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New nanocavities pave the way for enhanced nanoscale lasers and LEDs that could enable faster data transmission using smaller, more energy-efficient devices.

As we transition to a new era in computing, there is a need for new devices that integrate electronic and photonic functionalities at the nanoscale while enhancing the interaction between photons and electrons. In an important step toward fulfilling this need, researchers have developed a new III-V semiconductor nanocavity that confines light at levels below the so-called diffraction limit.

“Nanocavities with ultrasmall mode volumes hold great promise for improving a wide range of photonic devices and technologies, from lasers and LEDs to quantum communication and sensing, while also opening up possibilities in emerging fields such as quantum computing,” said the leading author Meng Xiong from the Technical University of Denmark. “For example, light sources based on these nanocavities could significantly improve communication by enabling faster data transmission and strongly reduced energy consumption.

Researchers have discovered an innovative approach to combat infectious viruses by leveraging a nanostructured surface. Their findings reveal that this surface successfully eradicated 96% of the viruses upon contact.

A new method using a nanostructured surface effectively kills 96% of viruses within six hours of contact.

There are approximately 425 million people worldwide with diabetes. Approximately 75 million of these inject themselves with insulin daily. Now, they may soon have a new alternative to syringes or insulin pumps. Scientists have found a new way to supply the body with smart insulin.

The new insulin can be eaten by taking a capsule or, even better, within a piece of chocolate.

Inside these are tiny nano-carriers in which the insulin is encapsulated. The particles are 1/10,000th the width of a human hair and so small that you cannot even see them under a normal microscope.

In the presence of protospacer adjacent motif (PAM), sgRNA accurately leads the Cas9 endonuclease to the target regions, where it causes DNA double strand breaks (DSBs), resulting in site‐specific genomic change. Endogenous DNA repair can take place following the creation of a DSB via two primary genome editing pathways: nonhomologous end joining (NHEJ) or homology‐directed repair (HDR).

By using the biological characteristics of Cas9 targeting specific DNA sequences under the guidance of sgRNA, scientists have further developed gene targeting activation and gene targeting inhibition tools based on dCas9, called CRISPRa and CRISPRi respectively.

In the paper, characteristics of three forms of CRISPR/Cas9 cargos are outlined. Three delivery forms of the CRISPR/Cas9 system are plasmids, mRNA/sgRNA, and ribonucleoprotein (RNP) complexes, each of which has its own advantages and disadvantages.

Nanotechnology offers specific benefits that will enable the future of cancer care. Find out here what these are.

A team of Rice University researchers mapped out how flecks of 2D materials move in liquid ⎯ knowledge that could help scientists assemble macroscopic-scale materials with the same useful properties as their 2D counterparts.

“Two-dimensional nanomaterials are extremely thin—only several atoms thick—sheet-shaped materials,” said Utana Umezaki, a Rice graduate student who is a lead author on a study published in ACS Nano. “They behave very differently from materials we’re used to in daily life and can have really useful properties: They can withstand a lot of force, resist high temperatures and so on. To take advantage of these unique properties, we have to find ways to turn them into larger-scale materials like films and fibers.”

In order to maintain their special properties in bulk form, sheets of 2D materials have to be properly aligned ⎯ a process that often occurs in solution phase. Rice researchers focused on graphene, which is made up of carbon atoms, and hexagonal boron nitride, a material with a similar structure to graphene but composed of boron and nitrogen atoms.

ICSPI, a leader in benchtop nanoscale imaging instruments, has announced the launch of its new Redux AFM, an automated atomic force microscope (AFM) designed to allow scientists and engineers to effortlessly collect 3-dimensional data at the nanoscale.

ICSPI’s mission is to expand access to nanoscale measurement with powerful, automated and intuitive imaging tools. Building on the success of its nGauge AFM, of which hundreds of units are in operation in over 30 countries, ICSPI is excited to introduce the Redux AFM and elevate the user experience of nanoscale imaging with automation.

Continue reading “Automated Atomic Force Microscope To Make 3D Nanoscale Data More Accessible” »

Plasmonics are special optical phenomena that are understood as interactions between light and matter and possess diverse shapes, material compositions, and symmetry-related behavior. The design of such plasmonic structures at the nanoscale level can pave the way for optical materials that respond to the orientation of light (polarization), which is not easily achievable in bulk size and existing materials.

In this regard, “shadow growth” is a technique that utilizes vacuum deposition to produce nanoparticles from a wide range of 2D and 3D shapes at nanoscale. Recent research progress in controlling this shadow effect has broadened the possibilities for the creation of different nanostructures.

Now, in twin studies led by Assistant Professor Hyeon-Ho Jeong from the Gwangju Institute of Science and Technology (GIST), Republic of Korea, researchers have comprehensively shed light on the recent advances in shadow growth techniques for hybrid plasmonic nanomaterials, including clock-inspired designs containing magnesium (Mg).

Steve P. Miller, PhD, has spent much of his career figuring out how to shut off autoimmune responses when he observed dying cells acting as carriers of autoantigens that could modulate the immune system. More than 20 years ago, while a professor at Northwestern University’s Feinberg School of Medicine, Miller discovered that dendritic cells (DCs), a subtype of antigen-presenting cells (APCs), could be changed or turned off to send the right signals to make immunologically tolerant T cells, also known as “tolerogenic.”

Miller’s attention turned toward investigating how best to mimic the apoptotic cells, overriding the expression of dendritic cells. So, Miller partnered with polymer chemist Lonnie D. Shea, PhD, who was at the McCormick School of Engineering, to develop a nanoparticle that interacts effectively with dendritic cells.

In 2013, Miller and Shea helped launch a company spun out of Northwestern University, when Shea was still in Chicago, called Cour Pharmaceutical Development Company, to develop innovative nanobiological therapeutics for acute inflammation, autoimmune, and allergic conditions. After years of experimentation, they developed a formula for nanoparticles of the right size and charge that interact well with the immune system, which is the foundation for their proprietary antigen-specific immune tolerance platform.