Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: life extension – Page 122

In a groundbreaking endeavor, researchers at the University of Rochester have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse’s lifespan.

Naked mole rats, known for their long lifespans and exceptional resistance to age-related diseases, have long captured the attention of the scientific community. By introducing a specific gene responsible for enhanced cellular repair and protection into mice, the Rochester researchers have opened exciting possibilities for unlocking the secrets of aging and extending human lifespan.

“Our study provides a proof of principle that unique longevity mechanisms that evolved in long-lived mammalian species can be exported to improve the lifespans of other mammals,” says Vera Gorbunova, the Doris Johns Cherry Professor of biology and medicine at Rochester. Gorbunova, along with Andrei Seluanov, a professor of biology, and their colleagues, report in a study published in Nature that they successfully transferred a gene responsible for making high molecular weight hyaluronic acid (HMW-HA) from a naked mole rat to mice. This led to improved health and an approximate 4.4 percent increase in median lifespan for the mice.

Read more | >

I recently just read a post about the “University of Queensland researchers discovered that the protein ATFS-1 aids in cell longevity by balancing new mitochondria creation and repair.”

It reminded me of this:

I recently came across an article about nurturing your mitochondria. One of the benefits to doing this relates to aging — apparently looking after your mitochondria will help counteract much of what we associate with aging, such as declining energy levels.

What I also found fascinating — their suggestions fit very well with many of the methods I’ve been using to fight cancer.

For example:

Read more | >

Peter Diamandis is best known as the founder of the XPrize Foundation, which offers big cash prizes as an incentive for tech solutions to big problems. The entrepreneur and investor is also co-founder of the Singularity University, a Silicon Valley-based nonprofit offering education in futurology. His new book, The Future Is Faster Than You Think, argues that the already rapid pace of technological innovation is about to get a whole lot quicker.

Do you think people are worried about where technology is going to take us? I can palpably feel how fast things are changing and that the rate of change is accelerating, and I have picked up a growing amount of fear coming from people who don’t understand where the world is going. And that is not good when you’re trying to solve problems. This book is about giving people a roadmap for where things are going over the next decade so they have less fear and more anticipation. Because, yes, in the next 10 years, we’re going to reinvent every industry on this planet, but the change is one that is for the benefit of masses, whether it’s in longevity or food or banking.

Read more | >

“Microglia exhibit both maladaptive and adaptive roles in the pathogenesis of neurodegenerative diseases and have emerged as a therapeutic target for central nervous system (CNS) disorders, including those affecting the retina,” wrote the researchers. “Replacing maladaptive microglia, such as those impacted by aging or over-activation, with exogenous microglia that enable adaptive functions has been proposed as a potential therapeutic strategy for neurodegenerative diseases. To investigate the potential of microglial cell replacement as a strategy for retinal diseases, we first employed an efficient protocol to generate a significant quantity of human-induced pluripotent stem cells (hiPSC)-derived microglia.”

“Our understanding of microglia function comes predominantly from rodent studies due to the difficulty of sourcing human tissue and isolating the microglia from these tissues. But there are genetic and functional differences between microglia in mice and humans, so these studies may not accurately represent many human conditions,” explained lead author Wenxin Ma, a PhD, biologist at the Retinal Neurophysiology Section, National Eye Institute, National Institutes of Health.

“To address this concern, researchers have been growing human microglia from human stem cells. We wanted to take this a step further and see if we could transplant human microglia into the mouse retina, to serve as a platform for screening therapeutic drugs as well as explore the potential of microglia transplantation as a therapy itself,” added senior author Wai Wong, vice president of retinal disease, Janssen Research and Development.

Read more | >

Step forward platelet factor 4 (PF4): this substance in the blood has been linked to the mental boost we get from exercise, the benefits of blood transfusions, and a protein associated with longevity, in three separate studies.

All three processes promote cognitive enhancement, meaning PF4 is something of a superpowered blood factor. The research was carried out by two teams from the University of California San Francisco (UCSF) in the US and the University of Queensland in Australia.

Platelets are cell fragments that play a critical role in the clotting process. Aside from serving as physical plugs that staunch bleeding, these small, non-nucleated chunks of bone marrow cell contain granules that release chemicals to promote aggregation.

Read more | >

Researchers at The University of Queensland have found an anti-aging function in a protein deep within human cells.

Associate Professor Steven Zuryn and Dr. Michael Dai at the Queensland Brain Institute have discovered that a protein called ATSF-1 controls a fine balance between the creation of new mitochondria and the repair of damaged mitochondria.

Read more | >

High-resolution 3D retina images have specific markers that can indicate the risk of Parkinson’s in a person. A new AI program can identify these markers and tell whether or not you have the disease.

Although Parkinson’s disease (PD) is incurable, a non-profit National Council of Aging report suggests that early detection and treatment could help patients live a long and productive life even with the disease.

However, in reality, even by the age of 50, less than 10 percent of patients are diagnosed. In fact, most PD patients found out about the condition in their 60s, and by then, it is too late for any treatment to work effectively.

Read more | >

A new research paper was published by Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) in Volume 15, Issue 15, entitled, “Associations between klotho and telomere biology in high stress caregivers.”

Aging biomarkers may be related to each other through direct co-regulation and/or through being regulated by common processes associated with chronological aging or stress. Klotho is an aging regulator that acts as a circulating hormone with critical involvement in regulating insulin signaling, phosphate homeostasis, oxidative stress, and age-related inflammatory functioning.

In this new study, researchers Ryan L. Brown, Elissa E. Epel, Jue Lin, Dena B. Dubal, and Aric A. Prather from the Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, Department of Biochemistry and Biophysics, University of California, San Francisco, and the Department of Neurology and Weill Institute of Neurosciences, University of California, San Francisco discuss the association between klotho levels and telomere length of specific sorted immune cells among a healthy sample of mothers caregiving for a child with autism spectrum disorder (ASD) or a child without ASD — covarying age and body mass index — in order to understand if high stress associated with caregiving for a child with an ASD may be involved in any association between these aging biomarkers.

Read more | >

O.o!!! The longevity of this complex organism could reveal new avenues for immortality.

Arenaerpeton supinatus was discovered in rocks cut from a nearby quarry that were intended for the building of a garden wall.

A 240-million-year-old fossil of an amphibian was found in a retaining wall in the 1990s. This significant find has now been formally named and described by scientists at the University of New South Wales (UNSW Sydney) and the Australian Museum.

The fossil was originally discovered by a retired chicken farmer in rocks from a local quarry. These rocks were intended for use in constructing a garden retaining wall, and the fossil was subsequently donated to the Australian Museum in Sydney.

Read more | >

We all know having a balanced diet is important to stay healthy. New research from Waseda University has started to unpick the optimum proportion of macronutrients for a diet that supports metabolic health as we age – starting with protein. The study is published in GeroScience.

Linking diet to “healthspan”

Over our lifespans, our nutrition needs change. By optimizing our diets according to what our bodies need (in relation to our age), we can maintain our metabolic health and thereby increase our “healthspan”, with healthspan referring to the length of time in our lives that we spend in good health.

Read more | >