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COVID-19 mRNA vaccines and existing gene therapies, including those built with the CRISPR-Cas9 gene-editing tool, are delivered into cells with viral vectors or lipid nanoparticles. A research team led by CRISPR pioneer Feng Zhang, Ph.D., of the Broad Institute has developed a new mRNA delivery system that harnesses a human protein.

The system, dubbed SEND, leverages the ability of a human protein called PEG10 to bind to its own mRNA and form a protective capsule around it. In a new study published in Science, Zhang and colleagues engineered PEG10 to take on RNA cargoes of their choice and successfully delivered the system to mouse and human cells.

The findings support SEND as an efficient delivery platform for RNA-based gene therapies that can be repeatedly dosed, the researchers suggested. Because SEND uses a protein that’s produced naturally in the body, it may not trigger immune responses that can render gene therapies ineffective, the team said.

Artificial camouflage is the functional mimicry of the natural camouflage that can be observed in a wide range of species1,2,3. Especially, since the 1800s, there were a lot of interesting studies on camouflage technology for military purposes which increases survivability and identification of an anonymous object as belonging to a specific military force4,5. Along with previous studies on camouflage technology and natural camouflage, artificial camouflage is becoming an important subject for recently evolving technologies such as advanced soft robotics1,6,7,8 electronic skin in particular9,10,11,12. Background matching and disruptive coloration are generally claimed to be the underlying principles of camouflage covering many detailed subprinciples13, and these necessitate not only simple coloration but also a selective expression of various disruptive patterns according to the background. While the active camouflage found in nature mostly relies on the mechanical action of the muscle cells14,15,16, artificial camouflage is free from matching the actual anatomies of the color-changing animals and therefore incorporates much more diverse strategies17,18,19,20,21,22, but the dominant technology for the practical artificial camouflage at visible regime (400–700 nm wavelength), especially RGB domain, is not fully established so far. Since the most familiar and direct camouflage strategy is to exhibit a similar color to the background23,24,25, a prerequisite of an artificial camouflage at a unit device level is to convey a wide range of the visible spectrum that can be controlled and changed as occasion demands26,27,28. At the same time, the corresponding unit should be flexible and mechanically robust, especially for wearable purposes, to easily cover the target body as attachable patches without interrupting the internal structures, while being compatible with the ambient conditions and the associated movements of the wearer29,30.

System integration of the unit device into a complete artificial camouflage device, on the other hand, brings several additional issues to consider apart from the preceding requirements. Firstly, the complexity of the unit device is anticipated to be increased as the sensor and the control circuit, which are required for the autonomous retrieval and implementation of the adjacent color, are integrated into a multiplexed configuration. Simultaneously, for nontrivial body size, the concealment will be no longer effective with a single unit unless the background consists of a monotone. As a simple solution to this problem, unit devices are often laterally pixelated12,18 to achieve spatial variation in the coloration. Since its resolution is determined by the numbers of the pixelated units and their sizes, the conception of a high-resolution artificial camouflage device that incorporates densely packed arrays of individually addressable multiplexed units leads to an explosive increase in the system complexity. While on the other hand, solely from the perspective of camouflage performance, the delivery of high spatial frequency information is important for more natural concealment by articulating the texture and the patterns of the surface to mimic the microhabitats of the living environments31,32. As a result, the development of autonomous and adaptive artificial camouflage at a complete device level with natural camouflage characteristics becomes an exceptionally challenging task.

Our strategy is to combine thermochromic liquid crystal (TLC) ink with the vertically stacked multilayer silver (Ag) nanowire (NW) heaters to tackle the obstacles raised from the earlier concept and develop more practical, scalable, and high-performance artificial camouflage at a complete device level. The tunable coloration of TLC, whose reflective spectrum can be controlled over a wide range of the visible spectrum within the narrow range of temperature33,34, has been acknowledged as a potential candidate for artificial camouflage applications before21,34, but its usage has been more focused on temperature measurement35,36,37,38 owing to its high sensitivity to the temperature change. The susceptible response towards temperature is indeed an unfavorable feature for the thermal stability against changes in the external environment, but also enables compact input range and low power consumption during the operation once the temperature is accurately controlled.

Majoranas particles found.


Majorana particles have been getting bad publicity: a claimed discovery in ultracold nanowires had to be retracted. Now Leiden physicists open up a new door to detecting Majoranas in a different experimental system, the Fu-Kane heterostructure, they announce in Physical Review Letters.

