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Nanospears deliver genetic material to cells with pinpoint accuracy

UCLA scientists have developed a new method that utilizes microscopic splinter-like structures called “nanospears” for the targeted delivery of biomolecules such as genes straight to patient cells. These magnetically guided nanostructures could enable gene therapies that are safer, faster and more cost-effective.

The research was published in the journal ACS Nano by senior author Paul Weiss, UC Presidential Chair and distinguished professor of chemistry and biochemistry, materials science and engineering, and member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.

Gene therapy, the process of adding or replacing missing or defective genes in patient cells, has shown great promise as a treatment for a host of diseases, including hemophilia, muscular dystrophy, immune deficiencies and certain types of cancer.

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Scientists zap tiny wires with lasers to create mini-nuclear fusion

A step towards limitless energy? reactions at record efficiency…


Researchers from Colorado State University’s (CSU) Advanced Beam Laboratory used a compact but powerful laser they built from scratch to heat tiny, invisible wires, known as nanowires.

These contained a source of deuterium, one of two stable isotopes of hydrogen and a common source of fuel for nuclear fusion reactions.

The experiment resulted in a chain reaction of fusion events, which created a hot and dense plasma containing helium and highly energetic neutrons.

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Proposed ‘Nanomechanical’ Computer is Both Old-School and Cutting-Edge

A group of engineers have proposed a novel approach to computing: computers made of billionth-of-a-meter-sized mechanical elements. Their idea combines the modern field of nanoscience with the mechanical engineering principles used to design the earliest computers.

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Nanowire-zapping lasers unlock micro-scale nuclear fusion efficiency record

Researchers at Colorado State University (CSU) have broken the efficiency record for nuclear fusion on the micro-scale. Using an ultra-fast, high-powered tabletop laser, the team’s results were about 500 times more efficient than previous experiments. The key to that success is the target material: instead of a flat piece of polymer, the researchers blasted arrays of nanowires to create incredibly hot, dense plasmas.

We have nuclear fusion to thank for our very existence – without it, the Sun wouldn’t have fired up in the first place. Inside that inferno, hydrogen atoms are crushed and through a series of chain reactions, eventually form helium. In the process, tremendous amounts of energy are released. Theoretically, if we can harness that phenomenon we could produce an essentially unlimited supply of clean energy, and although breakthroughs have been made in recent years, nuclear fusion energy remains tantalizingly out of reach.

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New synthetic polymer kills antibiotic-resistant superbugs from the inside out

A research team composed of scientists from the Institute of Bioengineering and Nanotechnology (IBN) of the Agency for Science, Technology and Research (A*STAR) and IBM Research has produced a new synthetic molecule that can target and kill five multidrug-resistant bacteria. This synthetic polymer was found to be non-toxic and could enable entirely new classes of therapeutics to address the growing problem of antibiotic-resistant superbugs.

The synthetic molecules are called guanidinium-functionalized polycarbonates and were found to be both biodegradable and non-toxic to human cells. Essentially, the positively-charged synthetic polymer enters a living body and binds specifically to certain bacteria cells by homing in on a microbial membrane’s related negative charge. Once attached to the bacteria, the polymer crosses the cell membrane and triggers the solidification of proteins and DNA in the cell, killing the bacteria.

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Revolutionary Eye-drops Developed

Eye-drops that can repair the corneas and can improve the short and long sightedness have been developed by a team of Ophthalmologists at Shaare Zedek Medical Center and Bar-Ilan University’s Institute of Nanotechnology and Advanced Materials. The solution of nanoparticles called the ‘nanodrops’ was successfully tested on a pig’s cornea. Clinical trials are expected to be carried out later this year. If the clinical trials on humans are successful, it is expected that the need of eyeglasses will be eliminated.

The leader of the research team, Dr. David Smadja, said that the eye-drops can bring a revolution in ophthalmological and optometry treatment of patients who are suffering from myopia, hyperopia and other refractory conditions. The revolutionary breakthrough in the field was revealed by Dr. Smadja at Shaare Zedek’s second biennial research day, which was held at Steinberg Auditorium in Jerusalem. He said that the nano drops can also be used to replace multifocal lenses and allow people to see objects from different distances. Smadja said, “This is a new concept for correcting refractory problems.” However, he didn’t mention the times of applications which will replace the need for the glasses completely.

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Modified, 3D-printable alloy shows promise for flexible electronics, soft robots

Researchers in Oregon State University’s College of Engineering have taken a key step toward the rapid manufacture of flexible computer screens and other stretchable electronic devices, including soft robots.

The advance by a team within the college’s Collaborative Robotics and Intelligent Systems Institute paves the way toward the 3D printing of tall, complicated structures with a highly conductive gallium alloy.

Researchers put nickel nanoparticles into the , galinstan, to thicken it into a paste with a consistency suitable for .

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Can Earth be hacked by aliens? Scientists say messages from space could destroy life as we know it

The researchers also suggested that aliens could “gift” us with an artificial intelligence (AI) system that may trick humans into developing self-replicating nanobots and eventually deploy them to wreak havoc on our planet. The researchers argue that it would be cheaper for aliens to “send a malicious message to eradicate humans compared to sending battleships”.

In one scenario, the researchers argued that a message from aliens could be a panic-inducing statement like “We will make your sun go supernova tomorrow”. According to the researchers, if such a threatening message is received in just one location, it may be possible to contain and even destroy it. “If it is received repeatedly, perhaps even by amateurs, containment is impossible,” the researchers wrote in a paper available online on arXiv.

In another scenario, the scientists argue that humans could be tricked into begetting their own demise by aliens offering the “gift” of knowledge. For instance, aliens could transmit a message that reads: “We are friends. The galactic library is attached. It is in the form of an artificial intelligence (AI) which quickly learns your language and will answer your questions. You may execute the code following these instructions…”

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New technique allows printing of flexible, stretchable silver nanowire circuits

Researchers at North Carolina State University have developed a new technique that allows them to print circuits on flexible, stretchable substrates using silver nanowires. The advance makes it possible to integrate the material into a wide array of electronic devices.

Silver nanowires have drawn significant interest in recent years for use in many applications, ranging from prosthetic devices to wearable health sensors, due to their flexibility, stretchability and conductive properties. While proof-of-concept experiments have been promising, there have been significant challenges to printing highly integrated using silver nanowires.

Silver nanoparticles can be used to print circuits, but the nanoparticles produce circuits that are more brittle and less conductive than silver nanowires. But conventional techniques for printing circuits don’t work well with silver nanowires; the nanowires often clog the printing nozzles.

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