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Dr. John S Torday — Lundquist Institute / UCLA — Aging And Disease As A Process Of Reverse Evolution

Dr. John Torday, Ph.D. is an Investigator at The Lundquist Institute of Biomedical Innovation, a Professor of Pediatrics and Obstetrics/Gynecology, and Faculty, Evolutionary Medicine, at the David Geffen School of Medicine at UCLA, and Director of the Perinatal Research Training Program, the Guenther Laboratory for Cell-Molecular Biology, and Faculty in the Division of Neonatology, at Harbor-UCLA Medical Center.

Dr. Torday studies the cellular-molecular development of the lung and other visceral organs, and using the well-established principles of cell-cell communication as the basis for determining the patterns of physiologic development, his laboratory was the first to determine the complete repertoire of lung alveolar morphogenesis. This highly regulated structure offered the opportunity to trace the evolution of the lung from its unicellular origins forward, developmentally and phylogenetically. The lung is an algorithm for understanding the evolution of other physiologic properties, such as in the kidney, skin, liver, gut, and central nervous system. Such basic knowledge of the how and why of physiologic evolution is useful in the effective diagnosis and treatment of disease.

Dr. Torday received his undergraduate degree in Biology and English from Boston University, and his MSc and PhD in Experimental Medicine from McGill University, Montreal, Canada. He did a post-doctoral Fellowship in Reproductive Endocrinology at the University of Wisconsin-Madison, WI.

Dr. Torday’s research has led to the publication of more than 150 peer-reviewed articles and 350 abstracts. More recently, he has gained an interest in the evolutionary aspects of comparative physiology and development, leading to the publication of 12 peer-reviewed articles on the cellular origins of vertebrate physiology, culminating in the book Evolutionary Biology, Cell-Cell Communication and Complex Disease.

Dr. Torday is also the co-author / co-editor on several volumes including: Evolution, the Logic of Biology, Evidence-Based Evolutionary Medicine, Morphogenesis, Environmental Stress and Reverse Evolution, and most recently, The Singularity of Nature: A Convergence of Biology, Chemistry and Physics.

Toward the development of drugs for aging-related diseases

In the search for ways to effectively combat age-related human disease, the enzyme sirtuin 6 (Sirt6) has recently become a focus of biochemical research. A targeted activation of Sirt6 could prevent or mitigate such diseases, for example some types of cancer. In a paper for the journal Nature Chemical Biology, biochemists from the University of Bayreuth have now shown how the small molecule MDL-801 binds to the enzyme Sirt6 and influences its activity. These findings stand to aid the development of new drugs.

Tissue Rejuvenation via Plasma Dilution | Irina Conboy, UC Berkeley

This is a detailed summary of plasma dilution and at 58:38 the future is explained where they will publish human results from 25 people, then start a company whose first order of business will be phase 3 trials with more people and placebo and hopefully funding. It appears you can pay to have the procedure. The hopeful start is this year in may.


Irina will present her recent findings on plasma dilution, showing that age-reversing effects, such as rejuvenating tissues in mice, can be achieved by.
diluting the blood plasma of old mice: Rejuvenation of three germ layers tissues by exchanging old blood plasma with saline-albumin.

Irina’s research focus.
A key direction of my laboratory is to understand age-imposed and pathological changes in molecular compositions of systemic and local environments of adult stem cells and to calibrate these to health — youth. In the past few years this direction has been ramified into synthetic biology, CRISPR technologies, bio-orthogonal proteomics and development of innovative digital bio-sensors that we collaboratively applied to the fields of aging and diagnostics of genetic diseases. Success in this research will improve our understanding of the determinants of homeostatic health and will enable novel rational approaches to treat a number of degenerative, fibrotic, metabolic and inflammatory diseases, as a class.

Zoom Transcription:
https://otter.ai/u/yhmNLEM7V52oOfW93lUfDWqL_uw

Dr. Matt Kaeberlein: Targeting Biological Ageing — A New Paradigm for 21st Century Medicine

Join us for Dr. Matt Kaeberlein’s presentation. He is the Founding Director of the UW Healthy Aging and Longevity Research Institute, and founder and co-Director of the Dog Aging Project and a Professor of Laboratory Medicine and Pathology at the University of Washington (UW) School of Medicine, with Adjunct appointments in Genome Sciences and Oral Health Sciences. Dr. Kaeberlein’s research interests are focused on biological mechanisms of aging in order to facilitate translational interventions that promote healthspan and improve quality of life.

“Our task is to make nature, the blind force of nature, into an instrument of universal resuscitation and to become a union of immortal beings.“
- Nikolai F. Fedorov.

We hold faith in the technologies & discoveries of humanity to END AGING and Defeat involuntary Death within our lifetime.

Working to Save Lives with Age Reversal Education.

========== Perpetual Life Creed ==========

We believe that all of life is sacred and that we have been given this one life to make unlimited. We believe in our Creator’s divine plan for all of humanity to have infinite lifespans in perfect health and eternal joy, rendering death to be optional.

Suppressor genes linked to less cancer and longer lifespan found in whales

A trio of researchers with ICAEV, Universidad Austral de Chile, and the University of Liverpool, respectively, have found suppressor genes linked to longevity and less cancer in two species of whales. In their paper published in the journal Proceedings of the Royal Society B, Daniela Tejada-Martinez, João Pedro de Magalhães and Juan C. Opazo, describe their genetic study of longevity in cetaceans and what they learned.

Interview with Harold Katcher

https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.…e=youtu.be

Hi everybody. Around 10 days ago, I participated in an online conference about aging, organized by HEALES and ILA, and Harold Katcher was one of the speakers. As each speaker had only 15 minutes for their presentation (and Harold spoke only for 10 minutes because he had some technical issues with Zoom), I thought that it would be a good idea to make an interview with him so that he has more time to speak about his rejuvenation therapy with E-5, the test with dogs, the timeframe for the arrival of the therapy for humans, and, above all else, his theory of aging. So, it’s a more informal conversation, but I think it helps everybody to know more about Harold Katcher, maybe one of the most (if not the most) influent people in human history.


Harold Katcher, one of the discoverers of the human breast cancer gene and possibly the discoverer of the greatest rejuvenation therapy to date, talks to Nicolas Chernavsky about his rejuvenation therapy with E-5, his carreer and his theory of aging. 2020 paper on experiments with E-5: https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.…1.full.pdf Harold’s 2013 paper on aging: https://link.springer.com/article/10.1134/S0006297913090137 Conboy’s 2005 paper on parabiosis: https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.…ature03260 1994 paper on human breast cancer gene: https://courses.washington.edu/gs466/readings/miki.pdf Find out more about Nicolas Chernavsky and NTZ on www.ntzplural.com #rejuvenation #aging #biotechnology #health #science.

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