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As long as they don’t enter the food supply.


First micropigs, now dogs: Scientists in China have used a gene-editing technique to produce the world’s first genetically engineered pooches. Although these two endeavors share scientific roots, with their production aimed at assisting medical research, unlike the teeny tiny pigs, the researchers behind this latest project are not intending to sell their customized animals as pets.

So it probably won’t come as a surprise that the dogs weren’t engineered to be cuter, fluffier or more pocket-sized: they had their DNA tweaked to make them more muscly. The first of many potential edits the team would like to carry out, this was done with the forces in mind.

With greater muscle mass, the dogs “are expected to have a stronger running ability, which is good for hunting, police (military) applications,” researcher Liangxue Lai from the Guangzhou Institutes of Biomedicine and Health told MIT Technology Review. Later on down the line, the scientists would like to manipulate the dog genome in order to mimic human diseases, which could better our understanding and treatment of certain conditions.

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To whom it may concern,

Cryonics is a legitimate science-based endeavor that seeks to preserve human beings, especially the human brain, by the best technology available. Future technologies for resuscitation can be envisioned that involve molecular repair by nanomedicine, highly advanced computation, detailed control of cell growth, and tissue regeneration.

With a view toward these developments, there is a credible possibility that cryonics performed under the best conditions achievable today can preserve sufficient neurological information to permit eventual restoration of a person to full health.

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This short video (with some fun integrated graphics) is from an interview I did with El Pais (the largest newspaper in Spain). It highlights some of the emerging technologies and approaches which have the potential to shift health, medicine and biopharma from its intermittent and reactive physician-centric mode, to an era of more continuous data and a proactive approach, in which the individual is increasingly empowered and integrated into personalized wellness, diagnosis and therapy. The video is below and some associated thoughts follow:

Diagnostics- Era of the digital black bag: Ranging from an eye, ear and throat exam (from connected devices designed for the patient like CellScope, MedWand and Tyto) to cardiac exams enabled by low cost EKG’s (AliveCor and Kito), digital diagnostics is coming to the home. Some will even do automated interpretations (i.e. the EKG interpreted by the app and send to the cloud), where the diagnosis and management of disease will increasingly be enabled outside of the usual clinic, ER or hospital. Wearable patches that integrate multiple vital signs, such as those developed by Vital Connect and Proteus Digital Health will enable more complex disease management and monitoring with ICU level data (EKG, respiratory rate, temperature, position and more), outside of the clinical environment.

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“The world is facing some huge problems. There’s a lot of talk about how to solve them. But talk doesn’t reduce pollution, or grow food, or heal the sick. That takes doing. This film is the story about a group of doers, the elegantly simple inventions they have made to change the lives of billions of people, and the unconventional billionaire spearheading the project.”

Aging is 100% genetic, the reason you go from infant to child to adult to old age.

We need to be scrutinizing Progeria, and the case of the girl who died at 20 and was stuck at the age of a toddler, for the key to the genes that will pause aging. While nanotechnology advances parallel with the cure for all diseases.


Once a bucket of genes linked to aging is removed, the lifespan of cells increases significantly, American scientists discovered during ten years of meticulous research, stressing that the results could be applied to humans.

An “exhaustive, ten-year effort” allowed scientists at the Buck Institute for Research on Aging and the University of Washington to identify some 238 genes which could be targeted to improve human health and possibly extend life spans by 60 percent. The paper was published on Thursday in the journal Cell Metabolism.

‘Yoga for people of color’ is racist – conservative radio host http://t.co/FFT0agBL7Opic.twitter.com/oaOA4H0ALn — RT (@RT_com) October 11, 2015

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Liz Parrish is the Founder and CEO of BioViva Sciences USA Inc. BioViva is committed to extending healthy lifespans using gene therapy. Liz is known as “the woman who wants to genetically engineer you,” she is a humanitarian, entrepreneur and innovator and a leading voice for genetic cures. As a strong proponent of progress and education for the advancement of gene therapy, she serves as a motivational speaker to the public at large for the life sciences. She is actively involved in international educational media outreach and sits on the board of the International Longevity Alliance (ILA). She is an affiliated member of the Complex Biological Systems Alliance (CBSA) whose mission is to further scientific understanding of biological complexity and the nature and origins of human disease. She is the founder of BioTrove Investments LLC and the BioTrove Podcasts which is committed to offering a meaningful way for people to learn about and fund research in regenerative medicine. She is also the Secretary of the American Longevity Alliance (ALA) a 501©(3) nonprofit trade association that brings together individuals, companies, and organizations who work in advancing the emerging field of cellular & regenerative medicine with the aim to get governments to consider aging a disease. I am not a medical doctor or scientist. I can not answer details of therapy. I would like to discuss my experience of creating BioViva, organizing the gene therapies, and then finally being able to administer it to the first human.

