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Category: health – Page 442

Scientists are one step closer to using CRISPR gene editing on humans, with a US federal advisory panel approving the use of the technique for a study led by the University of Pennsylvania.

The scientists are seeking to use the CRISPR-Cas9 technique to create genetically altered T cells – white blood cells that play an important role in our immune system – that are more effective at fighting cancer cells in patients with melanoma, multiple myeloma, and sarcoma.

“Our preliminary data suggests that we could improve the efficacy of these T cells if we use CRISPR,” lead researcher Carl June told the National Institute of Health’s (NIH) Recombinant DNA Advisory Committee (RAC) on Tuesday.

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Washington University in St. Louis and Keio University in Japan is set to test the effectiveness and safety of the compound. Starting next month, about 10 healthy people will be administered NMN to see if can improve bodily function and stave off the effects of aging. Should it work, it would become the first bona fide anti-aging intervention available on the market.

A compound called nicotinamide mono nucleotide (NMN) has been shown to slow down the aging process and extend the lifespans of mice. We’re about to find out if it does the same thing to humans.

A planned clinical trial devised by researchers from Washington University in St. Louis and Keio University in Japan is set to test the effectiveness and safety of the compound. Starting next month, about 10 healthy people will be administered NMN to see if can improve bodily function and stave off the effects of aging. Should it work, it would become the first bona fide anti-aging intervention available on the market.

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Want to fight aging; eat this new chocolate.

Cambridge UK (PRWEB UK) 19 June 2016 Lycotec Ltd., a biotech company based in Cambridge UK, http://www.lycotec.com announces that they have developed the World’s First Longevity SIRT Chocolate, which after ingestion provides a blood level of unmodified trans-Resveratrol, t-RSV, equal to its level after drinking red wine.

T-RSV is the molecule of plant polyphenol class which is typically present in red grapes, some berries, cocoa and nuts. There are a number of beneficial health effects of t-RSV from cardioprotective to antidiabetic. However, one of its intriguing properties is the ability to activate a group of SIRT genes. These genes are responsible for controlling cellular stress protection and longevity.

When t-RSV is consumed as part of food, or a beverage, or as an isolated extract in the form of most supplements, it quickly gets modified and inactivated in the digestive tract. Drinking red wine is the only known exception when t-RSV can reach the blood in an unmodified active form at a detectable level.

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Crowdfunding Campaign: https://www.lifespan.io/campaigns/the-major-mouse-testing-program/

We are testing a combination of compounds which clear out dysfunctional cells in the body, called Senolytics, to see if we can extend maximum lifespan and healthspan in mice. Please subscribe, share, and fund our Lifespan.io campaign today!

MMTP — Major Mouse Testing Program.
http://majormouse.org

Is a project by the International Longevity Alliance.
http://longevityalliance.org

Subscribe: https://www.youtube.com/user/LifespanIO

Continue reading “MMTP — Major Mouse Testing Program — Interview with David Gems” | >

WEDNESDAY, June 15, 2016 (HealthDay News) — Brain cancer patients might benefit from an implantable ultrasound device that appears to enhance chemotherapy treatment, a small study says.

Researchers from the Pitie-Salpetriere Hospital in Paris and other French institutions tested the experimental device on 15 patients with recurrent glioblastoma, a particularly deadly brain cancer. When the so-called SonoCloud was activated, sound waves opened the blood-brain barrier, letting in more chemotherapy, they said.

“The walls of the blood vessels in the brain are very difficult to cross for certain molecules,” said Frederic Sottilini, CEO of Paris-based CarThera, the company developing SonoCloud.

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Awesome!

University of Oklahoma researchers will apply a new analytical technology that could ultimately provide a powerful tool for improved treatment of cancer patients in Oklahoma and beyond. Using mass spectrometry, an analytical instrument for sensitive detection and accurate identification of molecules, the team will quantitate the amount of anti-cancer drugs present in individual cancer cells, including those in bladder cancer cells isolated from patients undergoing chemotherapy. The method will provide a means to establish ideal dosing regimens that delivers effective chemotherapeutic concentrations to patients with minimal toxicities.