Majorana particles are quasiparticles: collective movements of particles (electrons in this case) which behave as single particles. If detected in real life, they could be used to build stable quantum computers.

“Majoranas are quantum mechanical superpositions,” explains Gal Lemut. This superposition, a special kind of combination, comprises an electron and a hole (a place in a crystal where an electron is missing.

Deployment of functional circuits on a 3D freeform surface is of significant interest to wearable devices on curvilinear skin/tissue surfaces or smart Internet-of-Things with sensors on 3D objects. Here we present a new fabrication strategy that can directly print functional circuits either transient or long-lasting onto freeform surfaces by intense pulsed light-induced mass transfer of zinc nanoparticles (Zn NPs). The intense pulsed light can locally raise the temperature of Zn NPs to cause evaporation. Lamination of a kirigami-patterned soft semi-transparent polymer film with Zn NPs conforming to a 3D surface results in condensation of Zn NPs to form conductive yet degradable Zn patterns onto a 3D freeform surface for constructing transient electronics. Immersing the Zn patterns into a copper sulfate or silver nitrate solution can further convert the transient device to a long-lasting device with copper or silver. Functional circuits with integrated sensors and a wireless communication component on 3D glass beakers and seashells with complex surface geometries demonstrate the viability of this manufacturing strategy.

At the University of Chicago, scientists have developed an absolutely innovative, promising treatment for COVID-19 in the form of nanoparticles with the ability to trap SARS-CoV-2 viruses inside the body and use the body’s own immune system to kill them.

The “nanotraps” lure the virus by imitating the target cells infected by the virus. When the virus gets trapped by the nanotraps, it is then sequestered from other cells and targeted for destruction by the immune system.

Theoretically, these nanotraps could be used on different variants of the virus, resulting in a promising new way to suppress the virus in the future. The therapy is still in the early stages of testing, but the researchers believe that it could be administered through a nasal spray as a treatment for COVID-19.

Bio-Digital Twins, Quantum Computing, And Precision Medicine — Mr. Kazuhiro Gomi, President and CEO, and Dr. Joe Alexander, MD, Ph.D., Director, Medical and Health Informatics (MEI) Lab, NTT Research.


Mr. Kazuhiro Gomi, is President and CEO of NTT Research (https://ntt-research.com/), a division of The Nippon Telegraph and Telephone Corporation, commonly known as NTT (https://www.global.ntt/), a Japanese telecommunications company headquartered in Tokyo, Japan. Mr. Gomi has been at NTT for more than 30 years and was involved in product management/product development activities at the beginning of his tenure. In September of 2009, Mr. Gomi was first named to the Global Telecoms Business Power100 — a list of the 100 most powerful and influential people in the telecoms industry. He was the CEO of NTT America Inc. from 2010 to 2019 and also served on the Board of Directors at NTT Communications from 2012 to 2019. Mr. Gomi received a Masters of Science in Industrial Engineering from the University of Illinois at Urbana-Champaign, and a Master of Science in Electrical Engineering from Keio University, Tokyo. Mr. Gomi is a member of the board at US Japan Council, a non-profit organization aimed at fostering a better relationship between the US and Japan.

Dr. Joe Alexander, is Director of the Medical and Health Informatics (MEI) Lab at NTT Research, where he oversees the MEI Lab research in multi-scale Precision Cardiology platforms such as the cardiovascular bio-digital twin, as well as heart-on-a-chip technology, specifically aimed at developing the infrastructure for a digital replica of an individual’s heart. In addition, the MEI Lab is working on nano-and micro-scale sensors and electrodes, other organ-on-a-chip micro-fluidics technologies, as well as wearable and remote sensing to support future bio-digital twin applications.

Prior to 1970, bulletproof vests were pretty iffy, with a history extending as far as the 1500s when there were attempts to make metal armor that was bulletproof. By the 20th century there was ballistic nylon, but it took kevlar to produce garments with real protection against projectile impact. Now a 3D printed nanomaterial might replace kevlar.

A group of scientists have published a paper that interconnected tetrakaidecahedrons made up of carbon struts that are arranged via two-photon lithography.

We know that tetrakaidecahedrons sound like a modern invention, but, in fact, they were proposed by Lord Kelvin in the 19th century as a shape that would allow things to be packed together with minimum surface area. Sometimes known as a Kelvin cell, the shape is used to model foam, among other things.