Lifeboat Foundation

The researchers found that while equol production did not appear to impact levels of amyloid-beta deposited within the brain, it was associated with reduced white matter lesion volumes. Sekikawa’s team also discovered that high levels of isoflavones—soy nutrients that are metabolized into equol—had no effect on levels of white matter lesions or amyloid-beta when equol wasn’t produced.

According to Sekikawa, the ability to produce equol from soy isoflavones may be the key to unlocking protective health benefits from a soy-rich diet, and his team has previously shown that equol production is associated with a lower risk of heart disease. As heart disease is strongly associated with cognitive decline and dementia, equol production could help protect the aging brain as well as the heart.

A metabolite produced following consumption of dietary soy may decrease a key risk factor for dementia—with the help of the right bacteria, according to a new discovery led by researchers at the University of Pittsburgh Graduate School of Public Health.

Continue reading “Bacterial metabolism of dietary soy may lower risk factor for dementia” »

Have you gotten your genome sequenced yet? How important do you think genetic testing is to planning your own personalized longevity regimen?

We cover the benefits of genetic testing for longevity, and why you should consider getting a DNA test if you want to extend your lifespan.

OneSkin Technologies is a longevity company started by a team of incredible female PHDs and entrepreneurs, who have been using cutting edge technology to identify the senescent cells that cause your skin to age.
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Discover how they use key peptide molecules to eliminate those senescent cells, making you look and feel 10 years younger.

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Our immune system’s capacity to mount a well-regulated defense against foreign substances, including toxins, weakens with age and makes vaccines less effective in people over age 65. At the same time, research has shown that immunotherapy targeting neurotoxic forms of the peptide amyloid beta (oligomeric Aβ) may halt the progression of Alzheimer’s disease, the most common age-related neurodegenerative disease.

A team led by Chuanhai Cao, Ph.D., of the University of South Florida Health (USF Health), has focused on overcoming, in those with impaired immunity, excess inflammation and other complications that interfere with development of a therapeutic Alzheimer’s vaccine.

Now, a preclinical study by Dr. Cao and colleagues indicates that an antigen-presenting dendritic vaccine with a specific antibody response to oligomeric Aβ may be safer and offer clinical benefit in treating Alzheimer’s disease. The vaccine, called E22W42 DC, uses immune cells known as dendritic cells (DC) loaded with a modified Aβ peptide as the antigen.

“Who are we? What are we composed of? What is matter? What does matter? Is the body just a vessel with an expiration date?” asks American rapper GZA from Wu-Tang Clan, in Liquid Science, the show about science and imagination he hosts on Red Bull TV. In this episode, GZA is on a “quest to understand the human desire to live forever”.

Trying to find answers to such questions is nothing new. In an opinion piece for the Washington Post titled ‘‘Transhumanist’ eternal life? No thanks, I’d rather learn not to fear death’, Arthur C Brooks explains that, back in the fifth century before Christ, Greek historian Herodotus wrote about “a race of people in northern Africa who, according to local lore, never seemed to age”.

Eternal youth and immortality have always fascinated humanity, but we’ve not had much success finding them. Until now.

First in a series of Longevity Dialogues. Suggestions for future focus encouraged.

Host Mark Sackler conducts a lively discussion on issues involved with the anticipated implementation and implications of radical life extension. With XPrize innovation board member Sergey Young, and futurist authors David Wood and Jose Cordeiro.

Here’s my latest post!

Sleep changes during aging may impact Alzheimer’s disease risk, and with the goal of minimizing that risk, can sleep, in particular, levels of deep sleep, be optimized?

However, it was unclear how TERRA got to the tip of chromosomes and remained there. “The telomere makes up only a tiny bit of the total chromosomal DNA, so the question is ‘how does this RNA find its home?’” Lingner says. To address this question, postdoc Marianna Feretzaki and others in the teams of Joachim Lingner at EPFL and Lumir Krejci at Masaryk University set out to analyze the mechanism through which TERRA accumulates at telomeres, as well as the proteins involved in this process. The findings are published in * Nature*.

**Finding home**

By visualizing TERRA molecules under a microscope, the researchers found that a short stretch of the RNA is crucial to bring it to telomeres. Further experiments showed that once TERRA reaches the tip of chromosomes, several proteins regulate its association with telomeres. Among these proteins, one called RAD51 plays a particularly important role, Lingner says.

Continue reading “Scientists home in on the mechanism that protects cells from premature aging” »