Transiently reprogramming human fibroblasts up to the maturation phase rejuvenates cells according to several aging markers whilst enabling them to return to their original identity.
Category: life extension – Page 103
Free Radicals Extend Lifespan?
In this edition, we’ll take a look at a Canadian study which shows that reducing a worm’s ability to fight free radicals in a specific organ could increase it’s lifespan. Does this have any implications for humans?
Contents:
Intro 0:00
Graphical Abstract 1:49
Figure 1. Tissue-specific re-expression of sod-2 rescues deficits in fertility and embryonic lethality in clk-1;sod-2 mutants 2:28
Figure 2. Tissue-specific re-expression of sod-2 can decrease stress resistance in clk-1;sod-2 worms 5:37
Figure 3. Tissue-specific re-expression of sod-2 is not sufficient to reduce clk-1;sod-2 lifespan 6:41
Figure 4. Disruption of mitochondrial superoxide dismutase in the intestine is sufficient to increase lifespan 7:33
Figure 5. Intestine-specific knockdown of sod-2 is sufficient to enhance resistance to heat stress 9:33
Figure 6. Intestine-specific knockdown of sod-2 does not affect physiologic rates 10:29
Conclusion & Next Steps 11:40
Study reviewed:
Intestine-specific disruption of mitochondrial superoxide dismutase extends longevity.
https://www.sciencedirect.com/science/article/pii/S0891584925000383
2009 paper from the same authors:
Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans.
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.
General overview of the pros and cons of free radicals for lifespan:
Reversing Senescence with Exosomes
Introducing a new weekly video series showcasing the latest impactful longevity related studies.
” +Study reviewed: Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice.
A new weekly series showcasing the latest and most impactful longevity studies.
In this first edition, we’ll take a look at how a subset of blood stem cells from old mice can be used to rejuvenate the blood & immune systems of other old mice and increase their lifespans.
Study reviewed:
Young Plasma Improves Surgery
Reviewing a trial where young blood plasma was used during joint replacement surgery in older adults, reducing immune system related inflammation and speeding up recovery. This is one of the first human trials of young plasma after many positive results in mice.
Contents:
Intro 0:00
Study Overview 1:07
Proteomic Changes 1:45
Immune Response 3:07
Specific Immune Cell Changes 4:22
Patient Outcomes 6:09
Conclusion 7:44
Study reviewed:
Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial.
https://translational-medicine.biomedcentral.com/articles/10…45;06215-w.
If you liked this video, please consider supporting its creation via a donation to the Canadian Longevity Association, which will not only help create these videos, but also help our other advocacy and outreach efforts:
https://www.zeffy.com/en-CA/donation-form/c47dd699-b5bd-4d28…26f77ddcf3
Or, order something from our new merchandise shop:
January 2025 Longevity Review
Kicking off the first Longevity Review of 2025 with a look at how exosomes can reverse cellular senescence and lengthen lifespan; how there is a subset of youthful stem cells in older animals which can increase lifespan; the most comprehensive study of life extending molescules in the roundworm; and, in the Canadian content study, how disrupting antioxidant defences in a single organ can extend longevity. https://youtu.be/uiEcPFH0EDk
Kicking off the new year with a lifespan special, we will take a look at reversing the senescence of senescent cells to increase mouse lifespan; the discovery and beneficial effects of a subset of youthful stem cells which can also increase mouse longevity; the most comprehensive study of life-extending molecules in the roundworm c.elegans ; and in the Canadian Content study, how disrupting the antioxidant defences in a specific organ in c.elegans can increase its lifespan.
Individual and additive effects of vitamin D, omega-3 and exercise on DNA methylation clocks of biological aging in older adults from the DO-HEALTH trial
Longevity Snapshot #5 — Reviewing a trial which shows that a combination of Omega 3, Vitamin D and Exercise slows down biological aging in older adults according to 4 epigenetic clocks.
Applying epigenetic clocks to samples from the DO-HEALTH trial, Bischoff-Ferrari et al. report a small protective effect of omega-3 supplementation over 3 years on several clocks and an additive protective effect of omega-3, vitamin D and exercise using PhenoAge.
Inside the scientific quest to reverse human aging
Superlongevity via epigenetic reprogramming. 🏆
Life Biosciences:
“If the FDA approves its application, the company will repeat the methods from the mouse and monkey experiments, Rosenzweig-Lipson said. Scientists will inject volunteers’ eyes with Yamanaka factors that can be turned off or on with the antibiotic doxycycline, Rosenzweig-Lipson said. The hope is that the cells in people’s damaged optic nerves will grow more youthful at an epigenetic level, and their vision will improve.”
Can reprogramming our genes make us young again? A breakthrough in longevity research may be nearing its first human trials.
Scientists Discover Key Protein That May Reverse Aging at the Cellular Level
Researchers from Osaka University have discovered that the protein subunit AP2A1 may play a role in the unique structural organization of senescent cells.
There are countless products on the market that claim to restore a youthful appearance by reducing wrinkles or tightening the jawline. But what if aging could be reversed at the cellular level? Researchers in Japan may have uncovered a way to do just that.
A recent study published in Cellular Signaling by scientists at Osaka University identifies a key protein that regulates the transition between “young” and “old” cell states.
The secret of how Greenland sharks can live for centuries without getting cancer
The eye protein rhodopsin of the Greenland shark was found to have amino acid variations that made them more adept at processing blue-light wavelengths – a feature that is advantageous when living in the dim deep ocean waters.
“These genomic analyses offer new insights into the molecular basis of the exceptional longevity of the Greenland shark and highlight potential genetic mechanisms that could inform future research into longevity,” scientists wrote in the study.
