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Category: life extension – Page 122

Regulatory mechanism that keeps the immune system in check identified

Researchers from the UoC’s Center for Biochemistry at the Faculty of Medicine and the UoC CECAD Cluster of Excellence in Aging Research have discovered that an excessive immune response can be prevented by the intramembrane protease RHBDL4.

In a study now published in Nature Communications under the title “RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling,” the previously unknown regulatory mechanism is described.

The researchers discovered that the cleavage of a cargo receptor by a so-called intramembrane reduces the localization of a central immune receptor on the and thereby the risk of an overreaction of the immune system.

Researchers demonstrate 3D nanoscale optical disk memory with petabit capacity

The most popular words of 2023 were recently released, with AI Large Language Model (LLM) unquestionably topping the list. As a front-runner, ChatGPT also emerged as one of the international buzzwords of the year. These disruptive innovations in AI owe much to big data, which has played a pivotal role. Yet, AI has simultaneously presented new opportunities and challenges to the development of big data.

High-capacity data storage is indispensable in today’s digital economy. However, major storage devices like and semiconductor flash devices face limitations in terms of cost-effectiveness, durability, and longevity.

Optical data storage offers a promising green solution for cost-effective and long-term data storage. Nonetheless, optical data storage encounters a fundamental limitation in the spacing of adjacent recorded features, owing to the optical diffraction limit. This physical constraint not only impedes the further development of direct laser writing machines but also affects and storage technology.

A Randomized, Controlled Clinical Trial Demonstrates Improved Cognitive Function in Senior Dogs Supplemented with a Senolytic and NAD+ Precursor Combination

Aging reversed in dogs face_with_colon_three

Age-related decline in mobility and cognition are associated with cellular senescence and NAD+ depletion in dogs and people. A combination of a novel NAD+ precursor and senolytic, LY-D6/2 was examined in this randomized controlled trial. Seventy dogs were enrolled and allocated into placebo, low or full dose groups. Primary outcomes were change in cognitive impairment measured with the owner-reported Canine Cognitive Dysfunction Rating (CCDR) scale and change in activity measured with physical activity monitors. Fifty-nine dogs completed evaluations at the three-month primary endpoint, and 51 reached the six-month secondary endpoint. There was a significant difference in CCDR score across treatment groups from baseline to the primary endpoint (p=0.02) with the largest decrease in the full dose group. There were no significant differences between groups in changes in measured activity. However, the proportion of dogs that improved in frailty and owner-reported activity levels and happiness was higher in the full dose group than other groups. Adverse events occurred equally across groups. All groups showed improvement in cognition, frailty, and activity suggesting placebo effect and benefits of trial participation. We conclude that LY-D6/2 significantly improves owner-assessed cognitive function and may have broader effects on frailty, activity and happiness as reported by owners.

The authors have declared no competing interest.

RSS2024 Program and Speakers

The Forever Healthy Foundation is pleased to announce the Rejuvenation Startup Summit 2024 program and full speaker list.

The Rejuvenation Startup Summit (Berlin, May 10–11, 2024) is a vibrant networking event that brings together startups and members of the longevity venture capital/investor ecosystem – all aiming to create therapies to vastly extend the healthy human lifespan. Rejuvenation and longevity biotech is a new, emerging field of medicine. It aims to prevent and reverse the diseases of aging by addressing their common root cause, the aging process itself.

In addition to an exciting range of presentations from CEOs of startups in the fields of rejuvenation & longevity, the summit features an all-day startup forum for networking, panel discussions, and keynote presentations. Starting midday on Friday and finishing off on Saturday night with a party for all attendees, the summit offers ample opportunity to connect with some of the most promising leaders in the field, including:

THIS Therapy Slows Down The Aging Clock By 31% — Successful Clinical Cases

Dr. Dian Ginsberg presents what causes aging and successful cases of patients who shows DunedInPace of aging reduction by using a therapy in this video.

For More About Dr. Dian Ginsberg.
Website – Studies \& Researches.
https://www.youngplasmastudy.com/
https://dianginsbergmd.com/

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Study unlocks nanoscale secrets for designing next-generation solar cells

Perovskites, a broad class of compounds with a particular kind of crystal structure, have long been seen as a promising alternative or supplement to today’s silicon or cadmium telluride solar panels. They could be far more lightweight and inexpensive, and could be coated onto virtually any substrate, including paper or flexible plastic that could be rolled up for easy transport.

In their efficiency at converting sunlight to electricity, perovskites are becoming comparable to silicon, whose manufacture still requires long, complex, and energy-intensive processes. One big remaining drawback is longevity: They tend to break down in a matter of months to years, while silicon can last more than two decades. And their efficiency over large module areas still lags behind silicon.

Now, a team of researchers at MIT and several other institutions has revealed ways to optimize efficiency and better control degradation, by engineering the nanoscale structure of perovskite devices.

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