Anthony Burgett and Zhibo Yang, assistant professors in the Department of Chemistry and Biochemistry in the OU College of Arts and Sciences, and affiliates of the Stephenson Cancer Center, in collaboration with Jonathan E. Heinlen, M.D., assistant professor in the Department of Urology at the OU Health Sciences Center and a Stephenson Cancer Center researcher, will fully develop the novel first-in-class mass spectrometric technology—the Single Probe—capable of performing single-cell mass spectrometry of compounds inside of living single cancer cells as a bioanalytical method to improve efficacy and toxicities of chemotherapy in patients.

“One clear lesson from scientific progress is that new technologies often lead to major advances. This new single cancer cell mass spectrometry analysis could propel us forward to a new frontier in biological analysis, and we are excited to see where this technology, with its possible scientific and biomedical applications, could lead,” said Burgett.

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After axonal injury, nearby mitochondria become incapable of producing ATP, as indicated by their change in color from yellow (healthy) to green (damaged) (credit: Zhou et al., 2016)

Boosting the transport of mitochondria (cell energy suppliers) along neuronal axons enhances the ability of mouse nerve cells to repair themselves and regrow after injury or disease, researchers at the National Institute of Neurological Disorders and Stroke report in The Journal of Cell Biology.

Neurons need large amounts of energy to extend their axons long distances through the body. This energy — in the form of adenosine triphosphate (ATP) — is provided by mitochondria.

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Agree. So as a tech engineer, futurist, innovator, leader you have 3 key tracks to remain relevant in the future: bio/ living technology, quantum, and a hybrid of living/ bio meets quantum computing.

Editor €™s Note: Richard van Hooijdonk is a futurist and international keynote speaker on future technologies and disruption and how these technologies change our everyday lives. Van Hooijdonk and his international team research €˜mega trends €™ on digital health, robotic surgery, drones, the internet-of-things, 3D/4D printing, Big Data and other how new technologies affects many industries.

With people living increasingly longer lives, medical care from surgeons, physicians, pharmacists and dentists will increase as well. And since the future of healthcare will look very different from what it is today, the medical field may just be the right industry for you, even if being a doctor or nurse is not your calling. Many new technologies will be incorporated into the healthcare industry and we will see things like robotic surgeries and 3D-printed organ implants, to name a few. This means we will be seeing a whole new host of career opportunities, even for jobs that don €™t actually exist yet.

1. Healthcare Navigator €“ Guides patients through the complex medical system of the future

Being sick can be extremely stressful €“ to yourself, the doctors and nursing staff. But your family and loved ones also have a lot to deal with when you are ill. Technology will make healthcare more and more complex to navigate in the future. We €™ll be introduced to bio-printers, electronic pills, 3D-printed medication, surgical robots and DNA manipulation. To make sense of all these new technologies and treatments, and guide the patient as well as family members, healthcare navigators will become indispensible.

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Now this is going to be very interesting. We will learn a lot about self control, stress, and how cultural condition definitely applies to how people handles different forms and types of stress. Cannot wait to see the results of this study. And, with the government taking these first steps may actually show hope.

China’s mental health record is tarred by social stigma and a lack of resources. While public initiatives are now seeking to rectify the issue, the country’s active startup ecosystem is also competing to fill the gaps.

According to a study published in 2011, a staggering 91.8 per cent of Chinese people with a mental health diagnosis never seek help. Part of that has to do with the shortage of trained mental health professionals in China, as well as the country’s psychiatrist-to-patient ratio, which is as low as 1.24 per 100,000 patients, compared to the global average of 4.15 per 100,000.

“The problem is huge,” says Jin Hsueh, the co-founder and CEO of KaJin Health, a Taiwanese startup that provides an online counseling service to people in Chinese-speaking communities. “There are [90] million [people with] depression in China, and very, very [few] that ever seek for help, talking to a doctor or therapist.”

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