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BOSTON, Sept. 29, 2015 /PRNewswire/ — Veritas Genetics today announced that the company is making it possible for participants in the Personal Genome Project (PGP) to be among the first to get their whole genome sequenced and interpreted for less than a $1,000.

Led by Veritas Genetics Co-Founder Dr. George Church, Professor of Genetics at Harvard Medical School and Director of the Personal Genome Project, PGP is a long-term effort to sequence thousands of complete genomes to enable research into personal genomics and personalized medicine. PGP has more than 16,000 participants worldwide.

The “$1,000 Genome” has long been considered the tipping point when sequencing and interpreting the human genome becomes commonplace and begins to rapidly increase what is known and to dramatically impact healthcare. The catchphrase underscores how far science has come since the actual cost of the Human Genome Project, estimated at $2.7 billion spent over a decade.

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This short video (with some fun integrated graphics) is from an interview I did with El País (the largest newspaper in Spain). It highlights some of the emerging technologies and approaches which have the potential to shift health, medicine and biopharma from an intermittent and reactive physician-centric mode, to an era of more continuous data and a proactive approach in which the individual is increasingly empowered and integrated into personalized wellness, diagnosis and therapy.

Read more

Encapsulation Pictures

Fear of scientists “playing god” is at the centre of many a plot line in science fiction stories. Perhaps the latest popular iteration of the story we all love is Jurassic World (2015), a film I find interesting only for the tribute it paid to the original Michael Crichton novel and movie Jurassic Park.

Full op-ed from h+ Magazine on 7 October 2015 http://hplusmagazine.com/2015/10/07/opinion-synthetic-biolog…f-mankind/

john hammond jurrasic parkIn Jurassic Park, a novel devoted to the scare of genetic engineering when biotech was new in the 1990s, the character of John Hammond says:

“Would you make products to help mankind, to fight illness and disease? Dear me, no. That’s a terrible idea. A very poor use of new technology. Personally, I would never help mankind.”

What the character is referring to is the lack of profit in actually curing diseases and solving human needs, and the controversy courted just by trying to get involved in such development. The goal to eradicate poverty or close the wealth gap between rich and poor nations offers no incentive for a commercial company.

Instead, businesses occupy themselves with creating entertainment, glamour products and perfume, new pets, and other superfluities that biotech can inevitably offer. This way, the companies escape not only moral chastisement for failing to share their technology adequately or make it freely available, but they can also attach whatever price tag they want without fear of controversy.

It is difficult for a well-meaning scientist or engineer to push society towards greater freedom and equality in a single country. It is even harder for such a professional to effect a great change over the whole world or improve the human condition the way transhumanists, for example, have intended.

Although discovery and invention continue to stun us all on an almost daily basis, such things do not happen as quickly or in as utilitarian a way as they should. And this lack of progress is deliberate. As the agenda is driven by businessmen who adhere to the times they live in, driven more by the desire for wealth and status than helping mankind, the goal of endless profit directly blocks the path to abolish scarcity, illness and death.

Today, J. Craig Venter’s great discoveries of how to sequence or synthesize entire genomes of living biological specimens in the field of synthetic biology (synthbio) represent a greater power than the hydrogen bomb. It is a power we must embrace. In my opinion, these discoveries are certainly more capable of transforming civilization and the globe for the better. In Life at the Speed of Light(2013), that is essentially Venter’s own thesis.

And contrary to science fiction films, the only threat from biotech is that humans will not adequately and quickly use it. Business leaders are far more interested in profiting from people’s desire for petty products, entertainment and glamour than curing cancer or creating unlimited resources to feed civilization. But who can blame them? It is far too risky for someone in their position to commit to philanthropy than to stay a step ahead of their competitors.

Even businessmen who later go into philanthropy do very little other than court attention in the press and polish the progressive image of the company. Of course, transitory deeds like giving food or clean water to Africans will never actually count as developing civilization and improving life on Earth, when there are far greater actions that can be taken instead.

