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Another E5 update. At the moment there is a great difference between the control and treated rats. The treated rats are nearing their expected lifespan. And it looks like E5 human trials are trying to be set up.


In this video we report on the Feb 2022 update from Dr. Katcher’s experiment with E5, where he is testing to see how long the rats will stay alive if they are given an E5 injection every 90 days.

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Links for this video.
Sign up for the newsletter from NTZ Publishing here:
https://www.ntzplural.com/newsletter.
Reversing age: dual species measurement of epigenetic age with a single clock.
https://www.biorxiv.org/content/10.1101/2020.05.07.082917v1.full.

Our discussion of original paper.
https://youtu.be/DokfEzQt_wk.
Playlist for Dr. Katcher August 2021 Interview Series.


Playlist 1 for Dr. Katcher.
https://www.youtube.com/playlist?list=PLkfzM7KJv6vaIQZ_n3WS6FHTpBtfS2lzw.

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The machine-learning model could help scientists speed the development of new medicines.

This technique could help scientists better understand some biological processes that involve protein interactions, like DNA replication and repair; it could also speed up the process of developing new medicines.

“Deep learning is very good at capturing interactions between different proteins that are otherwise difficult for chemists or biologists to write experimentally. Some of these interactions are very complicated, and people haven’t found good ways to express them. This deep-learning model can learn these types of interactions from data,” says Octavian-Eugen Ganea, a postdoc in the MIT Computer Science and Artificial Intelligence Laboratory (CSAIL) and co-lead author of the paper.

Ganea’s co-lead author is Xinyuan Huang, a graduate student at ETH Zurich. MIT co-authors include Regina Barzilay, the School of Engineering Distinguished Professor for AI and Health in CSAIL, and Tommi Jaakkola, the Thomas Siebel Professor of Electrical Engineering in CSAIL and a member of the Institute for Data, Systems, and Society. The research will be presented at the International Conference on Learning Representations.

Machine-learning model could help scientists speed the development of new medicines.

What are biomarkers? They are medical signals that can measure health in an accurate and reproducible way. Common examples include blood pressure readings, heart rate, and even genetic test results.

Modern digital devices measure several health parameters. Fitbit trackers use sensors such as accelerometers to tell how many steps we’ve taken in a day or how fast we’ve been walking. When can such novel health measures function as medical biomarkers?

The measures must be objective, quantifiable, and reproducible. Additionally, scientific evidence needs to show that the health attribute measured by the device maps consistently and accurately to a clinical outcome. For example, voice signals from a smartphone’s microphone can detect mild cognitive impairment due to Alzheimer’s disease. World War II, commanders and troops communicated using hand-sent Morse codes. To avoid capture by enemies, telegraph operators had to remain anonymous. Any clues about operator identity or location could influence battle outcomes.

𝙎𝙡𝙚𝙚𝙥 𝙢𝙖𝙮 𝙗𝙚 𝙤𝙣𝙚 𝙤𝙛 𝙩𝙝𝙚 𝙢𝙤𝙨𝙩 𝙥𝙤𝙩𝙚𝙣𝙩 𝙢𝙚𝙙𝙞𝙘𝙞𝙣𝙚𝙨 𝙛𝙤𝙧 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣, 𝙨𝙘𝙞𝙚𝙣𝙩𝙞𝙨𝙩𝙨 𝙖𝙧𝙚 𝙙𝙞𝙨𝙘𝙤𝙫𝙚𝙧𝙞𝙣𝙜, 𝙖𝙨 𝙩𝙝𝙚𝙮 𝙚𝙭𝙥𝙡𝙤𝙧𝙚 𝙩𝙝𝙚 𝙞𝙣𝙣𝙚𝙧 𝙡𝙖𝙗𝙮𝙧𝙞𝙣𝙩𝙝𝙨 𝙤𝙛 𝙩𝙝𝙚 𝙩𝙝𝙧𝙚𝙚-𝙥𝙤𝙪𝙣𝙙 𝙤𝙧𝙜𝙖𝙣 𝙙𝙪𝙧𝙞𝙣𝙜 𝙙𝙚𝙚𝙥 𝙨𝙡𝙚𝙚𝙥 𝙖𝙣𝙙 𝙙𝙧𝙚𝙖𝙢 𝙘𝙮𝙘𝙡𝙚𝙨 𝙞𝙣 𝙗𝙤𝙩𝙝 𝙝𝙚𝙖𝙡𝙩𝙝 𝙖𝙣𝙙 𝙙𝙞𝙨𝙚𝙖𝙨𝙚.

