Lifeboat Foundation

Researchers at Georgetown Lombardi Comprehensive Cancer Center have decoded a chain of molecules that are critical for the growth and survival of pancreatic ductal adenocarcinoma (PDAC)—the most common and also the most lethal form of pancreatic cancer.

They say their findings, published in Developmental Cell, suggest that inhibiting this “Yap” biological network may effectively regress early stage PDAC and could be paired with other drugs to halt more advanced stage tumors. Yap inhibitors have been developed and are moving into clinical trials.

Their study builds upon Georgetown Lombardi research that previously identified Yap as an oncogene central to the initiation of PDAC as well as a variety of other cancers. In the current study employing advanced animal models, they have managed to switch off Yap in pre-established PDAC tumors, and discovered that suppressing Yap blocks the metabolic pathways that provide the fuel and building materials for maintaining the growth of the cancer.

TEPIC, Mexico (Thomson Reuters Foundation) — Tequila, avocado and corn are proving their worth beyond Mexican fiesta staples as key components for a fast-growing bioplastics market, with companies transforming waste from processing food crops into products such as bags, plates and even car parts.

Bioplastics make up less than 5 percent of the millions of tonnes of plastic produced each year around the world.

But as governments and consumers fret about the damage plastic is doing to the world’s oceans, scientists are experimenting by converting materials from cactus to shrimp shells and human waste into alternative greener plastics.

This Mexican researcher has discovered a way to turn cactus leaves into a material with similar properties to plastic.

Supersolids, solid materials with superfluid properties (i.e., in which a substance can flow with zero viscosity), have recently become the focus of numerous physics studies. Supersolids are paradoxical phases of matter in which two distinct and somewhat antithetical orders coexist, resulting in a material being both crystal and superfluid.

First predicted at the end of the 1960s, supersolidity has gradually become the focus of a growing number of research studies, sparking debate across different scientific fields. Several years ago, for instance, a team of researchers published controversial results that identified this phase in solid helium, which were later disclaimed by the authors themselves.

A key issue with this study was that it did not account for the complexity of helium and the unreliable observations that it can sometimes produce. In addition, in atoms, interactions are typically very strong and steady, which makes it harder for this phase to occur.

Understanding the workings of our minds is one of science’s greatest challenges. With the help of flashing lights and materials used in diapers, we could find out what thoughts are made of.

Two separate teams of scientists have devised novel hydrodynamic “invisibility cloaks”—instead of shielding objects from light, the cloaks would shield them from fluid flows. The scientists described their work in two new papers in Physical Review Letters. These kinds of cloaking structures could one day help reduce drag on ships or submarines, or protect ships at a port or wharf from potential damage from strong waves.

Most so-called “invisibility cloaks” created thus far work in the electromagnetic regime and rely on metamaterials. A “metamaterial” is any material whose microscopic structure can bend light in ways light doesn’t normally bend—a property called “the index of refraction.” Natural materials have a positive index of refraction; certain manmade metamaterials—first synthesized in the lab in 2000—have a negative index of refraction, meaning they interact with light in such a way as to bend light around even very sharp angles.

At human scale, controlling temperature is a straightforward concept. Turtles sun themselves to keep warm. To cool a pie fresh from the oven, place it on a room-temperature countertop.

At the nanoscale—at distances less than 1/100th the width of the thinnest human hair—controlling temperature is much more difficult. Nanoscale distances are so small that objects easily become thermally coupled: If one object heats up to a certain temperature, so does its neighbor.

When scientists use a beam of light as that heat source, there is an additional challenge: Thanks to heat diffusion, materials in the beam path heat up to approximately the same temperature, making it difficult to manipulate the thermal profiles of objects within the beam. Scientists have never been able to use light alone to actively shape and control thermal landscapes at the nanoscale.

This robot sees and analyzes trash the same way a person does, but sorts it a lot faster 🤖.

It’s a problem that plagues even the priciest of lenses, manufactured to the most exacting specifications: the center of the frame might be razor-sharp, but the corners and edges always look a little soft. It’s a problem that’s existed for thousands of years with optical devices, and one that was assumed to be unsolvable until a Mexican physicist developed a mind-melting formula that could revolutionize how lenses are manufactured.

On paper, a curved glass lens should be able to redirect all the rays of light passing through it onto a single target known as its focal point. But in the real world, it just doesn’t work that way. Differences in refraction across the lens, as well as imperfections in its shape and materials, all contribute to some of those light rays, especially those entering the lens near its outer edges, missing the target. It’s a phenomenon known as spherical aberration, and it’s a problem that even Isaac Newton and Greek mathematician Diocles couldn’t crack.