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A team of researchers led by professor Jean-Christophe Marine (VIB-KU Leuven) has identified NEAT1, a non-coding RNA, as a potential therapeutic target in the fight against cancer. In collaboration with the Cédric Blanpain lab (ULB), VIB researchers have shown that NEAT1 plays an important role in the survival of highly dividing cells — and in particular of cancer cells. These findings can help develop new drugs that target NEAT1, in order to kill cancer cells more effectively.

As a non-coding RNA, NEAT1 is not translated into a protein. It does however contribute to the formation of so-called ‘paraspeckles’, subnuclear particles that can be found in the cell nuclei of cancer cells. The function of these particles has remained obscure. Although highly conserved through evolution, NEAT1 appears to be dispensable for normal embryonic development and adult life as mice lacking NEAT1 are viable and healthy.

Guarding the genome

PhD student Carmen Adriaens (VIB-KU Leuven): “In our study, we have found that the expression of NEAT1 in the cell nucleus is regulated by p53. This protein plays an important role in protecting people against cancer and is known as ‘the guardian of the genome’. When a cell is stressed or damaged, p53 will upregulate the expression of NEAT1, which leads to the formation of paraspeckles. This has two possible outcomes: the cell can either go into transient cell cycle arrest, giving it time to deal with the stress and repair the damage before continuing cell division. If the stress or damage is too high, however, p53 will instruct the cell to commit suicide and die.”

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FRIDAY, July 1, 2016 (HealthDay News) — Electrical pulses to the brain may help restore vision in some partially blind patients, German researchers report.

Glaucoma and other types of damage to the eye’s optic nerve typically cause permanent damage. But, the new technique appears to kick-start the brain’s visual control centers, the researchers explained.

A 10-day treatment regimen — entailing upwards of nearly an hour a day of electrical pulses aimed directly into the eye — improved vision among patients who were losing their sight, the researchers said.

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Games to help fight obesity?


Innovative research uses technology to help people with a sweet-tooth lose weight. Researchers believe they can train the brain to better resist temptation and warn people of an unhealthy urge before the temptation occurs.

Specifically, Drexel University psychologists have created a computer game aimed at improving users’ inhibitory control. Additionally, the investigators are also rolling out a mobile app that used in conjunction with the Weight Watchers app, will alert users on unhealthy urges before they strike.

The game is designed to improve a person’s “inhibitory control,” the part of the brain that stops you from giving into unhealthy cravings — even when the smell of French fries is practically begging you to step inside a fast food restaurant.

One of the biggest challenges in treating brain cancer has been getting drugs to cross the blood-brain barrier and attack tumours where they’re needed.

But scientists say they’ve now developed a truly soluble liquid aspirin that can make its way into the brain, and, in the lab at least, kill cancerous glioblastoma cells without harming healthy brain tissue.

The research hasn’t been published in a peer-reviewed journal as yet, so we need to take it with a big pinch of salt for now. But scientists from the Brain Tumour Research Centre at the University of Portsmouth in the UK just presented it at the Brain Tumours 2016 conference in Poland.

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Q-Dot demand in Healthcare is predicted to be high.

http://embedded-computing.com/news/rising-quantum-dots-market/#


Quantum Dots Market is driven by increasing demand for energy efficient displays and lighting solutions, North America accounted for largest quantum dots market share, use of quantum dots in solar cells and VLSI design is expected to open new possibilities for quantum dots market.

Quantum dots are semiconducting nanoparticles that range from 1nm to 10nm diameter in size and demonstrate quantum mechanical properties. The peculiarity of quantum dots is that they have ability to unite their semiconductor properties with those of nanomaterials. In addition, tunable nanocrystal size and superior optical properties have made quantum dots attractive semiconducting material for variety of applications in the field of healthcare, optoelectronics, solar energy, and security among others.

