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Category: nanotechnology – Page 28

The spliceosome: An atomic-level look into how cells avoid errors when manufacturing mRNA

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing is a basic requirement for producing proteins that fulfill an organism’s vital functions. Faulty functioning of a spliceosome can lead to a variety of serious diseases.

Researchers at the Heidelberg University Biochemistry Center (BZH) have succeeded for the first time in depicting a faulty “blocked” at high resolution and reconstructing how it is recognized and eliminated in the cell. The research was published in Nature Structural & Molecular Biology.

The of all living organisms is contained in DNA, with the majority of genes in higher organisms being structured in a mosaic-like manner. So the cells are able to “read” the instructions for building proteins stored in these genetic mosaic particles, they are first copied into precursors of mRNA, or messenger RNA. The spliceosome then converts them into mature, functional mRNA.

New laser technology that scans a face half-a-mile away developed

LiDAR, or Light Detection and Ranging, works by measuring the time it takes for a laser pulse to travel to an object and back. This time-of-flight measurement reveals the distance, and by scanning across an area, a 3D image is created.

This new tech utilizes a superconducting nanowire single-photon detector (SNSPD), an ultrasensitive detector developed by the MIT and NASA Jet Propulsion Laboratory.

Nature research paper: Emergence of collective oscillations in massive human crowds

Dense crowds form some of the most dangerous environments in modern society. Dangers arise from uncontrolled collective motions, leading to compression against walls, suffocation and fatalities. Our current understanding of crowd dynamics primarily relies on heuristic collision models, which effectively capture the behaviour observed in small groups of people. However, the emergent dynamics of dense crowds, composed of thousands of individuals, remains a formidable many-body problem lacking quantitative experimental characterization and explanations rooted in first principles. Here we analyse the dynamics of thousands of densely packed individuals at the San Fermín festival (Spain) and infer a physical theory of dense crowds in confinement. Our measurements reveal that dense crowds can self-organize into macroscopic chiral oscillators, coordinating the orbital motion of hundreds of individuals without external guidance. Guided by these measurements and symmetry principles, we construct a mechanical model of dense-crowd motion. Our model demonstrates that emergent odd frictional forces drive a non-reciprocal phase transition7 towards collective chiral oscillations, capturing all our experimental observations. To test the robustness of our findings, we show that similar chiral dynamics emerged at the onset of the 2010 Love Parade disaster and propose a protocol that could help anticipate these previously unpredictable dynamics.

International collaboration sheds new light on the relationship between quantum theory and thermodynamics

Researchers from Nagoya University in Japan and the Slovak Academy of Sciences have unveiled new insights into the interplay between quantum theory and thermodynamics. The team demonstrated that while quantum theory does not inherently forbid violations of the second law of thermodynamics, quantum processes may be implemented without actually breaching the law.

This discovery, published in npj Quantum Information, highlights a harmonious coexistence between the two fields, despite their logical independence. Their findings open up new avenues for understanding the thermodynamic boundaries of quantum technologies, such as and nanoscale engines.

This breakthrough contributes to the long-standing exploration of the second law of thermodynamics, a principle often regarded as one of the most profound and enigmatic in physics.

Revolutionary Laser Propulsion: Caltech’s New Lightsail Innovation Promises Stellar Journeys

Discover how Caltech’s groundbreaking research on ultrathin light sails is revolutionizing space travel. This video explains the innovative design, precise measurements, and surprising discoveries that are paving the way for interstellar propulsion. Dive into the science behind using laser-driven membranes to propel spacecraft and learn why this breakthrough is a game-changer for future space exploration.

Paper link: https://www.nature.com/articles/s4156… 00:00 Introduction 00:57 Experimental Innovations in Lightsail Design 03:56 Precision Measurement of Radiation Pressure 07:37 Future Directions, Implications, and a Relevant Discovery 11:06 Outro 11:16 Enjoy MUSIC TITLE: Starlight Harmonies MUSIC LINK: https://pixabay.com/music/pulses-star… Visit our website for up-to-the-minute updates: www.nasaspacenews.com Follow us Facebook: / nasaspacenews Twitter: / spacenewsnasa Join this channel to get access to these perks: / @nasaspacenewsagency #NSN #NASA #Astronomy#InterstellarLightsail #Caltech #SpaceExploration #BreakthroughStarshot #LaserPropulsion #Nanotechnology #SpaceTech #InterstellarTravel #LightsailDesign #Physics #Astrophysics #SpaceInnovation #RocketScience #FutureTech #LaserSail #PhotonPropulsion #SciTech #SpaceResearch #Astronomy #Innovation #ScienceNews #Interstellar #SpaceMission #LabResearch #Nanofabrication #EdgeScattering #RadiationPressure #Metamaterials #SpaceExplorationNews #NextGenTech.

