All things must die, according to the poet Alfred Lord Tennyson, but that could be about to change.
A growing number of tech billionaires have decided they want to use their enormous wealth to try to help humans “cheat death.”
Amazon’s Jeff Bezos, Alphabet’s Larry Page, Oracle’s Larry Ellison and Palantir’s Peter Thiel are just a few of the super-rich who have taken a keen interest in the fast-emerging field of longevity, according to interviews, books and media reports.
A deepening understanding of the brain has created unprecedented opportunities to alleviate the challenges posed by disability. Scientists and engineers are taking design cues from biology itself to create revolutionary technologies that restore the function of bodies affected by injury, aging, or disease — from prosthetic limbs that effortlessly navigate tricky terrain to digital nervous systems that move the body after a spinal cord injury.
With the establishment of the new K. Lisa Yang Center for Bionics, MIT is pushing forward the development and deployment of enabling technologies that communicate directly with the nervous system to mitigate a broad range of disabilities. The center’s scientists, clinicians, and engineers will work together to create, test, and disseminate bionic technologies that integrate with both the body and mind.
Is an academic doctor and medical technology entrepreneur, working in the field of the computational biology of aging.
Dr. Radenkovic is also a Partner at the SALT Bio-Fund, and a co-founder of Hooke, an elite longevity research clinic in London.
Dr. Radenkovic has a dual degree in medicine and physiology from University College London Medical School, and did her residency at St Thomas’ Hospital in London. She later worked as Research Fellow at King’s College London and at Harvard University.
Dr. Radenkovic has led a variety of projects, including a digital therapeutics company for women and an algorithm for cardiac MRI based on fractal geometry, to major industry acquisitions.
Dr. Radenkovic has over 30 academic papers, 7 grants, and over 40 scientific conference presentations. She is fluent in 5 languages and 3 programming languages.
Red blood cells are the most abundant cell type in blood, carrying oxygen throughout the human body. In blood circulation, they repetitively encounter various levels of oxygen tension. Hypoxia, a low oxygen tension condition, is a very common micro-environmental factor in physiological processes of blood circulation and various pathological processes such as cancer, chronic inflammation, heart attacks and stroke. In addition, an interplay between poor cellular deformability and impaired oxygen delivery is found in various pathological processes such as sickle cell disease. Sickle red blood cells simultaneously undergo drastic mechanical deformation during the sickling and unsickling process.
The interactions between hypoxia and cell biomechanics and the underlying biochemical mechanisms of the accelerated damage in diseased red blood cells are well understood, however, the exact biomechanical consequences of hypoxia contributing to red blood cell degradation (aging) remains elusive.
Researchers from Florida Atlantic University’s College of Engineering and Computer Science, in collaboration with the Massachusetts Institute of Technology (MIT), sought to identify the role of hypoxia on red blood cell aging via the biomechanical pathways. In particular, they examined hypoxia-induced impairment of red blood cell deformability at the single cell level, compared the differences between non-cyclic hypoxia and cyclic hypoxia, and documented any cumulative effect vs. hypoxia cycles, such as aspects that have not been studied quantitatively. Red blood cell deformability is an important biomarker of its functionality.
Yes he starts with his personal controversy, emerging challenges, TAME, longevity is moving along well but has a long way to go.
Dr. Aubrey de Grey discusses the changing priorities at the forefront of the field of longevity rejuvenation research at Lifespan.io’s 2021 EARD conference. “The crusade is accelerating”, says Dr. De Grey, “but there’s so much still to do.”
De Grey is the author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is an international adjunct professor of the Moscow Institute of Physics and Technology, a fellow of the Gerontological Society of America, the American Aging Association, and the Institute for Ethics and Emerging Technologies.
SENS Research Foundation works to develop, promote, and ensure widespread access to therapies that cure and prevent the diseases and disabilities of aging by comprehensively repairing the damage that builds up in our bodies over time.
The annual Ending Age-Related Diseases (EARD) conference by Lifespan.io brings together longevity thought leaders together to exchange research reports, inspire and get inspired with new ideas, find collaborators, supporters, and mentors.
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This is the video of Harold Katcher’s presentation to the London Futurists. It was a great discussion, be sure to check it out.
#haroldkatcher #antiaging #rejuvenation #futurism
It has been known for some time that young blood plasma can confer beneficial effects on various organs in mice, although the mechanisms and implications remained unclear. A recent breakthrough experiment is attracting more attention to this area of research: rats treated with a blood plasma mixture known as E5 subsequently had their effective biological age measured by epigenetic clocks, involving 593 tissue samples. The result was a halving of the epigenetic ages of blood, heart, and liver tissue, and a lesser reduction (still statistically significant) in the epigenetic age of the hypothalamus. This has been heralded as the single most dramatic age-reversal experiment in mammals to date.
On Saturday 18th September, the lead designer of these experiments, Dr Harold Katcher, joined London Futurists to present his analysis of the findings, his own distinctive theories of aging, and his expectation for future research and applications. He also answered questions about his new book, “The Illusion of Knowledge: The paradigm shift in aging research that shows the way to human rejuvenation”, which is available at https://www.amazon.co.uk/Illusion-Knowledge-paradigm-researc…09C7JNB64/
The event was introduced and moderated by David Wood, Chair of London Futurists.
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Levine’s Biological age calculator is embedded as an Excel file in this link:
A newly discovered manipulation mechanism used by parasitic bacteria to slow down plant aging, may offer new ways to protect disease-threatened food crops.
Parasites manipulate the organisms they live off to suit their needs, sometimes in drastic ways. When under the spell of a parasite, some plants undergo such extensive changes that they are described as “zombies”. They stop reproducing and serve only as a habitat and host for the parasitic pathogens.
Until now, there’s been little understanding of how this happens on a molecular and mechanistic level.
What do you do when you’re so rich you could live to be a hundred and still not spend a noticeable fraction of your fortune? Buy yourself some more time. Literally.
The Amazon founder Jeff Bezos, 57 was reported last week to be among the backers of a new “rejuvenation company”, Altos Labs, a Silicon Valley start-up that has set its sights on understanding why we age and how we might prevent it — and ultimately work out how we might live for ever.
Bezos is not the only billionaire looking towards his end days. The men behind Google and Facebook are also dabbling in the dark art of manipulating mortality. But are they altruistically investing for the good of humanity — or is this.
Hey it’s Han from WrySci HX talking about a really interesting concept — the world’s first biological gaming console that uses nanopore technology to detect molecules, and turn these readouts into games! It’s called the Demonpore 64! More below ↓↓↓
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