as well criticize him for not mentioning the coining of the word “nanotechnology”.


Moonshot

A few of Billy Joel’s headlines may be remembered 1,000 years from now, but none mentioned so far will really be significant.

I would go out on a limb and say that other than the scientific and industrial revolutions, the American Constitution, and the virtual abolishment of slavery, little of consequence has happened in the last thousand years. There is, however, one significant event that happened in the 1400s. No, it’s not Spain kicking out the Muslims. It’s not even Admiral Zheng He, Admiral of China’s famed Dragon Fleet, sailing to Africa in the 1420s, though we’re getting warmer. As impressive as they were, Zheng’s voyages did not change the world. What did change the world was the tiny fleet of three ships that returned from the New World to Spain in 1492.

Apollo and Star Trek both pointed to the next and final frontier. It is true that little has happened in the American space program since Apollo, and with the retirement of the 1960s-designed Space Shuttle, even less is expected. This poor showing has occurred because the moon shot, as awe-inspiring as it was, was a political stunt funded for political reasons. The problem is that it didn’t pay for itself, and we therefore have a dismal space program. However, with communication, weather, and GPS satellites, we have a huge space industry. It’s all about the value added.

On the other hand, it’s the governmental space programs that seem to make the initial (and necessary) investments in the basic technology. More importantly, these programs give voice to that which makes us human — “to look at the stars and wonder”.[21]

Realistically, looking at the historical records of Jamestown and Salt Lake City, space development will occur when prosperous upper class families can sell their homes and businesses to buy a one-way ticket and homesteading tools. In today’s money, that would be about one or two million dollars. We have a long way to go to achieve that price break, though it helps that Moore’s Law is exponential.

There have only been a dozen men on the Moon so far, but Neil Armstrong will be remembered far longer than anyone else in this millennium. After the human race has spread throughout the solar system, and after it starts heading for the stars, everyone will remember who took the first small step. The importance of this step will become obvious after the Google Moon prize is won, and after Elon Musk and his imitators demonstrate conclusively that we are no longer in a zero sum game.

That is something to look forward to.

Tihamer Toth-Fejel is Research Engineer at Novii Systems.


Acknowledgments

Many thanks to Andrew Balet, Bill Bogen, Tim Wright, and Ted Reynolds for their significant contributions to this column.


Footnotes

1. Tihamer Toth-Fejel, The Politics and Ethics of the Hall Weather Machine, https://lifeboat.com/blog/2010/09/the-politics-and-ethics-of…er-machine and http://www.nanotech-now.com/columns/?article=486
2. Michael Flynn, Washer at the Ford, Analog, v109 #6 & 7, June & July 1989.
3. Arthur Kantrowitz, The Weapon of Openness, http://www.foresight.org/Updates/Background4.html
4. United States Signals Intelligence Directive 18, 27 July 1993, http://cryptome.org/nsa-ussid18.htm
5. e.g. Mexico, India, Saudia Arabia, and Russia http://www.forbes.com/lists/2010/10/billionaires-2010_The-Wo…_Rank.html Also, the petro-dollar millionaires in the Mideast http://www.aneki.com/millionaire_density.html
6. There is an interesting discussion at http://en.wikipedia.org/wiki/Debate_over_the_atomic_bombings…d_Nagasaki
7. David Brin,The Transparent Society, Basic Books (1999). For a quick introduction, see The Transparent Society and Other Articles about Transparency and Privacy, http://www.davidbrin.com/transparent.htm.
8. Tihamer Toth-Fejel, Population Control, Molecular Nanotechnology, and the High Frontier, The Assembler, Volume 5, Number 1 & 2, 1997 http://www.islandone.org/MMSG/9701_05.html#_Toc394339700
9. Larry Niven and Jerry Pournelle, Oath of Fealty. New York : Pocket Books, 1982
10. KIDS COUNT Indicator Brief, Reducing the Teen Birth Rate, July 2009. http://www.aecf.org/~/media/Pubs/Initiatives/KIDS%20COUNT/K/…0brief.pdf
11. From a small group of just four members in the 1977 Knesset, they gradually increased their representation to 22 (out of 120) in 1999 (http://en.wikipedia.org/wiki/Haredi_Judaism). The fertility rate for ultra-Orthodox mothers greatly exceeds that of the Israeli Jewish population at large, averaging 6.5 children per mother in the ultra-Orthodox community compared to 2.6 among Israeli Jews overall (http://www.forward.com/articles/7641/ ).
12. As of mid-2001, the Governor of Utah, and all of its Federal senators, representatives and members of the Supreme Court are all Mormon. http://www.religioustolerance.org/lds_hist1.htm
13. Julia A. Ericksen; Eugene P. Ericksen, John A. Hostetler, Gertrude E. Huntington. “Fertility Patterns and Trends among the Old Order Amish”. Population Studies (33): 255–76 (July 1979).
14. 1.1 Million Homeschooled Students in the United States in 2003. http://nces.ed.gov/nhes/homeschool/
15. HOMESCHOOLING: Prosecution is waged abroad; troubling trends abound in US http://www.bpnews.net/BPnews.asp?ID=34699
16. http://timpanogos.wordpress.com/2010/02/26/quote-of-the-mome…speak-out/
17. http://www.patentex.com/about_contraception/journey.php
18. I should note that almost all of the people I have personally known from these two religions are trustworthy, intelligent, and a pleasure to meet. Despite what they are taught in their sacred texts.
19. Ira Levin, Boys from Brazil, Dell (1977)
20. There are many question to follow. How did He do it? Why is He masculine? Why did He do it? How do we know? That last question is especially relevant.
21. Guy J. Consolmagno, Brother Astronomer: Adventures of a Vatican Scientist, McGraw-Hill (2001)