Chapters:
00:00 Introduction.
00:57 Experimental Innovations in Lightsail Design.
03:56 Precision Measurement of Radiation Pressure.
07:37 Future Directions, Implications, and a Relevant Discovery.
11:06 Outro.
11:16 Enjoy.

MUSIC TITLE: Starlight Harmonies.
MUSIC LINK: https://pixabay.com/music/pulses-star…

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www.nasaspacenews.com.

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Proposed solution could bring DNA-nanoparticles motors up to speed with motor proteins

DNA-nanoparticle motors are exactly as they sound: tiny artificial motors that use the structures of DNA and RNA to propel motion through enzymatic RNA degradation. Essentially, chemical energy is converted into mechanical motion by biasing the Brownian motion.

The DNA-nanoparticle motor uses the “burnt-bridge” Brownian ratchet mechanism. In this type of movement, the motor is propelled by the degradation (or “burning”) of the bonds (or “bridges”) it crosses along the substrate, essentially biasing its motion forward.

These nano-sized motors are highly programmable and can be designed for use in molecular computation, diagnostics, and transport.

Production of novel theranostic nano-vector based on superparamagnetic iron oxide nanoparticles/miR-497 targeting colorectal cancer

Colorectal cancer (CRC) is a serious public health concern worldwide. Immune checkpoint inhibition medication is likely to remain a crucial part of CRC clinical management. This study aims to create new super paramagnetic iron oxide nano-carrier (SPION) that can effectively transport miRNA to specific CRC cell lines. In addition, evaluate the efficiency of this nano-formulation as a therapeutic candidate for CRC. Bioinformatics tools were used to select a promising tumor suppressor miRNA (mir-497-5p). Green route, using Fusarium oxyporium fungal species, manipulated for the synthesis of SPION@Ag@Cs nanocomposite as a carrier of miR-497-5p. That specifically targets the suppression of PD1/PDL1 and CTLA4pathways for colorectal therapy. UV/visible and FTIR spectroscopy, Zeta potential and MTT were used to confirm the allocation of the miR-497 on SPION@Ag@Cs and its cytotoxicity against CRC cell lines. Immunofluorescence was employed to confirm transfection of cells with miR-497@NPs, and the down-regulation of CTLA4 in HT29, and Caco2 cell lines. On the other hand, PDL1 showed a significant increase in colorectal cell lines (HT-29 and Caco-2) in response to mir497-5p@Nano treatment. The data suggest that the mir-497-loaded SPION@Ag@Cs nano-formulation could be a good candidate for the suppression of CTLA4in CRC human cell lines. Consequently, the targeting miR-497/CTLA4 axis is a potential immunotherapy treatment strategy for CRC.

Elfiky, A.M., Eid, M.M., El-Manawaty, M. et al. Sci Rep 15, 4,247 (2025). https://doi.org/10.1038/s41598-025-88165-3

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Electrically Controlled Nanogate Revolutionizes Molecular Movement

Scientists at Osaka University have designed a nanogate that opens and closes using electrical signals, offering precise control over ions and molecules.

This tiny innovation has the potential to transform sensing technology, chemical reactions, and even computing. By adjusting voltage, researchers can manipulate the gate’s behavior, making it a versatile tool for cutting-edge applications.

Nanogates: control at the macro and nanoscale.

Multidimensional sampling theory reduces noise to push flat optics boundaries

A research team at POSTECH has developed a novel multidimensional sampling theory to overcome the limitations of flat optics. Their study not only identifies the constraints of conventional sampling theories in metasurface design but also presents an innovative anti-aliasing strategy that significantly enhances optical performance. Their findings were published in Nature Communications.

Flat optics is a cutting-edge technology that manipulates light at the nanoscale by patterning ultra-thin surfaces with nanostructures. Unlike traditional optical systems that rely on bulky lenses and mirrors, enables ultra-compact, high-performance optical devices. This innovation is particularly crucial in miniaturizing smartphone cameras (reducing the “camera bump”) and advancing AR/VR technologies.

Metasurfaces, one of the most promising applications of flat optics, rely on hundreds of millions of nanostructures to precisely sample and control the phase distribution of light. Sampling, in this context, refers to the process of converting analog optical signals into discrete data points—similar to how the human brain processes visual information by rapidly capturing multiple images per second to create continuous motion perception.