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Its painful to bear views that make many think I’m an imbicile and dislike me. So please, if anybody has a rational argument why any of this is wrong, I beg to be enlightened. I’ve set up a diagram for the purpose that will support you to add your criticism exactly where it is pertinent. https://tssciencecollaboration.com/graphtree/Are%20Vaccines%20Safe/406/4083

(1) The National Academy’s Reviews Of Vaccine Safety
The Institute of Medicine of the National Academies has provided several multi-hundred page surveys studying the safety of vaccines, but rather than reassuring, these itemize some iatrogenic conditions being caused, and pronounce the scientific literature inadequate to say whether most others are. The 2011 Institute of Medicine (IOM) Review[1] looked at 146 vaccine-condition pairs for causality, reporting:

  • 14 for which the evidence is said to convincingly support causality, the vaccine is causing the condition.
  • 4 where the evidence is said to favor acceptance.
  • 5 where the evidence is said to favor rejection, including MMR causing autism.
  • 123 where the evidence is said insufficient to evaluate.

The 2003 IOM Review on multiple vaccines said[2]:
“The committee was unable to address the concern that repeated exposure of a susceptible child to multiple immunizations over the developmental period may also produce atypical or non-specific immune or nervous system injury that could lead to severe disability or death (Fisher, 2001). There are no epidemiological studies that address this.”
and:
“the committee concludes that the epidemiological and clinical evidence is inadequate to accept or reject a causal relationship between multiple immunization and an increased risk of allergic disease, particularly asthma.”

  • None of the IOM Safety Reviews[1][2][3][4] addressed the aluminum (for example whether the aluminum is causing autism), or mentioned contaminants, or discussed animal models although they had concluded as just quoted there is generally no epidemiological or clinical data worth preferring.

(2) The Aluminum.
Alum was added to vaccines back in the 1920’s, with no test of parenteral toxicity until recently[5], because it prods the immature immune system out of its normal operating range.[6] Maybe they figured aluminum is common in the environment, but injection bypasses half a dozen evolved sequential filters that normally keep it out of circulatory flow during development. Vaccines put hundreds of times as much aluminum into infants’ blood as they would otherwise get, and in an unnatural form that is hard for the body to remove.[7][8 (cfsec 4.2)][9]. The published empirical results indicate its highly toxic.

  • Bishop et al in NEJM 97 reported a Randomized Placebo Controlled(RPC) test on preemies.[10][11] Scaling the toxicity they measured to the 4000 mcg in the first six months projects the vaccine series’ aluminum as costing each recipient maybe 15 IQ points and bone density.[12]
  • Animal RPC experiments also show highly toxic[13][14][15][16]
  • The applicable epidemiology suggests its highly toxic.[8][18][19][20][21][22] Discussed more in point 8 below, basically every study that compares more to less finds less much better.
  • Numerous clinical publications, whole special issues, on ASIA (Autoimmune Syndrome Induced by Adjuvants)[23][24][25]
  • Any “placebo” controlled test I’ve ever found of an adjuvanted vaccine, the “placebo” contained an adjuvant.
  • Safety reviews ignore the issue. Search the pdfs. [1][2][3][4]
  • The FDA[26] cites a theory paper[27] that compares a published MRL based on dietary experiments in weaned rodents (thus completely uninformed about toxicity in early development) to a theoretical model of blood aluminum levels from the vaccines, and disdains all the above cited empirical evidence.

(3) The Safety Studies Ignore Confounding Patient Behavior
Since there are no Randomized Placebo Controlled (RPC) trials supporting vaccines, virtually all studies report on the association (or lack thereof) between vaccines and some iatrogenic condition. But parents who believe vaccines made their kids sick, stop vaccinating them, which systematically moves sick or vaccine damaged kids in the studies into the “low vaccine”, “low thimerisol”, or etc. bin. This invalidates most studies supporting safety (and the few remaining ones suck for other reasons). Numerous studies report incredible preventative effects for vaccines, presumably because of this corruption, like having more thimerisol or more MMR’s is strongly preventative of autism and other mental development issues[28][29][30], or like having more vaccines was strongly preventative of atopy, apparently even years before patients got the vaccines[31]. The fact this confounding factor is overlooked demonstrates extreme confirmation bias and is the defining factor of Cargo Cult Science according to R.P. Feynman.[32]

(4) The Animal Models
Animal models reliably and repeatably show in RPC tests (a) that vaccines at the wrong time in development damage the adult brain or behavior [33][34] and (b) that multiple vaccines cause autoimmune disease even in animals bred to be non-autoimmune[35][36]. The effects are said to be robust, and as we’ve already seen there isn’t good human data rebutting them.