The Neuro-Network.

𝐂𝐚𝐧 𝐝𝐞𝐞𝐩 𝐬𝐥𝐞𝐞𝐩 𝐡𝐞𝐥𝐩 𝐝𝐞𝐯𝐚𝐬𝐭𝐚𝐭𝐢𝐧𝐠 𝐛𝐫𝐚𝐢𝐧 𝐝𝐢𝐬𝐨𝐫𝐝𝐞𝐫𝐬? 𝐒𝐜𝐢𝐞𝐧𝐭𝐢𝐬𝐭𝐬 𝐬𝐭𝐮𝐝𝐲𝐢𝐧𝐠 𝐏𝐚𝐫𝐤𝐢𝐧𝐬𝐨𝐧’𝐬 𝐰𝐚𝐧𝐭 𝐭𝐨 𝐟𝐢𝐧𝐝 𝐨𝐮𝐭

𝙈𝙚𝙙𝙞𝙘𝙖𝙓𝙥𝙧𝙚𝙨𝙨:


Sleep may be one of the most potent medicines for the brain, scientists are discovering, as they explore the inner labyrinths of the three-pound organ during deep sleep and dream cycles in both health and disease.

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Other Frequent contributors include Michio Kaku & Neil DeGrasse Tyson.

Michio Kaku Playlist: https://bigth.ink/kaku.
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Join Big Think Edge, to gain access to a world-class learning platform focused on building the soft skills essential to 21st century success. It features insight from many of the most celebrated and intelligent individuals in the world today. Topics on the platform are focused on: emotional intelligence, digital fluency, health and wellness, critical thinking, creativity, communication, career development, lifelong learning, management, problem solving & self-motivation.

Safed’s Ziv Medical Center has sent a letter to Health Ministry director Nachman Ash requesting he grant emergency authorization for the anti-COVID drug Amor 18 developed by the Israeli company Amorphical in order to treat patients in moderate to serious condition due to the coronavirus, Channel 2 reported Friday.

In letter to Health Ministry director, Ziv Medical Center points to promising results from Amor 18’s clinical trial, where all patients who received drug went on to recover (drug uses Amorphous Calcium Carbonate: ACC).

Israeli biotech company Amorphical recently published what it says are promising results from the second stage of its Amor 18 clinical study.

-please note: Regeneron helped end the ebola pandemic by ending clinical trials early and getting treatments to patients ASAP.

Clinical trial: https://clinicaltrials.gov/ct2/show/NCT04900337

Innovating Life-Saving Therapeutic Devices — Dr. Amy Throckmorton, PhD — BioCirc Research Laboratory, Drexel University School of Biomedical Engineering, Science and Health Systems.


Dr. Amy Throckmorton, Ph.D. (https://drexel.edu/biomed/faculty/core/ThrockmortonAmy/) is Associate Professor and Director of the BioCirc Research Laboratory, in the School of Biomedical Engineering, Science and Health Systems, at Drexel University.

The BioCirc Research Laboratory seeks to improve the treatment strategies and therapeutic options for pediatric and adult patients suffering from acquired or congenital heart disease by developing unique features for inclusion in the design of blood pumps and to develop entirely new designs of blood pumps for patients with single ventricle or biventricular circulations as a bridge-to-transplant, bridge-to-recovery, or destination therapy.

Prior to this position, in the Department of Mechanical and Nuclear Engineering at the Virginia Commonwealth University, Dr. Throckmorton served as Associate Professor and previously held the chaired Qimonda Assistant Professorship.

Dr. Throckmorton received her PhD and MS in Biomedical Engineering, as well as a BS in Chemical Engineering, from the University of Virginia.