It is conspicuous that so little has been done to develop the industrial might of poor countries, where schoolchildren must still live and study without even a roof over their heads. For all the unimaginable destruction that our governments and their corporate sponsors unleash on poor countries with bombs or sanctions when they are deemed to be threatening, we see almost no good being done with the same scientific muscle in poor countries. Philanthropists are friendly to the cause of handing out food or money to a few hungry people, but say nothing of giving the world’s poor the ability to possess their own natural resources and their own industries.

Like our bodies, our planet is no longer a sufficient vehicle for human dreams and aspirations. The biology of the planet is too inefficient to support the current growth of the human population. We face the prospect of eventually perishing as a species if we cannot repair our species’ oft-omitted disagreements with nature over issues of sustainability, congenital illness and our refusal to submit to the cruelties of natural selection from which we evolved.

Once we recognize that the current species are flawed, we will see that only by designing and introducing new species can suffering, poverty and the depletion of natural resources be stopped. Once we look at this option, we find already a perfect and ultimately moral solution to the threats of climate change, disease, overpopulation and the terrible scarcity giving rise to endless injustice and retaliatory terrorism.

The perfect solution could only be brought to the world by a heroic worker in the fields of biotech and synthetic biology. Indeed, this revolution may already be possible today, but fear is sadly holding back the one who could make it happen.

Someone who believes in changing the human animal with technology must believe in eradicating poverty, sickness and injustice with technology. For all our talk of equality and human rights in our rhetoric, the West seems determined to prevent poorer countries from possessing their own natural resources. A right guaranteed by the principles of modernization and industrialization, which appears to have been forgotten. Instead, we prefer to watch them being nursed by the richer countries’ monopolies, technology, and workers who are there cultivating, extracting, refining, or buying all their resources for them.

So, quite contrary to the promises of modernity, we have replaced the ideal of the industrialization of poor states with instead the vision of refugee camps, crude water wells, and food aid delivered by humanitarian workers to provide only temporary relief. In place of a model of development that was altruistic and morally correct, we instead glorify the image of non-Westerners as primitives who are impossible to help yet still we try.

The world’s poor have become not the focus of attention aimed at helping humanity, but props for philanthropists to make themselves look noble while doing nothing to truly help them. What we should turn to is not a return to the failed UN development agendas of the 1970s, which were flawed, but a new model entirely, and driven by people instead of governments and UN agencies.

It is high time that we act to help mankind altruistically, rather than a select few customers. The engineers and scientists of the world need to abandon the search for profit, if only for a moment. We should call on them to turn their extraordinary talent to the absolute good of abolishing poverty and scarcity. If they do not do this, we will talk about direct action to break free the scientific gifts they refused to share.

We live in courageous times. These are times of whistle-blowers, lone activists for the truth, and lone scientist-entrepreneurs who must be praised even if our profit-driven culture stifles their great works. And although we live in courageous times, we seem not yet brave enough to take real action to overcome the human disaster.

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Synthetic biology image from https://www.equipes.lps.u-psud.fr/TRESSET/research8.html

(A) Enclosure of three red-fluorescent 200-nm spheres inside a “giant” liposome labeled with DiO. A wideband ultraviolet excitation filter was used for the simultaneous observation of these two differently stained species. Images were digitally postprocessed to balance the colors and to adjust their brightness at an equal level. (B) Trajectories of the particles. They were free to move but did not pass through the membrane. © GFP entrapped by a “giant” liposome. To get rid of noncaptured proteins, the solution was filtered by dialysis in such a way that the fluorescence background level became negligible with respect to the liposome interior. (D) Fluorescence photographs of λ-DNA-loaded liposome. λ-DNA was stained with SYBR Green, while DiI (red emission) was incorporated to liposome membrane. Liposome was observed through a narrow-band blue excitation filter (suitable for SYBR Green). (E) Same as previously with a wideband green excitation filter (suitable for DiI). Because of a low fluorescence response, part D was digitally enhanced in terms of brightness and contrast. In comparison, part E was darkened to present a level similar to part D. These pictures were taken at an interval of ~1 s, just the time to switch the filters. (E) Fluorescence picture of λ-DNA-loaded liposomes. Green dots stand for λ-DNA molecules, and lipids are labeled in red. A wideband blue excitation filter was used for this bicolor imaging, and a high-sensitivity color CCD camera captured it. [Anal. Chem. 77 (2005) 2795]