(5) The Contaminants
Studies have repeatedly found contaminants such as viruses, retroviruses, circoviruses, and human DNA in vaccines seemingly whenever tested,
and I’ve found no reason to believe off the shelf vaccines are free[37][38][39][40][41]. Reported contaminants have included SV-40 in polio vaccines which were administered even though scientists knew the vaccines were contaminated and already had hunches and experiments indicating SV-40 causes cancer[41][42]. Chimpanzee Coryza Virus became known in humans as RSV and has killed many millions of infants and hospitalizes 100,000/yr in America today[43]. Contaminated polio vaccine is plausibly also the origin of HIV[44][41]. There are discovered viral contaminants in vaccines today[38][39], with unknown long term effects, as well as I expect many undiscovered contaminants.

(6) Studies Ask Whether Some One Vaccine Damages, and Thus Miss That Many Do.
Virtually every study not reporting damage compares kids who got numerous vaccines to kids who got numerous vaccines. Such studies wouldn’t show statistically significant results no matter how much damage the vaccines are doing, unless one vaccine or vector by itself is doing comparable or more damage than the rest put together. The studies more or less test the hypothesis one vaccine is invisibly damaging, the rest are fine, and the studies are all obscured in the presence of multiple problems, much less the kind of timing and interaction effects observed in animal models. The one study[45] often touted as proving “The Risk of Autism is Not Increased by ‘Too Many Vaccines Too Soon’”[46] in fact compares patients based on antigens, and since DTP had more than 3000 antigens and no other vaccine common among the study patients had more than a handful, effectively compared patients who’d had DTP and dozens of vaccines to patients who did not have DTP (many had DTaP instead) and dozens of vaccines. The only counterexamples to this I’ve found are contrived in bizarre ways to avoid reality, such as the study that withheld the 2 month vaccines till 3 months from a group of kids, and asked the mothers, who were terrified enough a bunch insisted on changing back to the early vaccination group, to record symptoms with no doctor even consulted, identifying the placebo effect as vaccine prevention of diseases. The authors wrote it would have been unethical to give a placebo at 2 months to the kids getting the vaccine at 3 months, in order to do the experiment blind, but apparently consider it ethical to inject dozens of vaccines into your kids with zero placebo controlled testing.[47] [48]

(7) The Extensive Evidence Indicating Flu Vaccines Damage Immune Systems, Particularly in Children.

Results from quantitative MRI and neuropsychological testing show unprecedented improvements in ten patients with early Alzheimer’s disease (AD) or its precursors following treatment with a programmatic and personalized therapy. Results from an approach dubbed metabolic enhancement for neurodegeneration are now available online in the journal Aging.

The study, which comes jointly from the Buck Institute for Research on Aging and the UCLA Easton Laboratories for Neurodegenerative Disease Research, is the first to objectively show that memory loss in patients can be reversed, and improvement sustained, using a complex, 36-point therapeutic personalized program that involves comprehensive changes in diet, brain stimulation, exercise, optimization of sleep, specific pharmaceuticals and vitamins, and multiple additional steps that affect brain chemistry.

“All of these patients had either well-defined mild cognitive impairment (MCI), subjective cognitive impairment (SCI) or had been diagnosed with AD before beginning the program,” said author Dale Bredesen, MD, a professor at the Buck Institute and professor at the Easton Laboratories for Neurodegenerative Disease Research at UCLA, who noted that patients who had had to discontinue work were able to return to work and those struggling at their jobs were able to improve their performance. “Follow up testing showed some of the patients going from abnormal to normal.”

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It would seem that no one’s immune from the effects imposed by our increasingly sophisticated artificial intelligence and robotics — not even doctors. As research from Indiana University has revealed, a new computer program is doing a better job than doctors when it comes to both diagnosing and treating health conditions — and by a significant margin.

The system, which uses decision making processes similar to the Jeopardy-bot, Watson, was recently given the task of analyzing and predicting the health outcomes of 500 real individuals. After plugging in the relevant data — which mostly had to do with clinical depression and chronic diseases like high blood pressure and diabetes — researchers Kris Hauser and Casey Bennett compared the outcomes to the simulated treatment prescriptions.

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