𝙍𝙚𝙨𝙚𝙖𝙧𝙘𝙝𝙚𝙧𝙨 𝙛𝙧𝙤𝙢 𝙏𝙝𝙚 𝙐𝙣𝙞𝙫𝙚𝙧𝙨𝙞𝙩𝙮 𝙤𝙛 𝙏𝙚𝙭𝙖𝙨 𝙖𝙩 𝘿𝙖𝙡𝙡𝙖𝙨 𝙖𝙣𝙙 𝙩𝙝𝙚𝙞𝙧 𝙘𝙤𝙡𝙡𝙚𝙖𝙜𝙪𝙚𝙨 𝙝𝙖𝙫𝙚 𝙙𝙞𝙨𝙘𝙤𝙫𝙚𝙧𝙚𝙙 𝙩𝙝𝙖𝙩 𝙗𝙧𝙚𝙖𝙩𝙝𝙞𝙣𝙜 𝙧𝙖𝙩𝙚𝙨 𝙬𝙝𝙞𝙡𝙚 𝙨𝙡𝙚𝙚𝙥𝙞𝙣𝙜 𝙘𝙖𝙣 𝙗𝙚 𝙪𝙨𝙚𝙙 𝙩𝙤 𝙙𝙞𝙨𝙩𝙞𝙣𝙜𝙪𝙞𝙨𝙝 𝙘𝙤𝙜𝙣𝙞𝙩𝙞𝙫𝙚𝙡𝙮 𝙣𝙤𝙧𝙢𝙖𝙡 𝙥𝙚𝙤𝙥𝙡𝙚 𝙛𝙧𝙤𝙢 𝙩𝙝𝙤𝙨𝙚 𝙬𝙝𝙤 𝙝𝙖𝙫𝙚 𝙢𝙞𝙡𝙙 𝙘𝙤𝙜𝙣𝙞𝙩𝙞𝙫𝙚 𝙞𝙢𝙥𝙖𝙞𝙧𝙢𝙚𝙣𝙩 𝙤𝙧 𝘼𝙡𝙯𝙝𝙚𝙞𝙢𝙚𝙧’𝙨 𝙙𝙞𝙨𝙚𝙖𝙨𝙚.

The Neuro-Network.

𝐔𝐧𝐢𝐯𝐞𝐫𝐬𝐢𝐭𝐲 𝐨𝐟 𝐓𝐞𝐱𝐚𝐬 𝐚𝐭 𝐃𝐚𝐥𝐥𝐚𝐬:

𝐒𝐭𝐮𝐝𝐲: 𝐑𝐞𝐝𝐮𝐜𝐢𝐧𝐠 𝐒𝐧𝐨𝐫𝐢𝐧𝐠 𝐌𝐚𝐲 𝐇𝐞𝐥𝐩 𝐏𝐮𝐭 𝐁𝐫𝐚𝐢𝐧 𝐇𝐞𝐚𝐥𝐭𝐡 𝐑𝐢𝐬𝐤𝐬 𝐭𝐨 𝐑𝐞𝐬𝐭


Snoring not only can cause a restless night for bedfellows, but it can also disturb the processes that affect brain health. Researchers found that reducing snoring may improve cognitive function in individuals with mild impairment.

Researchers from The University of Texas at Dallas and their colleagues have discovered that breathing rates while sleeping can be used to distinguish cognitively normal people from those who have mild cognitive impairment or Alzheimer’s disease.

For the past decade, AI has been quietly seeping into daily life, from facial recognition to digital assistants like Siri or Alexa. These largely unregulated uses of AI are highly lucrative for those who control them but are already causing real-world harms to those who are subjected to them: false arrests; health care discrimination; and a rise in pervasive surveillance that, in the case of policing, can disproportionately affect Black people and disadvantaged socioeconomic groups.

Gebru is a leading figure in a constellation of scholars, activists, regulators, and technologists collaborating to reshape ideas about what AI is and what it should be. Some of her fellow travelers remain in Big Tech, mobilizing those insights to push companies toward AI that is more ethical. Others, making policy on both sides of the Atlantic, are preparing new rules to set clearer limits on the companies benefiting most from automated abuses of power. Gebru herself is seeking to push the AI world beyond the binary of asking whether systems are biased and to instead focus on power: who’s building AI, who benefits from it, and who gets to decide what its future looks like.

Full Story:


The day after our Zoom call, on the anniversary of her departure from Google, Gebru launched the Distributed AI Research (DAIR) Institute, an independent research group she hopes will grapple with how to make AI work for everyone. “We need to let people who are harmed by technology imagine the future that they want,” she says.

When Gebru was a teenager, war broke out between Ethiopia, where she had lived all her life, and Eritrea, where both of her parents were born. It became unsafe for her to remain in Addis Ababa, the Ethiopian capital. After a “miserable” experience with the U.S. asylum system, Gebru finally made it to Massachusetts as a refugee. Immediately, she began experiencing racism in the American school system, where even as a high-achieving teenager she says some teachers discriminated against her, trying to prevent her taking certain AP classes. Years later, it was a pivotal experience with the police that put her on the path toward ethical technology. She recalls calling the cops after her friend, a Black woman, was assaulted in a bar. When they arrived, the police handcuffed Gebru’s friend and later put her in a cell. The assault was never filed, she says. “It was a blatant example of systemic racism.”