You heard about reversing the epigenetic clock 2.5 years? Living drugs? CAR T cells? Fight cancer? Here ya go.
Vision Weekend is the annual member gathering of Foresight Institute, a non-profit for advancing beneficial technologies for the long-term flourishing of life.
Intermittent fasting means interspersing periods of abstaining from food with periods of eating regularly. You could skip breakfast and eat a late lunch, for example, or fast all day long, once or twice a week.
The research suggests that intermittent fasting is a simple, effective life hack for solving many age-related problems, but the evidence is far from conclusive.
“There really is no one weird trick for the perfect diet for everyone,” John Newman, geriatrician at the University of California, San Francisco told Inverse. Science is leading us toward the idea of maintaining some flexibility in our body’s metabolism, he said.
Transhumanism can mean uploading one’s mind into cyberspace. But some transhumanists hope to slowly morph into “immortal cyborgs” with endlessly replaceable parts.
Five years ago, we were told, we were all turning into cyborgs:
Did you recently welcome a child into the world? Congratulations! An upstanding responsible parent such as yourself is surely doing all you can to prepare your little one for all the pitfalls life has in store. However, thanks to technology, children born in 2014 may face a far different set of issues than you ever had to. And we’re not talking about simply learning to master a new generation of digital doohickeys, we’re talking about living in a world in which the very definition of “human” becomes blurred.
From insilico meddicine — the beginning of an AI healthcare revolution.
Poly Mamoshina on Machine Learning for small molecule drug discovery and the beginning of an AI healthcare revolution — interviewed at the Undoing Aging conference in Berlin 2019!
Continue reading “Polina Mamoshina — The Beginning of an AI Healthcare Revolution” »
Whenever I see my 10-year-old daughter brimming over with so much energy that she jumps up in the middle of supper to run around the table, I think to myself, “those young mitochondria.” Mitochondria are our cells’ energy dynamos.
A new study shows that short-term treatment with the common organ rejection drug rapamycin reverses periodontal bone loss, attenuates inflammation, and makes the oral microbiome revert to a more youthful state in old mice.
What is rapamycin?
Rapamycin (also known as sirolimus) is a macrolide, a class of antibiotics that includes Biaxin (Clarithromycin), Zithromax (Azithromycin), Dificid (Fidoximycin), and Erythromycin. Macrolides inhibit the growth of bacteria and are often used in the treatment of common bacterial infections.
A global movement.
Click here to open page.
Aubrey de Grey will be the opening speaker at our launch meeting. He will discuss the need for an organized Health and Life Extension movement and related topics. Q and A to follow.
Continue reading “Aubrey de Grey Speaks on Organizing the Movement” »
From the beginning of time, humankind has searched for the secret to a long life. Now science may have found an answer, in the form of molecular augury. The pattern of chemical chains that attach to the DNA in your cells—on-off switches known as epigenetic markers—can reveal how swiftly you are aging, and perhaps even how much longer you will live. While genetic testing might tell you where you came from, epigenetics promises a glimpse into the future. Now, a handful of companies are offering commercial blood or saliva tests based on the science of epigenetics—a chance to find out how old you truly are.
Companies claim they can now easily calculate your biological age. Should you take them up on it?
Objective Failing to properly repair damaged DNA drives the ageing process. Furthermore, age-related inflammation contributes to the manifestation of ageing. Recently, we demonstrated that the efficiency of repair of diethylnitrosamine (DEN)-induced double-strand breaks (DSBs) rapidly declines with age. We therefore hypothesised that with age, the decline in DNA damage repair stems from age-related inflammation.
Design We used DEN-induced DNA damage in mouse livers and compared the efficiency of their resolution in different ages and following various permutations aimed at manipulating the liver age-related inflammation.
Results We found that age-related deregulation of innate immunity was linked to altered gut microbiota. Consequently, antibiotic treatment, MyD88 ablation or germ-free mice had reduced cytokine expression and improved DSBs rejoining in 6-month-old mice. In contrast, feeding young mice with a high-fat diet enhanced inflammation and facilitated the decline in DSBs repair. This latter effect was reversed by antibiotic treatment. Kupffer cell replenishment or their inactivation with gadolinium chloride reduced proinflammatory cytokine expression and reversed the decline in DSBs repair. The addition of proinflammatory cytokines ablated DSBs rejoining mediated by macrophage-derived heparin-binding epidermal growth factor-like growth factor.
Rejuvenation Roundup November 2019
Quite a number of readily understandable reviews were published this month, along with an X10 episode on epigenetic alterations; if you’re new to the biology of aging or want to introduce someone else to the topic with new material, this is a great time to start.
LEAF News
