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Category: health – Page 389

A systematic study of microdosing psychedelics

The phenomenon of ‘microdosing’, that is, regular ingestion of very small quantities of psychedelic substances, has seen a rapid explosion of popularity in recent years. Individuals who microdose report minimal acute effects from these substances yet claim a range of long-term general health and wellbeing benefits. There have been no published empirical studies of microdosing and the current legal and bureaucratic climate makes direct empirical investigation of the effects of psychedelics difficult. In Study One we conducted a systematic, observational investigation of individuals who microdose. We tracked the experiences of 98 microdosing participants, who provided daily ratings of psychological functioning over a six week period. 63 of these additionally completed a battery of psychometric measures tapping mood, attention, wellbeing, mystical experiences, personality, creativity, and sense of agency, at baseline and at completion of the study. Analyses of daily ratings revealed a general increase in reported psychological functioning across all measures on dosing days but limited evidence of residual effects on following days. Analyses of pre and post study measures revealed reductions in reported levels of depression and stress; lower levels of distractibility; increased absorption; and increased neuroticism. To better understand these findings, in Study Two we investigated pre-existing beliefs and expectations about the effects of microdosing in a sample of 263 naïve and experienced microdosers, so as to gauge expectancy bias. All participants believed that microdosing would have large and wide-ranging benefits in contrast to the limited outcomes reported by actual microdosers. Notably, the effects believed most likely to change were unrelated to the observed pattern of reported outcomes. The current results suggest that dose controlled empirical research on the impacts of microdosing on mental health and attentional capabilities are needed.

Citation: Polito V, Stevenson RJ (2019) A systematic study of microdosing psychedelics. PLoS ONE 14: e0211023. https://doi.org/10.1371/journal.pone.

Editor: Danilo Arnone, King’s College London, UNITED KINGDOM

Rwanda Has Just Completed Over 10,000 Deliveries of Health Supplies Via Medical Drones

Rwanda’s advancements on the technological front have been dazzling, with that enviable touch of innovation. Ever since deliveries of health supplies through drones commenced in 2016, the stats have been phenomenal.

To date, over 10,000 health supply deliveries have been completed and this is such a huge feat. Medical drones were launched in October 2016, in partnership with #Zipline Inc. Rwanda is the first country on the continent, and in the world to have such services in the health sector. Such monumental success easily makes Rwanda’s healthcare system among the best in Africa.

Rwanda has completed over 10,000 deliveries of health supplies by medical drones.

Poll: Two Thirds of Americans Support Human Gene Editing to Cure Disease

Questions about using technologies like CRISPR to gene edit human embryos gained immediacy last month, when Chinese scientists claimed to have edited the genes of two babies in order to protect them against HIV — a move that prompted an international outcry, but also questions about when the technology will be ready for human testing.

“People appear to realize there’s a major question of how we should oversee and monitor use of this technology if and when it becomes available,” Columbia University bioethicist Robert Klitzman told the AP of the new research. “What is safe enough? And who will determine that? The government? Or clinicians who say, ‘Look, we did it in Country X a few times and it seems to be effective.

READ MORE: Poll: Edit baby genes for health, not smarts [Associated Press].

Boosting Cellular Housekeeping with Exercise and Fasting

In order to remain healthy and functional, cells have a number of maintenance systems that help them to dispose of metabolic waste and unwanted proteins. Autophagy is perhaps the best-known example of how cells purge their waste, and another is the ubiquitin-proteasome system (UPS). Researchers are working on ways to boost the activity of the UPS to improve cellular health.

The ubiquitin-proteasome system

During normal cellular function, proteins being constructed in the cell can sometimes become misfolded and start to accumulate over time, which can cause the cell to become dysfunctional and encourage diseases such as Alzheimer’s to develop as the system gums up with bent and broken proteins.

Professor JohnJoe McFadden Quantum Biology — IdeaXme — Ira Pastor


Solar Powered E-Skin for Prosthetic Limbs

Recently University of Glasgow developed a Graphene based E-Skin for prosthetic limbs. The research started with making a prosthetic arm that could sense even the minutest of pressure for gripping soft objects. It eventually yielded a prosthetic limb that was also self powering.

This was because of the development of Graphene based supercapacitors.

Graphene is now being explored for wearable electronics and health pathes because of its flexibility and ability to pick the smallest of signals.

New ‘interspecies communication’ strategy between gut bacteria and mammalian hosts uncovered

A study published today in Cell describes a form of “interspecies communication” in which bacteria secrete a specific molecule — nitric oxide — that allows them to communicate with and control their hosts’ DNA, and suggests that the conversation between the two may broadly influence human health.

The researchers out of Case Western Reserve University School of Medicine, University Hospitals Cleveland Medical Center, and Harvard Medical School tracked nitric oxide secreted by gut bacteria inside tiny worms (C. elegans, a common mammalian laboratory model). Nitric oxide secreted by gut bacteria attached to thousands of host proteins, completely changing a worm’s ability to regulate its own gene expression.

The study is the first to show gut bacteria can tap into nitric oxide networks ubiquitous in mammals, including humans. Nitric oxide attaches to human proteins in a carefully regulated manner — a process known as S-nitrosylation — and disruptions are broadly implicated in diseases such as Alzheimer’s, Parkinson’s, asthma, diabetes, heart disease, and cancer.

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