Lifeboat Foundation: Safeguarding Humanity
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Category: life extension – Page 118

Starting at 12:40 Liz asks what would your perfect virtual world be like. Not sure what my home world would be like, a Maldives island, an orbital ring colony perhaps. I think my main form of entertainment would be to adventure in the worlds people will create, and perhaps help build them. Someone will detail the 30 million worlds of A Galaxy Far Far Away and go play in it, someone will create a Star Trek Galaxy, D&D, Niven’s Known Space, Potter-verse, LOTR, and so on.

Only a handful of people in the entire world are aware of the work that is going on to increase the lifespan of #humans. Not just in terms of numbers, but also in terms of the quality of life. Most people today are unable to imagine living beyond 80–90, and they absolutely cannot imagine living an active life at 80–90 or beyond, to say nothing of living forever, and leading an active life forever.

But, the reality is that living forever is going to be a reality in the near future. You can catch up on what’s going on in the #longevity space at The Buying Time Podcast.

Continue reading “Ep#09 Liz & Sar: Did you know you can live forever?” | >

In a groundbreaking study, researchers have unlocked a new frontier in the fight against aging and age-related diseases. The study, conducted by a team of scientists at Harvard Medical School, has published the first chemical approach to reprogram cells to a younger state. Previously, this was only achievable using a powerful gene therapy.

On July 12, 2023, researchers from Harvard Medical School, University of Maine and Massachusetts Institute of Technology (MIT) published a new research paper in Aging, titled, “Chemically induced reprogramming to reverse cellular aging.”

The team’s findings build upon the discovery that the expression of specific genes, called Yamanaka factors, could convert adult cells into induced (iPSCs). This Nobel Prize-winning discovery raised the question of whether it might be possible to reverse cellular aging without causing cells to become too young and turn cancerous.

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In a groundbreaking study, researchers have unlocked a new frontier in the fight against aging and age-related diseases. The study, conducted by a team of scientists at Harvard Medical School, has published the first chemical approach to reprogram cells to a younger state. Previously, this was only achievable using a powerful gene therapy.

Researchers from Harvard Medical School, University of Maine and Massachusetts Institute of Technology (MIT) published a new research paper in Aging, titled, “Chemically induced reprogramming to reverse cellular aging.”

Read more | >

For cellular agriculture—a technique that grows meat in bioreactors—to successfully feed millions, numerous technological hurdles must be conquered. The production of muscle cells from sources such as chicken, fish, cows, and more will need to increase to the point where millions of metric tons are yielded annually.

Researchers at the Tufts University Center for Cellular Agriculture (TUCCA) have made strides toward this objective by developing immortalized bovine muscle stem cells (iBSCs). These cells possess a rapid growth rate and the ability to divide hundreds of times, potentially even indefinitely, furthering the potential for large-scale meat production.

This advance, described in the journal ACS Synthetic Biology, means that researchers and companies around the globe can have access to and develop new products without having to source cells repeatedly from farm animal biopsies.

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A new study conducted by researchers at Washington University School of Medicine in St Louis has explored the composition of gut bacteria in individuals in the earliest stage of Alzheimer’s disease. The research, which is published in Science Translational Medicine, not only identifies potential indicators of heightened dementia risk, but also offers prospects for developing microbiome-altering preventive treatments to combat cognitive decline.

Longevity. Technology: Previously, science has noted differences in the gut microbiomes of individuals with symptomatic Alzheimer’s compared with their healthy counterparts. However, the current study delves deeper, focusing on the gut microbiomes of individuals in the crucial pre-symptomatic phase. During this phase, individuals accumulate amyloid beta and tau proteins in their brains without exhibiting neurodegeneration or cognitive decline, which can persist for over two decades. Earlier diagnosis would enable people to access support and resources, plan for the future and well as onboarding treatments that could slow the progression of the disease. An idea of future numbers of patients would also allow health care infrastructure to be better prepared.

The researchers evaluated participants who volunteered at the Charles F and Joanne Knight Alzheimer Disease Research Center at Washington University, specifically selecting cognitively normal individuals. These participants provided samples of stool, blood, and cerebrospinal fluid, recorded their dietary habits, and underwent PET and MRI brain scans.

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Back in 1956, Denham Harman proposed that the aging is caused by the build up of oxidative damage to cells, and that this damage is caused by free radicals which have been produced during aerobic respiration [1]. Free radicals are u nstable atoms that have an unpaired electron, meaning a free radical is constantly on the look-out for an atom that has an electron it can pinch to fill the space. This makes them highly reactive, and when they steal atoms from your body’s cells, it is very damaging.

Longevity. Technology: As well as being generated in normal cell metabolism, free radicals can be acquired from external sources (pollution, cigarette smoke, radiation, medication, &c) and while the free radical theory of aging has been the subject of much debate [2], the understanding of the danger free radicals pose led to an increase in the public’s interest in superfoods, vitamins and minerals that were antioxidants – substances that have a spare electron which they are happy to give away to passing free radicals, thus removing them from the danger equation.

But before you reach for the blueberries, it is important to know that, as so often in biology, the story is not black and white. Like a misunderstood cartoon villain, free radicals have a beneficial side, too – albeit in moderation. Free radicals generated by the cell’s mitochondria are beneficial in wound-healing, and others elsewhere act as important signal substances. Used as weapons by the body’s defense system, free radicals destroy invading pathogenic microbes to prevent disease.

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Autophagy plays important but complex roles in aging, affecting health and longevity. We found that, in the general population, the levels of ATG4B and ATG4D decreased during aging, yet they are upregulated in centenarians, suggesting that overexpression of ATG4 members could be positive for healthspan and lifespan. We therefore analyzed the effect of overexpressing Atg4b (a homolog of human ATG4D) in Drosophila, and found that, indeed, Atg4b overexpression increased resistance to oxidative stress, desiccation stress and fitness as measured by climbing ability. The overexpression induced since mid-life increased lifespan. Transcriptome analysis of Drosophila subjected to desiccation stress revealed that Atg4b overexpression increased stress response pathways. In addition, overexpression of ATG4B delayed cellular senescence, and improved cell proliferation.

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Have you ever wondered about the future of aging? What if I told you that we’re on the brink of a revolution that could redefine what it means to grow old … with gene therapy.

Today, I want to introduce you to a woman who is not just imagining this future, but actively creating it.

Meet Liz Parrish, the trailblazing CEO of BioViva, a biotech company that’s pushing the boundaries of what’s possible with gene therapies.

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Can you really die in the digital age? It’s a question that plagues performance artist Georgia Banks. Not only is this question a recurring theme in her work, but it’s also a concept she lives by.

Since earning a Master of Fine Arts (MFA) from the VCA in 2015, Georgia Banks has consistently skirted the boundaries between art and life through her performance-based works.

Through her practice, Banks has clinched a beauty pageant title, auctioned off the rights to her funeral, endured a crucifixion, and been sued by the estate of American artist Hannah Wilke.

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A team of scientists led by Nanyang Technological University, Singapore (NTU Singapore) has found that an existing cancer drug could be repurposed to target a subset of cancers that currently lack targeted treatment options and are often associated with poor outcomes.

This subset of cancers makes up 15% of all cancers and is especially prevalent in aggressive tumors such as osteosarcoma (bone tumor) and glioblastoma (brain tumor).

These cancerous cells stay “immortal” using a mechanism called the alternative lengthening of telomeres (ALT), but the team has demonstrated that ponatinib, a cancer approved by the US Food and Drug Administration, blocks key steps in the ALT mechanism that leads it to fail.

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